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  • Vietnam National University Journal of Science  (13)
  • 1
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    Lignans from Gymnema Sylvestre
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Natural Sciences and Technology ( 2022-10-12)
    Details
    In: VNU Journal of Science: Natural Sciences and Technology, Vietnam National University Journal of Science, ( 2022-10-12)
    Abstract: Seven known lignans, tortoside A (1), (+)-syringaresinol (2), (+)-medioresinol (3), (+)-pinoresinol (4), (+)-lyoniresin-6-yl β-D-glucopyranoside (5), (-)-lyoniresinol 3α-O-β-D-glucopyranoside (6), and (-)-lyoniresinol (7) were isolated from the leaves of Gymnema sylvestre (Retz.) R.Br. ex Schult. Their structures were identified on the basis of spectroscopic evidence and in comparison with those reported in the literature. All compounds were reported from G. sylvestre for the first time.
    Type of Medium: Online Resource
    ISSN: 2588-1140 , 2615-9317
    URL: Article
    DOI: 10.25073/2588-1140/vnunst.5365
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 2
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    Removal of Phenol from Water by Commercial Coconut Shell Charcoal
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Natural Sciences and Technology ( 2023-05-15)
    Details
    In: VNU Journal of Science: Natural Sciences and Technology, Vietnam National University Journal of Science, ( 2023-05-15)
    Abstract: In this study, phenol was adsorbed by commercial coconut shell charcoal (CSC), which is inexpensive, commercially available, non-toxic, and environmentally friendly. The measurements, namely the density functional theory (DFT) calculation, the energy-dispersive X-ray spectroscopy (EDS), and the Fourier-transform infrared spectroscopy (FTIR), were conducted to characterize the features of the CSC. The highest phenol removal efficiency reached 78.62% at optimal conditions (pH: 7, initial concentration of phenol: 20 mg/L, adsorption time: 120 minutes, and dosage of CSC: 2.5 g/L). The phenol adsorption process follows the Langmuir adsorption model with the coefficient R2 = 0.9964. The maximum adsorption capacity by the CSC was determined to be 14.32 mg/g. The process of desorption of phenol from CSC was most effective in the NaOH solution. On the other hand, the adsorption efficiency of CSC gradually decreased after five consecutive cycles. At the fifth use, the phenol uptake efficiency reached 22.2%.
    Type of Medium: Online Resource
    ISSN: 2588-1140 , 2615-9317
    URL: Article
    DOI: 10.25073/2588-1140/vnunst.5515
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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  • 3
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    Evaluation of the Ability to Treat Saline and Acid Sulfate Soils of Biochar from Rice Husks in Greenhouse Conditions
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Earth and Environmental Sciences Vol. 38, No. 3 ( 2022-09-26)
    Details
    In: VNU Journal of Science: Earth and Environmental Sciences, Vietnam National University Journal of Science, Vol. 38, No. 3 ( 2022-09-26)
    Abstract: The purposes of this study were to i) Examine the dynamics of physicochemical parameters of saline acid sulfate soil as influenced by biochar made from rice husk; and ii) Evaluate the influence of biochar on the soil quality index. A greenhouse experiment was carried out by mixing biochar with the tested soil at ratios of 0; 0.7; 1.5; 3, and 6% (w/w) and incubating for 100 days. Experimental soil samples were taken on days 5, 15, 30, 60, and 100 to analyze for 11 physicochemical parameters. The soil quality index (SQI) was calculated based on the principal component/factor analysis (PCA/FA). The results showed that biochar increased the exchangeable concentration of K, Mg, Ca, and pH value while reducing the exchangeable concentration of Fe, and Al, as well as the values of Cl-, H+, and exchange acidity in the soil. Biochar changed the electrical conductivity (EC) and Na parameters, increasing them in the first few measurements while decreasing them in the last measurements. Biochar increased the SQI of the tested soil, even with a low biochar application rate of 0.7% after 100 days of the experiment. The study suggests that biochar made from rice husk could be a potential amendment for ameliorating saline acid sulfate soil.  
    Type of Medium: Online Resource
    ISSN: 2588-1094 , 2615-9279
    URL: Article
    DOI: 10.25073/2588-1094/vnuees.4871
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 4
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    Berberine: A Perspective Compound in the Development of New Medicines
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 4 ( 2022-12-18)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 4 ( 2022-12-18)
    Abstract: Berberine (BBR) is a plant-origin alkaloid with a long history, commonly used for treating infectious diarrhea. In recent years, BBR has been found with many pharmacological effects such as lowering blood glucose, anti-hyperlipidemia, liver protection, kidney protection, anti-atherosclerosis, antioxidants, etc. However, several studies revealed that the oral bioavailability of BBR was very low. Therefore, drug delivery systems have been studied to improve the absorption of BBR through an intestinal epithelial barrier such as liposomes, proliposomes, phytosomes, and nano lipids. The finding of new drug delivery systems has great potential in developing new medicines with a traditional active substance – BBR. Besides, BBR is also an important lead compound with different pharmacological effects, promising to form many new drug discovery programs with high feasibility.  
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4452
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 5
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    Morphological and Microscopical Characteristics of Oxalis corniculata L.
    Vietnam National University Journal of Science ; 2021
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 37, No. 1 ( 2021-03-10)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 37, No. 1 ( 2021-03-10)
    Abstract: Morphological and microscopical characteristics of “Chua me dat hoa vang” collected in Ha Tinh province were studied. Results have identified the scientific name of the plant as Oxalis corniculata L. (family Oxalidaceae). Besides, the morphological characteristics and powder microscopy of leaf and stem of Oxalis corniculata L. species were established. Morphological characteristics of leaf and stem are pale yellow corolla, slightly pointed bracts and cube calcium oxalate crystals scattered in the soft tissue of the leaf. characteristics of herbal powder are twisted vascular grafts, hairs unicellular. Keywords Oxalis corniculata, Oxalis corniculata L., Oxalis, Oxalidaceae, morphological characteristics, microscopical characteristics. References [1] D.H. Bich, D.Q. Chung, B.X. Chuong, N.T. Dong, D.T. Dam, P.V. Hien, V.N. Lo, P.D. Mai, P.K. Man, D.T. Nhu, N. Tap, T. Toan, Medicinal plants and animals in Vietnam, Volume I, Science and Technology Publishing House, Hanoi, 2004. (in Vietnamese)[2] M. Ibrahim, I. Hussain, M. Imran, N. Hussain, A. Hussain, T. Mahboob, Corniculatin A, a new flavonoidal glucoside from Oxalis corniculata, Revista Brasileira de Farmacognosia 23(4) (2013) 630-634. https://doi.org/10.1590/S0102- https://doi.org/10.1590/S0102695X2013005000059.[3] K.C. Oberlander, E. Emshwiller, D.U. Bellstedt, L.L. Dreyer, A model of bulb evolution in the eudicot genus Oxalis (Oxalidaceae), Molecular Phylogenetics and Evolution 51(1) (2009) 54–63. https://doi.org/10.1016/j.ympev.2008.11.022.[4] J. Zietsman, L.L. Dreyer, B. Jansen, V. Vuuren, Genetic differentiation in Oxalis (Oxalidaceae): A tale of rarity and abundance in the Cape Floristic Region, South African Journal of Botany, 75(1) (2009) 27–33. https://doi.org/10.1016/j.sajb.2008.06.003[5] L.D. Bich, Good folk remedies, Ethnic Culture Publishing House, Hanoi, 2000 (in Vietnamese).[6] L.D. Bich, T.V. On, Botany, Medical Publishing House, Hanoi, 2007 (in Vietnamese).[7] D.T. Loi, Vietnamese medicinal plants and herbs, Medical Publishing House, Hanoi, 2005 (in Vietnamese).[8] N.V. Than, Laboratory of Medicinal Materials by microscopic method, Science and Technology Publishing House, Hanoi, 2003 (in Vietnamese).      
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4276
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2021
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  • 6
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    Genetic Diversity and Haplogroup Distribution of Three Ethnic Groups Tay, Thai, and Nung
    Vietnam National University Journal of Science ; 2024
    In:  VNU Journal of Science: Natural Sciences and Technology ( 2024-05-14)
    Details
    In: VNU Journal of Science: Natural Sciences and Technology, Vietnam National University Journal of Science, ( 2024-05-14)
    Abstract: The mitochondrial genome, with outstanding characteristics such as maternal inheritance, non-recombination and high mutation rate, is of great importance in population genetics and evolution research. To study the genetic diversity and the distribution of haplogroups of the Tai – Kadai language group, blood samples of 108 men from three ethnic groups Tay, Thai and Nung were collected. Total DNA extracted from blood samples was used for library preparation and whole mitochondrial genome sequencing using NGS. Comparing the obtained mitochondrial genome sequence with the RSRS (Reconstructed Sapiens Reference sequence) from Genbank (NC_012920) revealed 3929 distinct variants  in 108 individuals with 1663 variants in the Tay ethnic group, 905 variants in the Thai ethnic group and 1361 variants in the Nung ethnic group. Nucleotide diversity (π) and haplotype were highest in the Thai ethnic group, being 0.0023 and 0.989, respectively. The genetic distances between each ethnic group pair (Tay-Nung, Tay-Thai and Thai-Nung), as shown by the FST values, were 0.03101; 0.00447 and 0.03282, respectively. Haplogroup analysis showed that 108 studied individuals belonged to 33 different haplogroups, belonging to 2 groups of haplogroups M and N. The most frequent haplogroups in Tay Thai and Nung were B4, F1 and M7, respectively. The results of this study show that although belonging to the same Tai - Kadai language family, the mitochondrial genomes among the three ethnic groups Tay, Thai, and Nung still have notable differences.
    Type of Medium: Online Resource
    ISSN: 2588-1140 , 2615-9317
    URL: Article
    DOI: 10.25073/2588-1140/vnunst.5527
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2024
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  • 7
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    Excess Conductivity Analyses in Bi-Pb-Sr-Ca-Cu-O Systems Sintered at Different Temperatures
    Vietnam National University Journal of Science ; 2021
    In:  VNU Journal of Science: Mathematics - Physics Vol. 37, No. 4 ( 2021-12-03)
    Details
    In: VNU Journal of Science: Mathematics - Physics, Vietnam National University Journal of Science, Vol. 37, No. 4 ( 2021-12-03)
    Abstract: This paper studies the effects of the sintering temperature on crystal structure, critical temperature (Tc) and excess conductivity of Bi-Pb-Sr-Ca-Cu-O (BPSCCO) system. Bulk BPSCCO samples were fabricated by the solid-state reaction method. Four different temperatures of 835 °C, 840 °C, 845 °C, and 850 °C were applied to sinter four different samples. The crystal structure of the samples was investigated through X-ray diffraction measurements (XRD) and scanning electron microscopy (SEM). Superconductivity of the samples was analyzed by the temperature-dependent resistivity measurement. The experimental results showed the existence of both Bi-2223 and Bi-2212 phases in all samples. Quantitatively, the volume fraction of the Bi-2223 phase was found to increase from 53.56% to 75.97%, and the average grain size of Bi-2223 phase was observed to enlarge from 57.95 nm to 86.50 nm as the sintering temperature increased from 835 °C to 850 °C. In addition, the excess conductivity analyses based on the theory of Aslamazov - Larkin (AL) and Lawrence - Doniach (LD) showed decreases in the coherence lengths (ξc(0)) from 1.957 Å to 1.565 Å and the effective inter-layering spacing (d) from 79.7 Å to 64.5 Å. Meanwhile, the interlayer coupling strength (J) between two CuO2 planes was estimated to increase from 0.00083 to 0.00137. These results might be evidence to conclude that the increasing of the sintering temperature obviously improves the superconductivity in the BPSCCO system.    
    Type of Medium: Online Resource
    ISSN: 2588-1124 , 2615-9341
    URL: Article
    DOI: 10.25073/2588-1124/vnumap.4602
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2021
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  • 8
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    Validation of a high-performance liquid chromatographic method with fluorecence detection for the quantification of flurbiprofen in tablets
    Vietnam National University Journal of Science ; 2018
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 34, No. 2 ( 2018-12-24)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 34, No. 2 ( 2018-12-24)
    Abstract: In this study, a high-performance liquid chromatographic method with fluorecence detection was developed for the quantification of flurbiprofen in tablets. A C8 reverse phase column (5 μm, 120 Å, 4.6×150 mm) was used with a mobile phase of acetonitrile : water : glacial acetic acid (65 : 32.5 : 2.5, v/v/v) . The flow rate was 1 ml/min and the column effluent was monitored within 8 minutes. The excitation and emission wavelength were respectively 247 nm and 312 nm. The temperature of flow cell was set at 45˚C and detector sensitivity was 5. The retention time of flurbiprofen was found to be 3.78 minutes. The method was validated under the concentration range of 5 - 100 ng/ml with a tight linear correlation between peak area and sample concentration (R = 0.9999). The proposed method was found to be specific to flurbiprofen, accurate and precise. The percentage recovery was ≤ 100 ± 2%, the relative standard deviation of the repeatability was ≤ 2.08% and the relative standard deviation of the intermediate precision was ≤ 2.96%. The limit of detection and limite of quantification were respectively 0.010 and 0.025 ng/ml.
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4121
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2018
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  • 9
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    Evaluation of Contraindicated Drug-Drug Interactions in Electronic Health Data Insurance at 3 Hospitals in Quang Ninh Province Through Navicat Software
    Vietnam National University Journal of Science ; 2021
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 37, No. 1 ( 2021-03-10)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 37, No. 1 ( 2021-03-10)
    Abstract: Drug-drug interactions is a frequently encountered issue in clinical practice, reduce effectiveness of treatment and lead to dangerous complications for the patients, possibly even death. The purpose of this study is to analyze contraindicated drug interactions when prescribing in some hospitals in Quang Ninh Province. Subjects and methods: List of concentrated contractor drugs applied Quang Ninh province and within the scope of payment of Health Insurance Fund in 2018. The result: the group of researchers developed the list of 112 pairs of the cotraindicated drug-drug interactions to serve as a reference to determine the appearing frequency of contraindicated drug-drug  interactions over 519500 medical records and 1254099 prescriptions at 3 hospitals in Quang Ninh province. Of which, 26 contraindicated drug-drug interactions (0.006%) was found over 297 medical records and 789 prescriptions. 5 pairs with the most appearing frequency are: Amiodarone-Amitriptyline, Amiodarone-Moxifloxacin, Amiodarone-Colchicine, Levodopa -Sulpiride, Amiodarone-Haloperidol. Medical reccords with contraindicated drug-drug interactions were found in 13 different departments or interdisciplinary deparments from all 3 hospitals, of which the highest rates were found in Intensive Care Unit and Emergency Departments (24.2%), Endocrinology Departments (16.2%) and Cardiology Pediatric Departments (10.4%). The average age of patients with contraindicated drug-drug interactions in all 3 hospitals was greater than or equal to 67, most are inpatients. Conclusion: Based on retrospective data on drug prescribing at 3 hospitals in Quang Ninh Province, the study analyzed 26 pairs of common contraindicated drug interactions in clinical practice. Keywords Contraindicated drug-drug interactions, hospitals in Quang Ninh Province, medication review tools. References [1] D.C. Malone, J. Abarca, P.D. Hansten, A.J. Grizzle, E.P. Armstrong, R.C.V Bergen, B.S. Duncan-Edgar, S.L. Solomon, R.B. Lipton, Indentification of Serious Drug-Drug Interactions: Results of the Partnership to Prevent Drug-Drug Interactions, J. Am. Pharm. Assoc. 44 (2004) 142-151. https://doi.org/10.1331/154434504773062591.[2] P. Vonbachl, A. Dubied, S. Kra¨henbu¨hl, J.H.Beer, Evaluation of frequently used drug interaction screening programs, Pharm. World. Sci. 30 (2008) 367-374. https://doi.org/10.1007/s11096-008-9191-x.[3] N.T. Hanh, V.T.P. Thao, H.Q. Tuan, N.X. Bach, N. T. Hai, Developing a list of important drug-drug interactions in the clinical practice in the internal department – Kien An Hospital, Hai Phong City, VNU Journal of Science: Medical and Pharmaceutical Sciences, 35(2) (2019) 54-67. https://doi.org/10.25073/2588-1132/vnumps.4179.[4] L.H. Duong, Developing clinically signification drug-drug interactions at Hop Luc General Hospital (2017), Specialist Pharmacist Graduation thesis – 1st Class, Ha Noi University of Pharmacy (in Vietnamese).[5] L.T. Phuong, Managing clinically signification drug-drug interactions at the National Geriatric Hospital (2018), Pharmacist Graduation thesis, Ha Noi University of Pharmacy (in Vietnamese).[6] T.T. Hoai, Examining drug-drug interactions in the inpatient medical records at the Thai Nguyen Lung Hospital (2017), Specialist Pharmacist Graduation thesis – 1st Class, Ha Noi University of Pharmacy (in Vietnamese).[7] Ministry of Health, Vietnam Regulatory Affairs Society, Medical Publishing House one member Company Limited, Vietnam, 2015 (in Vietnamese).[8] A.P. Heverton, R.L.P Leonardo, M.V Carlos, F.F.C. Maria, Patient’s lack of understanding producing insulin drug-interactions in Southeast Brazilian primary care clinics, Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 3(2) (2019) 1131-1136. https://doi.org/10.1016/j.dsx.2019.01.032    
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4277
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2021
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  • 10
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    Detection of a Novel Mutation on the Gene ESCO2 in a Pediatric Patient with Syndactyly
    Vietnam National University Journal of Science ; 2020
    In:  VNU Journal of Science: Natural Sciences and Technology Vol. 36, No. 3 ( 2020-09-23)
    Details
    In: VNU Journal of Science: Natural Sciences and Technology, Vietnam National University Journal of Science, Vol. 36, No. 3 ( 2020-09-23)
    Abstract: Syndactyly is a congenital disease caused by the limb formation abnormalities during fetal development. In this research, we studied the genetic mutations in a pediatric patient with 3rd  and 4th fingers were fused together, symmetrically using the whole exome sequencing techniques based on Next generation sequencing. The obtained data revealed a novel mutation located in exon 11 of the gene ESCO2: c.1745A 〉 G: p.582K 〉 R. Sequence verification by Sanger sequencing confirmed the existence of this mutation in the patient as heterozygous form. In silico prediction using PredictSNP, PhD-SNP, PROVEAN or Polyphen-2 tools indicated that the mutation was likely to affect the structure and function of Acetyltransferase? (encoded by ESCO2 gene). Further studies will be performed to analyze the effect of this mutations on the intracellular protein network associated with syndactyly.
    Type of Medium: Online Resource
    ISSN: 2588-1140 , 2615-9317
    URL: Article
    DOI: 10.25073/2588-1140/vnunst.4988
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2020
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