In:
The Journal of Physiology, Wiley, Vol. 598, No. 13 ( 2020-07), p. 2575-2587
Abstract:
Despite growing interest in right ventricular form and function in diseased states, there is a paucity of data regarding characteristics of right ventricular function – namely contractile and lusitropic reserve, as well as ventricular‐arterial coupling, in the healthy heart during rest, as well as submaximal and peak exercise. Pressure‐volume analysis of the right ventricle, during invasive cardiopulmonary exercise testing, demonstrates that that the right heart has enormous contractile reserve, with a three‐ or fourfold increase in all metrics of contractility, as well as myocardial energy production and utilization. The healthy right ventricle also demonstrates marked augmentation in lusitropy, indicating that diastolic filling of the right heart is not passive. Rather, the right ventricle actively contributes to venous return during exercise, along with the muscle pump. Ventricular‐arterial coupling is preserved during submaximal and peak exercise in the healthy heart.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475290-6
SSG:
12
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