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  • Wiley  (19)
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  • Wiley  (19)
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  • 1
    Online-Ressource
    Online-Ressource
    Zinc finger protein 335 mediates lipopolysaccharide‐induced neurodegeneration and memory loss as a transcriptional factor in microglia
    Wiley ; 2023
    In:  Glia
    Details
    In: Glia, Wiley
    Kurzfassung: Zinc finger protein 335 (Zfp335) is a transcription factor that regulates mammalian neurogenesis and neuronal differentiation. It is a causative factor for severe microcephaly, small somatic size, and neonatal death. Here, we evaluated the effects of Zfp335 in the adult mouse brain after lipopolysaccharide (LPS) challenge. We used wild‐type (WT) and Zfp335 knock‐down (Zfp335 +/− ) mice with LPS administered in the intracerebral ventricle in vivo and cultured microglia treated with LPS in vitro. The impact of Zfp335 was evaluated by RT‐PCR, RNA‐sequencing, western blotting, immunocytochemistry, ELISA, and the memory behavior tests. Knockdown of Zfp335 expression ameliorated microglia activation significantly, including reduced mRNA and protein expression of Iba1, reduced numbers of microglia, reduced cell diameter, and increased branch length, in the brains of 2‐month‐old mice after LPS treatment. Zfp335 was expressed in microglia and neurons, but increased in microglia, not neurons, in the brain of mice after LPS administration. LPS‐induced microglia‐mediated neurodegeneration was dependent upon microglial Zfp335 controlled by nuclear factor‐kappa B. Microglial Zfp335 affected neuronal activity through transcriptional regulation of lymphocyte antigen‐6M (Ly6M). Our data suggest that Zfp335 is a key transcription factor that exacerbates microglia‐mediated neurodegeneration through upregulation of Ly6M expression. Inhibition of microglial Zfp335 may be a new strategy for preventing brain disease induced by microglia activation.
    Materialart: Online-Ressource
    ISSN: 0894-1491 , 1098-1136
    URL: Article
    DOI: 10.1002/glia.24447
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 1474828-9
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Comparative transcriptome profiling analysis provides insight into the mechanisms for sugar change in Chinese jujube ( Ziziphus jujuba Mill.) under rain‐proof cultivation
    Wiley ; 2023
    In:  The Plant Genome Vol. 16, No. 2 ( 2023-06)
    Details
    In: The Plant Genome, Wiley, Vol. 16, No. 2 ( 2023-06)
    Kurzfassung: This study reveals molecular mechanisms for sugar change in Chinese jujube under rainproof cultivation. We predicted that ZjSPS, ZjSS, ZjHXK, and ZjINV play an important role in the change of sugar in jujube fruits. This study provides abundant genetic resources for the study of sugar accumulation metabolism of Chinese jujube.
    Materialart: Online-Ressource
    ISSN: 1940-3372 , 1940-3372
    URL: Issue
    URL: Article
    DOI: 10.1002/tpg2.v16.2
    DOI: 10.1002/tpg2.20341
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2440458-5
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    The effects of cellulose nanocrystal and dicumyl peroxide on the crystallization kinetics of polylactic acid
    Wiley ; 2023
    In:  Polymer Engineering & Science Vol. 63, No. 10 ( 2023-10), p. 3231-3242
    Details
    In: Polymer Engineering & Science, Wiley, Vol. 63, No. 10 ( 2023-10), p. 3231-3242
    Kurzfassung: Cellulose nanocrystals (CNCs) have been blended into polylactic acid (PLA) to improve the polymer's properties. The dispersion of CNC in the matrix has a strong influence on the properties of the nanocomposites. In this study, PLA and CNC were compounded by a reactive extrusion process using dicarbonyl peroxide (DCP) as the free radical initiator. Isothermal and non‐isothermal crystallization kinetics of the resulting nanocomposites were investigated to understand the effect of PLA‐D‐CNC on the crystallization of the materials. Nuclear magnetic resonance and Fourier transform infrared spectroscopy analyses confirmed the grafting of PLA onto CNC via reactive extrusion. The Avrami and Tobin model studies showed that the reactive extrusion product PLA‐D‐CNC exhibited much higher crystallization rates compared to neat PLA, PLA/CNC (without DCP), and PLA/DCP. The maximum crystallization rate temperature of PLA, PLA/CNC, and PLA/DCP was increased from ~100 to ~110°C for PLA‐D‐CNC. The results showed that CNC promoted PLA nucleation and crystallization at high temperatures under the action of DCP. Specifically, the maximum crystallization rate of PLA‐D‐CNC was 46 times higher than that of neat PLA. PLA‐D‐CNC showed a two‐stage crystallization process, while the other three samples exhibited mostly single‐stage processes. The much‐enhanced crystallization of PLA‐D‐CNC was ascribed to the improved interaction between PLA and PLA‐D‐CNC and the homogeneous dispersion of CNC. Highlights PLA chains were grafted onto CNC with the assistance of DCP free radicals. PLA‐grafted CNC facilitated heterogeneous nucleation of PLA. Crystallization studies confirmed improved PLA crystallization in the presence of PLA‐D‐CNC.
    Materialart: Online-Ressource
    ISSN: 0032-3888 , 1548-2634
    URL: Issue
    URL: Article
    DOI: 10.1002/pen.v63.10
    DOI: 10.1002/pen.26439
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2006718-5
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Transcranial magnetic stimulation over the right dorsolateral prefrontal cortex modulates visuospatial distractor suppression
    Wiley ; 2021
    In:  European Journal of Neuroscience Vol. 53, No. 10 ( 2021-05), p. 3394-3403
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 53, No. 10 ( 2021-05), p. 3394-3403
    Kurzfassung: Visual selective attention allows us to filter relevant inputs from irrelevant inputs during visual processing. In contrast to rich research exploring how the brain facilitates task‐relevant inputs, less is known about how the brain suppresses irrelevant inputs. In this study, we used transcranial magnetic stimulation (TMS) to investigate the causal role of the right dorsolateral prefrontal cortex (DLPFC), a crucial brain area for attentional control, in distractor suppression. Specifically, 10‐Hz repetitive TMS (rTMS) was applied to the right DLPFC and Vertex at the stimuli onset (stimuli‐onset TMS) or 500 ms prior to the stimuli onset (prestimuli TMS). In a variant of the Posner cueing task, participants were instructed to identify the shape of a white target while ignoring a white or colored distractor whose location was either cued in advance or uncued. As anticipated, either the location cue or the colored distractor led to faster responses. Notably, the location cueing effect was eliminated by stimuli‐onset TMS to the right DLPFC, but not by prestimuli TMS. Further analyses showed that stimuli‐onset TMS quickened responses to uncued trials, and this TMS effect was derived from the inhibition at the distractor in both visual fields. In addition, TMS over the right DLPFC had no specific effect on the colored distractor compared to the white one. Considered collectively, these findings indicate that the DLPFC plays a crucial role in visuospatial distractor suppression and acts upon stimuli presentation. Besides, it seems the DLPFC contributes more to location‐based distractor suppression than to color‐based one.
    Materialart: Online-Ressource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.v53.10
    DOI: 10.1111/ejn.15164
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2005178-5
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    How brain ‘cleaners’ fail: Mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease
    Wiley ; 2023
    In:  Glia
    Details
    In: Glia, Wiley
    Kurzfassung: Microglia are the resident phagocytes of the brain, where they primarily function in the clearance of dead cells and the removal of un‐ or misfolded proteins. The impaired activity of receptors or proteins involved in phagocytosis can result in enhanced inflammation and neurodegeneration. RNA‐seq and genome‐wide association studies have linked multiple phagocytosis‐related genes to neurodegenerative diseases, while the knockout of such genes has been demonstrated to exert protective effects against neurodegeneration in animal models. The failure of microglial phagocytosis influences AD‐linked pathologies, including amyloid β accumulation, tau propagation, neuroinflammation, and infection. However, a precise understanding of microglia‐mediated phagocytosis in Alzheimer's disease (AD) is still lacking. In this review, we summarize current knowledge of the molecular mechanisms involved in microglial phagocytosis in AD across a wide range of pre‐clinical, post‐mortem , ex vivo, and clinical studies and review the current limitations regarding the detection of microglia phagocytosis in AD. Finally, we discuss the rationale of targeting microglial phagocytosis as a therapeutic strategy for preventing AD or slowing its progression.
    Materialart: Online-Ressource
    ISSN: 0894-1491 , 1098-1136
    URL: Article
    DOI: 10.1002/glia.24465
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 1474828-9
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Automated segmentation of retinal nonperfusion area in fluorescein angiography in retinal vein occlusion using convolutional neural networks
    Wiley ; 2021
    In:  Medical Physics Vol. 48, No. 2 ( 2021-02), p. 648-658
    Details
    In: Medical Physics, Wiley, Vol. 48, No. 2 ( 2021-02), p. 648-658
    Kurzfassung: Retinal vein occlusion (RVO) is the second most common cause of vision loss after diabetic retinopathy due to retinal vascular disease. Retinal nonperfusion (RNP), identified on fluorescein angiograms (FA) and appearing as hypofluorescence regions, is one of the most significant characteristics of RVO. Quantification of RNP is crucial for assessing the severity and progression of RVO. However, in current clinical practice, it is mostly conducted manually, which is time‐consuming, subjective, and error‐prone. The purpose of this study is to develop fully automated methods for segmentation of RNP using convolutional neural networks (CNNs). Methods FA images from 161 patients were analyzed, and RNP areas were annotated by three independent physicians. The optimal method to use multi‐physicians’ labeled data to train the CNNs was evaluated. An adaptive histogram‐based data augmentation method was utilized to boost the CNN performance. CNN methods based on context encoder module were developed for automated segmentation of RNP and compared with existing state‐of‐the‐art methods. Results The proposed methods achieved excellent agreements with physicians for segmentation of RNP in FA images. The CNN performance can be improved significantly by the proposed adaptive histogram‐based data augmentation method. Using the averaged labels from physicians to train the CNNs achieved the best consensus with all physicians, with a mean accuracy of 0.883±0.166 with fivefold cross‐validation. Conclusions We reported CNN methods to segment RNP in RVO in FA images. Our work can help improve clinical workflow, and can be useful for further investigating the association between RNP and retinal disease progression, as well as for evaluating the optimal treatments for the management of RVO.
    Materialart: Online-Ressource
    ISSN: 0094-2405 , 2473-4209
    URL: Issue
    URL: Article
    DOI: 10.1002/mp.v48.2
    DOI: 10.1002/mp.14640
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 1466421-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease
    Wiley ; 2022
    In:  Aging Cell Vol. 21, No. 3 ( 2022-03)
    Details
    In: Aging Cell, Wiley, Vol. 21, No. 3 ( 2022-03)
    Kurzfassung: Regulation of neuroinflammation and β‐amyloid (Aβ) production are critical factors in the pathogenesis of Alzheimer's disease (AD). Cathepsin E (CatE), an aspartic protease, is widely studied as an inducer of growth arrest and apoptosis in several types of cancer cells. However, the function of CatE in AD is unknown. In this study, we demonstrated that the ablation of CatE in human amyloid precursor protein knock‐in mice, called APP NL−G−F mice, significantly reduced Aβ accumulation, neuroinflammation, and cognitive impairments. Mechanistically, microglial CatE is involved in the secretion of soluble TNF‐related apoptosis‐inducing ligand, which plays an important role in microglia‐mediated NF‐κB‐dependent neuroinflammation and neuronal Aβ production by beta‐site APP cleaving enzyme 1. Furthermore, cannula‐delivered CatE inhibitors improved memory function and reduced Aβ accumulation and neuroinflammation in AD mice. Our findings reveal that CatE as a modulator of microglial activation and neurodegeneration in AD and suggest CatE as a therapeutic target for AD by targeting neuroinflammation and Aβ pathology.
    Materialart: Online-Ressource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.v21.3
    DOI: 10.1111/acel.13565
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2099130-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    Photochemical Degradation of Organic Matter in the Atmosphere
    Wiley ; 2021
    In:  Advanced Sustainable Systems Vol. 5, No. 11 ( 2021-11)
    Details
    In: Advanced Sustainable Systems, Wiley, Vol. 5, No. 11 ( 2021-11)
    Kurzfassung: Organic matter in the gas‐phase and particles are important components of the atmosphere. Photochemical degradation is a major transformation pathway of atmospheric organic matter, which changes the atmospherically related life time and the environmental, climatic, and health‐related effects of organic matter, as well as biogeochemical cycles of elements. In addition to field observations and model simulations, laboratory experiments based on smog chambers and flow tubes are important approaches to study the photodegradation mechanisms and influencing factors of atmospheric organics. Isotopic composition is also a useful tracer for photodegradation processes of different organics, for example, carboxylic acids. In this article, research progress on photodegradation of several significant categories of organic pollutants which have aroused widespread concern currently, for example, polycyclic aromatic hydrocarbons, carboxylic acids, brown carbon, organosulfates/organonitrates, microplastics, and bioaerosols, are reviewed. The effects of different degradation mechanisms including photochemical reactions, heterogeneous aqueous reactions, and microbial degradation are also compared. Although the photodegradation of atmospheric organics has been studied to a certain extent, much more effort should be made to fill the large knowledge gap between the actual and simulated photodegradation processes.
    Materialart: Online-Ressource
    ISSN: 2366-7486 , 2366-7486
    URL: Issue
    URL: Article
    DOI: 10.1002/adsu.v5.11
    DOI: 10.1002/adsu.202100027
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2880982-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Ultrahigh Sensitivity Solar‐Blind UV Detection via Multistage‐Concentric‐Annulus Architecture Metasurface
    Wiley ; 2024
    In:  Advanced Optical Materials Vol. 12, No. 2 ( 2024-01)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 12, No. 2 ( 2024-01)
    Kurzfassung: High‐sensitivity photodetection capability has become an indispensable requirement for detecting feeble solar‐blind ultraviolet (UV) light. Micro‐nano metallic metasurface structures are employed to enhance the detector photoelectric performances. However, existing approaches are confronted with bottlenecks of structure simplification and efficacy mediocrity. Here, a distinctive diamond solar‐blind UV photodetector with a synthetic multistage‐concentric‐annulus (MCA) architecture metasurface is reported, which is prepared through a facile and peculiar Fraunhofer diffraction technique. The detector achieves an excellent photo‐to‐dark‐current ratio of 2.4×10 8 and maintains an extremely low dark current on the order of pA magnitude. The intrinsic response peak and resonance absorption phenomenon in solar‐blind UV are evident from the optical properties. Moreover, the surface potential distribution intuitively reveals that plasmon resonance enhances the UV scattering and absorption cross sections, thus facilitating the photogeneration of carriers. Meanwhile, it expressly demonstrates that multi‐level dipole interaction in the MCA structure accelerates the separation and extraction of electron–hole pairs through enhancing the localized electric field intensity. In addition, a wide range of variable temperature measurements further prove the device possesses capacity for working in extreme environments. This photodetection technology by virtue of a delicate and viable diffraction metasurface is anticipated to provide a leap forward for future applications in wide‐band‐gap semiconductor UV detectors.
    Materialart: Online-Ressource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v12.2
    DOI: 10.1002/adom.202301333
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2024
    ZDB Id: 2708158-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Structural Color: Encoding Localized Strain History Through Wrinkle Based Structural Colors (Adv. Mater. 39/2010)
    Wiley ; 2010
    In:  Advanced Materials Vol. 22, No. 39 ( 2010-10-15), p. n/a-n/a
    Details
    In: Advanced Materials, Wiley, Vol. 22, No. 39 ( 2010-10-15), p. n/a-n/a
    Materialart: Online-Ressource
    ISSN: 0935-9648
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v22:39
    DOI: 10.1002/adma.201090128
    RVK:
    UA 1538
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2010
    ZDB Id: 1474949-X
    Standort Signatur Einschränkungen Verfügbarkeit
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