In:
FEBS Letters, Wiley, Vol. 590, No. 9 ( 2016-05), p. 1304-1312
Abstract:
In humans, a considerable fraction of the retinoid pool in skin is derived from vitamin A 2 (all‐ trans 3,4‐dehydroretinal). Vitamin A 2 may be locally generated by keratinocytes, which can convert vitamin A 1 (all‐ trans retinol) into vitamin A 2 in cell culture. We report that human cytochrome P450 (hP450) 27C1, a previously ‘orphan’ enzyme, can catalyze this reaction. Purified recombinant hP450 27C1 bound and desaturated all‐ trans retinol, retinal, and retinoic acid, as well as 11‐ cis ‐retinal. Although the physiological role of 3,4‐dehydroretinoids in humans is unclear, we have identified hP450 27C1 as an enzyme capable of efficiently mediating their formation.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/1873-3468.12167
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1460391-3
SSG:
12
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