In:
ract, Walter de Gruyter GmbH, Vol. 101, No. 9 ( 2013-09), p. 595-600
Abstract:
Retaining radioactive daughter products at a clinically relevant target site remains one of the major challenges in development of in vivo α generators with radionuclides such as 225 Ac and 223 Ra. In this work, we examine the ability of layered nanoparticle constructs to retain 225 Ac and the first decay daughter, 221 Fr. Actinium-225 is cocrystalized in a lanthanide phosphate nanoparticle consisting of varying amounts of La and Gd. Additional lanthanide phosphate layers improve retention capability while an outer layer of gold facilitates the attachment of targeting moieties for in vivo use. Retention of 225 Ac in the nanoparticles is near quantitative while the 221 Fr retention varies from 60-89% as a function of time, the number of layers, and nanoparticle composition. Decay corrected radiochemical yield in the multi-shell syntheses are high (76%) and comparable to or better than existing delivery approaches.
Type of Medium:
Online Resource
ISSN:
2193-3405
,
0033-8230
DOI:
10.1524/ract.2013.2066
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2013
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