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  • 1
    Online Resource
    Online Resource
    Portal hypertension may influence the registration of hypointensity of small hepatocellular carcinoma in the hepatobiliary phase in gadoxetic acid MR
    Walter de Gruyter GmbH ; 2022
    In:  Radiology and Oncology Vol. 56, No. 3 ( 2022-08-14), p. 292-302
    Details
    In: Radiology and Oncology, Walter de Gruyter GmbH, Vol. 56, No. 3 ( 2022-08-14), p. 292-302
    Abstract: The aim of the study was to analyze the association between the liver uptake of Gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in the hepatobiliary phase (HBP) in cirrhotic patients and the presence of clinically significant portal hypertension (CSPH), and how these features impact on hepatocellular carcinoma (HCC) detection in the HBP. Patients and methods Post-hoc analysis of a prospective cohort of 62 cirrhotic patients with newly US-detected nodule between 1–2 cm (study group). Twenty healthy subjects were used as control group. Qualitative and quantitative analysis of the liver contrast uptake in the HBP assessed by Relative Liver-Enhancement (RLE), Liver-Spleen (LSCR), Liver-Muscle (LMCR), and Liver-Kidney Contrast-Ratio (LKCR), Contrast Enhancement Index (CEI), and Hepatic Uptake (HUI), and biliary excretion, were registered. CSPH was confirmed invasively (HVPG 〉 10 mmHg) or by indirect parameters. The appearance of HCC at the HBP was analyzed. Results Nineteen patients (30.6%) did not have CSPH. In 41 patients (66.1%) the final diagnosis was HCC. All indices were significantly higher in the control group, indicating a more intense HBP liver signal intensity compared to patients with cirrhosis, even if the comparison was restricted to patients with no CSPH. CSPH was associated to a lower rate of HCC hypointensity in the HBP (51.9% vs . 85.7% without CSPH, p = 0.004). Conclusions Liver uptake of Gd-EOB-DTPA at the HBP is decreased in cirrhosis even if the liver function is minimally impaired and it falls down significantly in patients with CSPH compromising the recognition of hypointense lesions. This fact may represent a limitation for the detection of small HCC in patients with cirrhosis and CSPH.
    Type of Medium: Online Resource
    ISSN: 1581-3207
    URL: Article
    DOI: 10.2478/raon-2022-0024
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2022
    detail.hit.zdb_id: 2134813-3
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  • 2
    Online Resource
    Online Resource
    Present trends in the encapsulation of anticancer drugs
    Walter de Gruyter GmbH ; 2023
    In:  Physical Sciences Reviews Vol. 8, No. 2 ( 2023-02-22), p. 327-344
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    In: Physical Sciences Reviews, Walter de Gruyter GmbH, Vol. 8, No. 2 ( 2023-02-22), p. 327-344
    Abstract: Different nanomedicine devices that were developed during the recent years can be suitable candidates for their application in the treatment of various deadly diseases such as cancer. From all the explored devices, the nanoencapsulation of several anticancer medicines is a very promising approach to overcome some drawbacks of traditional medicines: administered dose of the drugs, drug toxicity, low solubility of drugs, uncontrolled drug delivery, resistance offered by the physiological barriers in the body to drugs, among others. In this chapter, the most important and recent progress in the encapsulation of anticancer medicines is examined: methods of preparation of distinct nanoparticles (inorganic nanoparticles, dendrimers, biopolymeric nanoparticles, polymeric micelles, liposomes, polymersomes, carbon nanotubes, quantum dots, and hybrid nanoparticles), drug loading and drug release mechanisms. Furthermore, the possible applications in cancer prevention, diagnosis, and cancer therapy of some of these nanoparticles have been highlighted.
    Type of Medium: Online Resource
    ISSN: 2365-659X
    URL: Article
    DOI: 10.1515/psr-2020-0080
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
    detail.hit.zdb_id: 2864634-4
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