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  • Wiley  (4)
  • Chemistry/Pharmacy  (4)
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  • Wiley  (4)
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  • Chemistry/Pharmacy  (4)
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  • 1
    Online Resource
    Online Resource
    Mycophenolic Acid: Biogenesis, Compound Isolation, Biological Activity, and Historical Advances in Total Synthesis
    Wiley ; 2019
    In:  European Journal of Organic Chemistry Vol. 2019, No. 13 ( 2019-04-09), p. 2315-2334
    Details
    In: European Journal of Organic Chemistry, Wiley, Vol. 2019, No. 13 ( 2019-04-09), p. 2315-2334
    Abstract: The 6‐alkyl‐2,4‐dihydroxybenzoate moiety known commonly as resorcylate occurs widely as a building block in various fused cyclic systems of bioactive natural products and analogues. Among these many isolated active molecules, mycophenolic acid (MPA) was one of the most studied for its structural features and its potential biological activity. This perspective article portrays the unique biosynthetic interrelationships of polyketide formations in to resorcylates, which are implemented by recent biomimetic/chemical synthetic investigations of the natural product target. The resorcylate, MPA have remained as interesting targets for total synthesis in many laboratories worldwide. There are 13 syntheses reported for MPA to date (Scifinder search). The synthetic strategies for this potential lead compound was an evolution of various methods from generating the highly‐substituted aromatic system via employing simple and commercially available materials to the catalytic methods employed which always involve linear sequences; convergent approaches to the most important protecting group‐free syntheses are also briefly documented in this critical review. This natural product has been the subject of considerable synthetic study. Most reported total syntheses employ 6‐alkyl‐2,4‐hydroxybenzoic acids (lactones) as intermediates and proceed via stepwise derivatization to introduce other functionalities.
    Type of Medium: Online Resource
    ISSN: 1434-193X , 1099-0690
    URL: Issue
    URL: Article
    DOI: 10.1002/ejoc.v2019.13
    DOI: 10.1002/ejoc.201900245
    RVK:
    VA 4073
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1475010-7
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Transition‐Metal‐Free Regioselective Alkylation of Pyridine N ‐Oxides Using 1,1‐Diborylalkanes as Alkylating Reagents
    Wiley ; 2016
    In:  Angewandte Chemie Vol. 128, No. 33 ( 2016-08-08), p. 9842-9846
    Details
    In: Angewandte Chemie, Wiley, Vol. 128, No. 33 ( 2016-08-08), p. 9842-9846
    Abstract: Reported herein is an unprecedented base‐promoted deborylative alkylation of pyridine N‐oxides using 1,1‐diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N‐oxides and 1,1‐diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C−H arylation and methylation of pyridine N‐oxides. The reaction also can be applied for the direct introduction of a methyl group to 9‐O‐methylquinine N‐oxide, thus it can serve as a powerful method for late‐stage functionalization.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v128.33
    DOI: 10.1002/ange.201603329
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Transition‐Metal‐Free Regioselective Alkylation of Pyridine N ‐Oxides Using 1,1‐Diborylalkanes as Alkylating Reagents
    Wiley ; 2016
    In:  Angewandte Chemie International Edition Vol. 55, No. 33 ( 2016-08-08), p. 9690-9694
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 55, No. 33 ( 2016-08-08), p. 9690-9694
    Abstract: Reported herein is an unprecedented base‐promoted deborylative alkylation of pyridine N‐oxides using 1,1‐diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N‐oxides and 1,1‐diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C−H arylation and methylation of pyridine N‐oxides. The reaction also can be applied for the direct introduction of a methyl group to 9‐O‐methylquinine N‐oxide, thus it can serve as a powerful method for late‐stage functionalization.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v55.33
    DOI: 10.1002/anie.201603329
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Phase formation and spectral evolution of (Sr,Ba) 2 Si(O,N) 4 :Eu 2+ phosphors
    Wiley ; 2017
    In:  Journal of the American Ceramic Society Vol. 100, No. 5 ( 2017-05), p. 2136-2143
    Details
    In: Journal of the American Ceramic Society, Wiley, Vol. 100, No. 5 ( 2017-05), p. 2136-2143
    Abstract: Sr 2‐ x B a x Si(O,N) 4 :Eu 2+ ( SB x SON :Eu 2+ ) oxynitridosilicate phosphors were prepared via incorporation of N 3− , Eu 2+ , and Ba 2+ ions into Sr 2 SiO 4 ( SSO ) lattices. X‐ray diffraction patterns of the prepared powders revealed that SB x SON :Eu 2+ was a solid‐solution form of SSO . An increase in x values caused a phase transition and an expansion of the unit cell. The photoluminescence excitation ( PLE ) spectra of SB x SON :Eu 2+ were broad, covering the ultraviolet range to the visible range. Corresponding PL emission spectra strongly depended on the excitation wavelengths and consisted of two emission bands, one in the green‐blue region (A‐band) and the other in the red region (B‐band), which were assigned to Eu(I) and Eu( II ), respectively. The B‐band resulted from a dramatic red‐shift of the green emission band assigned to Eu( II ) of SSO :Eu 2+ , revealing that the nitridation process preferentially affected the Eu( II ) sites. This behavior was explained by crystal field splitting, the fluorescence decay time, and thermal quenching. The Ba 2+ substitution caused evolution of the PL spectra, and its effects on the spectra were discussed under consideration of ionic size and covalence.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    URL: Article
    DOI: 10.1111/jace.2017.100.issue-5
    DOI: 10.1111/jace.14643
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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