In:
Angewandte Chemie, Wiley, Vol. 130, No. 19 ( 2018-05-04), p. 5448-5452
Abstract:
An organocatalytic system is presented for the Michael addition of monoactivated glycine ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group, which increases the acidity of the methylene hydrogen atoms and enhances the reactivity, thus allowing the synthesis of a large variety of α,γ‐diamino acid derivatives with excellent stereoselectivity.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.19
DOI:
10.1002/ange.201800435
Language:
English
Publisher:
Wiley
Publication Date:
2018
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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