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  • 11
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    Online Resource
    Fast‐Response Fluorogenic Probe for Visualizing Hypochlorite in Living Cells and in Zebrafish
    Wiley ; 2019
    In:  ChemBioChem Vol. 20, No. 6 ( 2019-03-15), p. 831-837
    Details
    In: ChemBioChem, Wiley, Vol. 20, No. 6 ( 2019-03-15), p. 831-837
    Abstract: A fast‐response fluorogenic probe—compound D1 —for monitoring hypochlorite (ClO − ), based on specific ClO − cleavage of a C=N bond and producing results observable to the naked eye, has been developed. The response of the probe to ClO − increases linearly, and the fluorescence intensity was heightened by a factor of about 25. D1 responses to ClO − , with high selectivity and sensitivity, were observable by naked eye within 10 s. D1 can not only detect levels of hypochlorite in vitro, such as in urine, but is also capable of monitoring hypochlorite content under extremely cold conditions, as low as −78 °C. Meanwhile, its good biocompatibility permitted the use of D1 to detect intracellular ClO − by confocal microscopy. Moreover, D1 was successfully applied to monitor exogenous and endogenous ClO − in zebrafish through fluorescence imaging.
    Type of Medium: Online Resource
    ISSN: 1439-4227 , 1439-7633
    URL: Issue
    URL: Article
    DOI: 10.1002/cbic.v20.6
    DOI: 10.1002/cbic.201800659
    RVK:
    VA 2918
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2020469-3
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  • 12
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    Neural Architecture Search with In‐Memory Multiply–Accumulate and In‐Memory Rank Based on Coating Layer Optimized C‐Doped Ge 2 Sb 2 Te 5 Phase Change Memory
    Wiley ; 2023
    In:  Advanced Functional Materials
    Details
    In: Advanced Functional Materials, Wiley
    Abstract: Neural architecture search (NAS), as a subfield of automated machine learning, can design neural network models with better performance than manual design. However, the energy and time consumptions of conventional software‐based NAS are huge, hindering its development and applications. Herein, 4 Mb phase change memory (PCM) chips are first fabricated that enable two key in‐memory computing operations—in‐memory multiply‐accumulate (MAC) and in‐memory rank for efficient NAS. The impacts of the coating layer material are systematically analyzed for the blade‐type heating electrode on the device uniformity and in turn NAS performance. The random weights in the searched network architecture can be fine‐tuned in the last stage. With 512 × 512 arrays based on 40 nm CMOS process, the PCM‐based NAS has achieved 25–53× smaller model size and better performance than manually designed networks and improved the energy and time efficiency by 4779× and 123×, respectively, compared with NAS running on graphic processing unit (GPU). This work can expand the hardware accelerated in‐memory operators, and significantly extend the applications of in‐memory computing enabled by nonvolatile memory in advanced machine learning tasks.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Article
    DOI: 10.1002/adfm.202300458
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 13
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    Sulfone‐Modified Covalent Organic Frameworks Enabling Efficient Photocatalytic Hydrogen Peroxide Generation via One‐Step Two‐Electron O 2 Reduction
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 26 ( 2023-06-26)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 26 ( 2023-06-26)
    Abstract: Photocatalytic oxygen reduction reaction (ORR) offers a promising hydrogen peroxide (H 2 O 2 ) synthetic strategy, especially the one‐step two‐electron (2e − ) ORR route holds great potential in achieving highly efficient and selectivity. However, efficient one‐step 2e − ORR is rarely harvested and the underlying mechanism for regulating the ORR pathways remains greatly obscure. Here, by loading sulfone units into covalent organic frameworks (FS‐COFs), we present an efficient photocatalyst for H 2 O 2 generation via one‐step 2e − ORR from pure water and air. Under visible light irradiation, FS‐COFs exert a superb H 2 O 2 yield of 3904.2 μmol h −1  g −1 , outperforming most reported metal‐free catalysts under similar conditions. Experimental and theoretical investigation reveals that the sulfone units accelerate the separation of photoinduced electron‐hole (e − ‐h + ) pairs, enhance the protonation of COFs, and promote O 2 adsorption in the Yeager‐type, which jointly alters the reaction process from two‐step 2e − ORR to the one‐step one, thereby achieving efficient H 2 O 2 generation with high selectivity.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.26
    DOI: 10.1002/anie.202305355
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 14
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    Lactate‐fueled oxidative metabolism drives DNA methyltransferase 1‐mediated transcriptional co‐activator with PDZ binding domain protein activation
    Wiley ; 2020
    In:  Cancer Science Vol. 111, No. 1 ( 2020-01), p. 186-199
    Details
    In: Cancer Science, Wiley, Vol. 111, No. 1 ( 2020-01), p. 186-199
    Abstract: Activity of transcriptional co‐activator with PDZ binding domain (TAZ) protein is strongly implicated in the pathogenesis of human cancer and is influenced by tumor metabolism. High levels of lactate concentration in the tumor microenvironment as a result of metabolic reprogramming are inversely correlated with patient overall survival. Herein, we investigated the role of lactate in the regulation of the activity of TAZ and showed that glycolysis‐derived lactate efficiently increased TAZ expression and activity in lung cancer cells. We showed that the reactive oxygen species (ROS) generated by lactate‐fueled oxidative phosphorylation (OXPHOS) in mitochondria activated AKT and thereby inhibited glycogen synthase kinase 3 beta/beta‐transducin repeat‐containing proteins (GSK‐3β/β‐TrCP)‐mediated ubiquitination and degradation of DNA methyltransferase 1 (DNMT1). Upregulation of DNMT1 by lactate caused hypermethylation of TAZ negative regulator of the LATS2 gene promoter, leading to TAZ activation. Moreover, TAZ binds to the promoter of DNMT1 and is necessary for DNMT1 transcription. Our study showed a molecular mechanism of DNMT1 in linking tumor metabolic reprogramming to the Hippo‐TAZ pathway and functional significance of the DNMT1‐TAZ feedback loop in the migratory and invasive potential of lung cancer cells.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v111.1
    DOI: 10.1111/cas.14246
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 15
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    Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
    Wiley ; 2023
    In:  Brain and Behavior
    Details
    In: Brain and Behavior, Wiley
    Abstract: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. Methods Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. Results In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. Conclusion These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Article
    DOI: 10.1002/brb3.3241
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2623587-0
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  • 16
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    Geological and climatic histories likely shaped the origins of terrestrial vertebrates endemic to the Tibetan Plateau
    Wiley ; 2021
    In:  Global Ecology and Biogeography Vol. 30, No. 5 ( 2021-05), p. 1116-1128
    Details
    In: Global Ecology and Biogeography, Wiley, Vol. 30, No. 5 ( 2021-05), p. 1116-1128
    Abstract: The Tibetan Plateau (TP) hosts many endemic species, but questions regarding when and from where these species originated have not been comprehensively answered. Here, we provide a synthesis of the biogeographical history of terrestrial vertebrates endemic to the TP and investigate the potential drivers of their spatio‐temporal origins. Location Tibetan Plateau and its surrounding regions. Time period Cenozoic. Major taxa studied Terrestrial vertebrates. Methods We used dispersal–extinction–cladogenesis models based on time‐calibrated phylogenies to reconstruct the ancestral ranges of 174 endemic TP species and compiled the ancestral ranges and age estimates of their dispersal events. We generated a possibility map of source areas for endemic TP species by counting the incidence of non‐TP sister clades in 110 km × 110 km grid cells. We used generalized linear mixed models to assess the relative importance of historical processes and environmental factors in explaining the geographical variations in the source areas. We created subsets based on four vertebrate classes to test whether the dispersal events varied spatially and temporally among taxonomic groups. Results We found that the endemic species colonized the TP as early as 55 Ma, and that the main colonization phase started to increase around 15 Ma and peaked after 6 Ma. The major source areas of endemic TP species include the Hengduan Mountains, the Himalayas, and Central Asia. Elevation difference had the strongest effect on the source areas, followed by geographical distance. The spatio‐temporal origins of species endemic to the TP and the potential drivers showed significant differences among vertebrate classes. Main conclusions Our study supports the hypothesis that endemic TP species originated from various zoogeographical regions at different times and highlights the important roles of the TP uplift and past climatic changes for determining the spatio‐temporal origins of endemic TP species.
    Type of Medium: Online Resource
    ISSN: 1466-822X , 1466-8238
    URL: Issue
    URL: Article
    DOI: 10.1111/geb.v30.5
    DOI: 10.1111/geb.13286
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1479787-2
    detail.hit.zdb_id: 2021283-5
    SSG: 12
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  • 17
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    The RxLR effector Avh241 from Phytophthora sojae requires plasma membrane localization to induce plant cell death
    Wiley ; 2012
    In:  New Phytologist Vol. 196, No. 1 ( 2012-10), p. 247-260
    Details
    In: New Phytologist, Wiley, Vol. 196, No. 1 ( 2012-10), p. 247-260
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.2012.196.issue-1
    DOI: 10.1111/j.1469-8137.2012.04241.x
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 18
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    Hyper‐reflective foci segmentation in SD‐OCT retinal images with diabetic retinopathy using deep convolutional neural networks
    Wiley ; 2019
    In:  Medical Physics Vol. 46, No. 10 ( 2019-10), p. 4502-4519
    Details
    In: Medical Physics, Wiley, Vol. 46, No. 10 ( 2019-10), p. 4502-4519
    Abstract: The purpose of this study was to automatically and accurately segment hyper‐reflective foci (HRF) in spectral domain optical coherence tomography (SD‐OCT) images with diabetic retinopathy (DR) using deep convolutional neural networks. Methods An automatic HRF segmentation model for SD‐OCT images based on deep networks was constructed. The model segmented small lesions through pixel‐wise predictions based on small image patches. We used an approach for discriminative features extraction for small patches by introducing small kernels and strides in convolutional and pooling layers, which was applied on the state‐of‐the‐art deep classification networks (GoogLeNet and ResNet). The features extracted by the adapted deep networks were fed into a softmax layer to produce the probabilities of HRF. We trained different models on a dataset with 16 HRF eyes by using different sizes of patches, and then, we fused these models to generate optimal results. Results Experimental results on 18 eyes demonstrated that our method is effective for the HRF segmentation. The dice similarity coefficient (DSC) for the foci area in B‐scan, projection images, and foci amount in B‐scan images reaches 67.81%, 74.09%, and 72.45%, respectively. Conclusions The proposed segmentation model can accurately segment HRF in SD‐OCT images with DR and outperforms traditional methods. Our model may provide reliable segmentations for small lesions in SD‐OCT images and may be helpful in the clinical diagnosis of diseases.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    URL: Issue
    URL: Article
    DOI: 10.1002/mp.v46.10
    DOI: 10.1002/mp.13728
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1466421-5
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  • 19
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    Low‐carbon evaluation of rural neighborhood: A case study of Yanhe Village, Hubei Province, China
    Wiley ; 2019
    In:  Growth and Change Vol. 50, No. 1 ( 2019-03), p. 247-265
    Details
    In: Growth and Change, Wiley, Vol. 50, No. 1 ( 2019-03), p. 247-265
    Abstract: Climate change has become a global issue influencing human survival and development while low‐carbon is the inevitable choice. As the world’s largest emitter of greenhouse gases, China has become an important force that influences the cooperation of climate change. China is a large agricultural country, and the rural carbon emissions have been gradually increasing. We consider rural neighborhood as an important space for the use of low‐carbon ideas to address climate change. There is no specific assessment system for a rural neighborhood. The studies of rural neighborhood low‐carbon mainly focus on the method of calculation carbon emissions. However, only quantifying rural carbon emissions is insufficient. In this paper, a low‐carbon evaluation indicator system has been proposed for rural neighborhood and Fuzzy Comprehensive Evaluation has been applied to get the low‐carbon degree. Considering the influence and feedback inside the indicator system, Analytic Network Process was applied to get the weights. Furthermore, a case study was carried out for the using of the proposed method in an eco‐village of China. Our practice has proved that the system is easy to operate in rural neighborhood.
    Type of Medium: Online Resource
    ISSN: 0017-4815 , 1468-2257
    URL: Issue
    URL: Article
    DOI: 10.1111/grow.2019.50.issue-1
    DOI: 10.1111/grow.12273
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 282764-5
    detail.hit.zdb_id: 1482672-0
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  • 20
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    LncRNA‐ATB mediated E‐cadherin repression promotes the progression of colon cancer and predicts poor prognosis
    Wiley ; 2016
    In:  Journal of Gastroenterology and Hepatology Vol. 31, No. 3 ( 2016-03), p. 595-603
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 31, No. 3 ( 2016-03), p. 595-603
    Abstract: Long non‐coding RNA‐activated by TGF‐β (lncRNA‐ATB) promotes the invasion–metastasis cascade in hepatocellular carcinoma via downregulating E‐cadherin (E‐cad) and inducing epithelial‐to‐ mesenchymal transition (EMT) and is clinically significant in human colon cancer. However, its molecular mechanisms in colon cancer progression remain unclear. This study aimed to elucidate the role of lncRNA‐ATB and its clinical value in colon cancer. Methods Expression levels of lncRNA‐ATB in colon cancer tissues and colon cancer cell lines were evaluated using quantitative real‐time polymerase chain reaction. The clinicopathological significance and prognostic value of lncRNA‐ATB were investigated, and roles of lncRNA‐ATB in regulating E‐cad and other EMT‐related markers expression and colon cancer progression were evaluated in vitro . Expression levels of lncRNA‐ATB and E‐cad in human plasma were evaluated. Results Long non‐coding RNA‐activated by TGF‐β was upregulated in colon cancer tissues compared with adjacent mucosa ( P   〈  0.001). LncRNA‐ATB levels were also higher in metastatic cancer tissues ( P   〈  0.001). Among the three highly invasive colon cancer cell lines, lncRNA‐ATB levels were relatively higher with concurrent low levels of E‐cad compared with levels in the three low‐invasive cell lines. LncRNA‐ATB expression correlated with pN stage ( P   〈  0.01) and American Joint Committee on Cancer stage ( P   〈  0.01). Striking differences were observed in overall survival and disease‐free survival in cases with both high lncRNA‐ATB expression and low E‐cad expression. Reduction of lncRNA‐ATB increased expression of epithelial markers E‐cad, ZO‐1, and decreased expression of mesenchymal markers ZEB1 and N‐cadherin (N‐cad), and significantly influenced colon cancer cell progression. Plasma lncRNA‐ATB was upregulated in colon cancer patients one month after surgery ( P   〈  0.05). Conclusions Long non‐coding RNA‐activated by TGF‐β may act on colon tumorigenesis by suppressing E‐cad expression and promoting EMT process, and lncRNA‐ATB inhibition may provide a promising therapeutic option for suppressing colon cancer progression.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2016.31.issue-3
    DOI: 10.1111/jgh.13206
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2006782-3
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