In:
British Journal of Haematology, Wiley, Vol. 187, No. 4 ( 2019-11), p. 459-469
Abstract:
Renal involvement is found in about 70% of patients with systemic immunoglobulin light‐chain (AL) amyloidosis. However, there is no risk stratification system specialized for renal AL concerning patients’ survival. Galectin‐3 (Gal‐3) has been reported to portend poor prognosis in other renal diseases. We measured Gal‐3 and several traditional risk biomarkers of AL in baseline samples from 253 consecutive patients diagnosed with renal AL. At baseline, Gal‐3 [Hazard ratio (HR): 1·46; P = 0·033], high‐sensitivity cardiac troponin T (hs‐cTnT) (HR: 2·65; P 〈 0·001) and difference between involved and uninvolved free light chains (dFLC) (HR: 1·81; P = 0·001) were independent predictors of all‐cause mortality. The cut‐off points for Gal‐3, hs‐cTnT, and dFLC were 20·24 ng/ml, 0·026 ng/ml, and 75·89 mg/l, respectively. Patients were stratified into four stages by assigning a score of 1 for each of the three biomarkers above the cut‐off point. The proportions of patients with disease stages 1, 2, 3 and 4 were 17·0%, 37·2%, 29·2% and 16·6%, and the median overall survival times from diagnosis were 100, 60, 29 and 15 months, respectively ( P 〈 0·01). Higher level of Gal‐3 is associated with increased risk for mortality, and the risk stratification based on Gal‐3 is a reliable model for predicting mortality in AL amyloidosis with renal involvement.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1475751-5
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