In:
Acta Obstetricia et Gynecologica Scandinavica, Wiley, Vol. 93, No. 7 ( 2014-07), p. 661-668
Abstract:
To compare tumor characteristics and clinical outcome of patients with cervical locally advanced adenocarcinoma ( AC )/adenosquamous carcinoma ( ASC ) and squamous cell carcinoma ( SCC ). Design Retrospective study. Setting National Taiwan University Hospital, Taipei, Taiwan. Population All patients with cervical SCC ( n = 35), AC or ASC ( n = 194) with FIGO stage ≥IIB who received definitive radiotherapy or concurrent chemoradiotherapy ( CCRT ) from January 1995 to December 2009. Method Medical and histopathological record review. Main outcome measures Progression‐free survival ( PFS ), local recurrence‐free survival, distant metastasis‐free survival, and overall survival ( OS ). Results Compared with the SCC subgroup, patients with AC / ASC were significantly younger ( p = 0.007), more of them without clinical symptoms were diagnosed by abnormal Pap smear findings ( p = 0.043), and less responded to treatment ( p = 0.018). After a median follow‐up of 59.3 months, patients with AC / ASC had worse 5‐year PFS (30.0% vs. 47.6%, p = 0.044), worse 5‐year distant metastasis‐free survival (41.5% vs. 69.9%, p = 0.005), and trends toward worse 5‐year local recurrence‐free survival (64.4% vs. 76.2%, p = 0.165) and worse 5‐year OS (41.3% vs. 58.1%, p = 0.090) than patients with SCC . In univariate analysis, early FIGO stage and complete treatment response were significantly associated with PFS and OS . Histology of non‐ AC / ASC and Point A biologically equivalent doses in 2‐Gy fractions 〉 85 Gy were significantly associated with better PFS , and CCRT was significantly associated with better OS . In multivariate analysis, complete treatment response and early FIGO stage remained significant factors for predicting better PFS and OS . Conclusions Cervical AC / ASC may be more aggressive than is SCC . For cervical AC / ASC , more comprehensively effective treatments are warranted.
Type of Medium:
Online Resource
ISSN:
0001-6349
,
1600-0412
DOI:
10.1111/aogs.2014.93.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2024554-3
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