In:
Angewandte Chemie, Wiley, Vol. 130, No. 5 ( 2018-01-26), p. 1390-1394
Abstract:
Reported is a highly enantioselective copper‐catalyzed Markovnikov protoboration of unactivated terminal alkenes. A variety of simple and abundant feedstock α‐olefins bearing a diverse array of functional groups and heterocyclic substituents can be used as substrates, and the reaction proceeds under mild reaction conditions at ambient temperature to provide expedient access to enantioenriched alkylboronic esters in good regioselectivity and with excellent enantiocontrol. Critical to the success of the protocol was the development and application of a novel, sterically hindered N‐heterocyclic carbene, ( R , R , R , R )‐ANIPE, as the ligand for copper.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.201711229
Language:
English
Publisher:
Wiley
Publication Date:
2018
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514305-6
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505872-7
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1479266-7
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506259-7
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