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  • 11
    In: Psycho-Oncology, Wiley, Vol. 26, No. 4 ( 2017-04), p. 537-543
    Abstract: Although one‐third of cancer patients are perceived to have a need for psychological support based on the percentage of mental disorders, little is known about the actual utilization of psychological care in cancer. We aimed to assess cancer patients' reported use of psychological care and its correlates in a large, representative sample. Methods In a multicenter, cross‐sectional study in Germany, 4020 cancer patients (mean age 58 years, 51% women) were evaluated. We obtained self‐reports of use of psychotherapy and psychological counseling. We measured distress with the Distress Thermometer, symptoms of depression with the Patient Health Questionnaire, anxiety with the Generalized Anxiety Disorder Scale, and social support with the Illness‐specific Social Support Scale. In a subsample of 2141, we evaluated the presence of a mental disorder using the Composite International Diagnostic Interview. Results In total, 28.9% (95% confidence interval 27.4%‐30.4%) reported having used psychotherapy or psychological counseling or both because of distress due to cancer. Independent correlates of utilization included age (odds ratio [OR] = 0.97 per year] , sex (male, OR = 0.55), social support (OR = 0.96), symptoms of depression (OR = 1.04) and anxiety (OR = 1.08), the diagnosis of a mental disorder (OR = 1.68), and a positive attitude toward psychosocial support (OR = 1.27). Less than half of those currently diagnosed with a mental disorder reported having taken up psychological support offers. Conclusion Special efforts should be made to reach populations that report low utilization of psychological care in spite of having a need for support.
    Type of Medium: Online Resource
    ISSN: 1057-9249 , 1099-1611
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1495115-0
    SSG: 5,2
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  • 12
    In: European Journal of Immunology, Wiley, Vol. 43, No. 3 ( 2013-03), p. 606-618
    Abstract: Similar to T‐helper (Th) cells, CD8 + T cells also differentiate into distinct subpopulations. However, the existence of IL‐9‐producing CD8 + T (Tc9) cells has not been elucidated so far. We show that murine CD8 + T cells activated in the presence of IL‐4 plus TGF‐β develop into transient IL‐9 producers characterized by specific IFN‐γ and IL‐10 expression patterns as well as by low cytotoxic function along with diminished expression of the CTL‐associated transcription factors T‐bet and Eomesodermin. Similarly to the CD4 + counterpart, Tc9 cells required for their differentiation STAT6 and IRF4. Tc9 cells deficient for these master regulators displayed increased levels of Foxp3 that in turn suppressed IL‐9 production. In an allergic airway disease model, Tc9 cells promoted the onset of airway inflammation, mediated by subpathogenic numbers of Th2 cells. This support was specific for Tc9 cells because CTLs failed to exert this function. We detected increased Tc9 frequency in the periphery in mice and humans with atopic dermatitis, a Th2‐associated skin disease that often precedes asthma. Thus, our data point to the existence of Tc9 cells and to their supportive function in Th2‐dependent airway inflammation, suggesting that these cells might be a therapeutic target in allergic disorders.
    Type of Medium: Online Resource
    ISSN: 0014-2980 , 1521-4141
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1491907-2
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  • 13
    In: Chemistry & Biodiversity, Wiley, Vol. 16, No. 5 ( 2019-05)
    Abstract: The lipophilization of β ‐ d ‐riboguanosine ( 1 ) with various symmetric as well as asymmetric ketones is described (→ 3a – 3f ). The formation of the corresponding O ‐2′,3′‐ketals is accompanied by the appearance of various fluorescent by‐products which were isolated chromatographically as mixtures and tentatively analyzed by ESI‐MS spectrometry. The mainly formed guanosine nucleolipids were isolated and characterized by elemental analyses, 1 H‐, 13 C‐NMR and UV spectroscopy. For a drug profiling, static topological polar surface areas as well as 10 log P OW values were calculated by an increment‐based method as well as experimentally for the systems 1‐octanol‐H 2 O and cyclohexane‐H 2 O. The guanosine‐ O ‐2′,3′‐ketal derivatives 3b and 3a could be crystallized in (D 6 )DMSO – the latter after one year of standing at ambient temperature. X‐ray analysis revealed the formation of self‐assembled ribbons consisting of two structurally similar 3b nucleolipid conformers as well as integrated (D 6 )DMSO molecules. In the case of 3a  ⋅ DMSO, the ribbon is formed by a single type of guanosine nucleolipid molecules. The crystalline material 3b  ⋅ DMSO was further analyzed by differential scanning calorimetry (DSC) and temperature‐dependent polarization microscopy. Crystallization was also performed on interdigitated electrodes (Au, distance, 5 μm) and visualized by scanning electron microscopy. Resistance and amperage measurements clearly demonstrate that the electrode‐bridging 3b crystals are electrically conducting. All O ‐2′,3′‐guanosine ketals were tested on their cytostatic/cytotoxic activity towards phorbol 12‐myristate 13‐acetate (PMA)‐differentiated human THP‐1 macrophages as well as against human astrocytoma/oligodendroglioma GOS‐3 cells and against rat malignant neuroectodermal BT4Ca cells.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2139001-0
    SSG: 12
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