In:
Radiochimica Acta, Walter de Gruyter GmbH, Vol. 107, No. 9-11 ( 2019-09-25), p. 1065-1085
Abstract:
The use of α-emitting radionuclides in targeted alpha therapy (TAT) holds great potential for treatment of human diseases, such as cancer, due to the short pathlength and high potency of the α particle, which can localize damage to targeted cells while minimizing effects to healthy surrounding tissues. In this review several potential α-emitting radionuclides having emission properties applicable to TAT are discussed from a radiochemical point of view. Overviews of production, radiochemical separation and chelation aspects relative to developing TAT radiopharmaceuticals are provided for the α-emitting radionuclides (and their generator systems) 211 At, 224 Ra/ 212 Pb/ 212 Bi, 225 Ac/ 213 Bi, 227 Th/ 223 Ra, 230 U/ 226 Th, 149 Tb and 255 Fm.
Type of Medium:
Online Resource
ISSN:
2193-3405
,
0033-8230
DOI:
10.1515/ract-2019-0005
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2019
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