Abstract: Objective: Determination of incidence rates and some risk factors for Central Line-Associated Bloodstream Infection (CLABSI) at the Neonatal Center of Vietnam National Children's Hospital. Methods: 416 neonates who were inserted central line from 01/01/2021 to 30/06/2022 were enrolled in our study. CLABSI was defined as CDC 2017 criteria (LCBI3). The primary factors included obstetric history, perinatal history, characteristics of catheters, duration of catheter placement, etc. Result: A total of 672 central lines were placed in 416 infants. Of these, 32 CLABSI cases were identified. Rates of CLABSI was 5.7 infections per 1000 catheter days. Predisposing factors included duration of catheter placement of more than 28 days (OR = 2.9; 95% CI: 1.03 – 8), abdominal condition (OR = 5.3; 95% CI: 1.5 – 18.6) and steroid used (OR 5.3; CI 1.98 – 14.3). Conclusion: The “CLABSI prevention package” was effective in reducing the CLABSI rate and could be applied in other hospitals.

Abstract: Panax bipinnatifidus Seem. is a precious medicinal plant belonging to the Araliaceae family. This study qualitatively analyzed saponins of the stem, leaf and rhizome of P. bipinnatifidus by HPLC. Subsequently, by using chromatographic techniques, a major saponin from the leaf of P.bipinnatifidius Seem. was isolated. On the basis of NMR and MS spectroscopic data as well as comparison with those reported in the literature, the isolated saponin’s structure was identified as stipuleanoside R2. To the best our knowledge, this is the first report of saponin from the aerial part of P. bipinnatifidius Seem. Keywords Panax bipinnatifidus, Araliaceae, Stipuleanosid R2, HPLC.. [1] Nguyễn Văn Tập, Các loài thuộc chi Panax L. ở Việt Nam, Tạp chí Dược liệu. 10(3) (2005) 71-76. [2] Nguyễn Văn Tập, Phạm Thanh Huyền, Kết quả nghiên cứu về phân bố, sinh thái sâm vũ diệp và Tam thất hoang ở Việt Nam, Tạp chí Dược liệu. 11(5) (2006) 177-180. [3] Nguyen Huu Tung, Tran Hong Quang, Nguyen Thị Thanh Ngan, Chau Van Minh, Bui Kim Anh, Pham Quoc Long, Nguyen Manh Cuong, Young Ho Kim, Oleanolic triterpenesaponins from the roots of Panax bipinnatifidus, Chem Pharm Bull (Tokyo). 59(11) (2011) 1417-1420. [4] Đỗ Văn Hào, Nguyễn Thị Huệ, Nguyễn Thị Thu Thủy, Đặng Thị Ngần, Đào Thị Hồng Bích, Nguyễn Thị Hoàng Anh, Dương Thị Ly Hương, Nguyễn Hữu Tùng, Thành phần hóa học của phân đoạn ethyl acetat từ rễ cây sâm vũ diệp (Panax bipinnatifidus Seem.) thu hái ở Sa Pa, Lào Cai, Tạp chí Khoa học ĐHQGHN - Khoa học Y Dược. 33(2) (2017) 50-55. [5] Nguyễn Thị Thu Thủy, Nguyễn Thị Huệ, Đặng Thị Thùy, Nguyễn Thị Hoàng Anh, Dương Thị Phượng, Phạm Thị Tuyết Nhung, Hà Vân Oanh, Dương Thị Ly Hương, Nguyễn Hữu Tùng, Thành phần saponin của thân rễ sâm vũ diệp thu hái ở Sa Pa, Lào Cai, Tạp chí Dược liệu. 23(2) (2018) 82-88.[6] Wen-zhi Yang, Ying Hu, Wan-ying Wu, Min Ye, De-an Guo, Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity, Phytochemistry. 106 (2014) 7-14. [7] Shashi B. Mahato, Asish P. Kundu, 13C NMR spectra of pentacyclic triterpenoids - a complication and some salient features, Phytochemistry. 37 (1994) 1517-1575. [8] Pawan K. Agrawal, NMR spectroscopy in the structural elucidation of oligossacharides and glycosides, Phytochemistry. 31 (1992) 1307-1330. [9] Chun Liang, Yan Ding, Huu Tung Nguyen, Jeong-Ah Kim, Hye-Jin Boo, Hee-Kyoung Kang, Mahn Cuong Nguyen, Young Ho Kim, Oleanane –type triterpenoids from Panax stipuleannatus and their anticancer activities, Bioorg Med Chem Lett. 20 (2010) 7110-7115.  

Abstract: Abstract: We conducted this research to determine the NAT2 gene-phenotype characteristics and pharmacokinetics (PK) parameters of isoniazid among patients with non-MDR pulmonary tuberculosis. Data were collected from 132 patients diagnosed with newly acquired or relapsed tuberculosis and treated at 03 hospitals: Hanoi Lung Hospital, Central Lung Hospital, and National K74 Hospital. PK samples were collected one day from the 10th – 14th day after commencing treatment. The average age of the recruited patients was 45.43 ± 15.76 years; the majority were male (74.24%). The slow and medium acetylator types, as indicated by NAT2 phenotypes, were the two major types (37.88% and 35.6%, respectively). 61.12% of the patients had their Bayesian isoniazid-acetyl isoniazid population PK modeling - determined Cmax value within the therapeutic range of 3 – 6 µg/mL. Acelytator type showed a statistically significant correlation with Cmax. Keywords: Isoniazid, pharmacokinetics, Cmax, tuberculosis.

Abstract: Morphological and microscopical characteristics of “Co ruoi la bac” collected in Nam Dinh province were studied. Results have identified the scientific name of the plant as Murdannia bracteata (family Commelinaceae). Besides, the microscopical characteristics and powder microscopy of leaf and stem of M. bracteata species were established. Specifically, the plant’s leaf and stem are characterized by pale violet corolla, oval bracts and needle shape calcium oxalate crystals converging or single in the soft tissue of the leaf; the herbal powder has twisted vascular grafts, unicellular hairs,… Keywords: Murdannia bracteata, M. bracteata, Murdannia bracteata (C.B.Clarke) J.K.Morton ex D.Y.Hong, Commelinaceae, morphological characteristics, microscopical characteristic References [1] M. D. O. Pellegrini, R. B. Faden, R. F. D. Almeida, Taxonomic Revision of Neotropical Murdannia Royle (Commelinaceae), PhytoKeys, Vol. 74, 2016, pp. 35-78, https://doi.org/10.3897/phytokeys.74.9835.[2] R. B. Faden, K. E. Inman, Leaf Anatomy of The African Genera of Commelinaceae: Anthericopsis and Murdannia, The Biodiversity of African Plants, 1996, pp. 464-471, https://doi.org/10.1007/978-94-009-0285-558.[3] M. C. Naik, B. R. P. Rao, A New Species of Dewflower Murdannia Sanjappae (Commelinaceae) from Andaman Islands, India, Journal of Threatened Taxa, Vol. 9, No. 11, 2017, pp. 10909-10913, http://doi.org/10.11609/jott.3341.9.11.10909-10913.[4] V. V. Chi, Dictionary of Medicinal Plants in Vietnam, Medical Publishing House, Hanoi, 2012 (in Vietnamese).[5] P. H. Ho, An Illustrated Flora of Vietnam, Youth Publishing House, Ho Chi Minh City, 2003 (in Vietnamese).[6] M. Betti, A. Minelli, B. Canonico, P. Castaldo, S. Magi, M. Aisa, F. Galli, Antiproliferative Effects of Tocopherols (Vitamin E) on Murine Glioma C6 Cells: Homologue-specific Control of PKC/ERK and Cyclin Signaling, Free Radical Biology and Medicine, Vol. 41, No. 3, 2006,pp. 464-472, http://doi.org/10.1016/j.freeradbiomed.2006.04.012.[7] N. N. Thin, Plant Research Methods, Education Publishing House, Hanoi, 2006 (in Vietnamese).[8] V. D. Loi, L. T. T. Huong, Texbook: Practical Botany - Pharmacognosy - Traditional Medicine, Hanoi National University Publishing House, Hanoi, 2017 (in Vietnamese).

Abstract: Abstract: This study examines the effect of substituted concentration on the structure and magnetic properties of Y3Fe5-xInxO12 (x = 0.1 ÷ 0.7) powder samples prepared using the sol-gel method. The morphological properties of the samples were analysed using XRD, SEM. The single phase of garnet was obtained in x = 0.1 ÷ 0.6 samples. The lattice parameters of the samples exhibit a linear increase with the increasing In3+ content, which can be explained by a substitution of In3+ ions for Fe3+ ions, considering the larger ionic radius of In3+ compared with that of Fe3+. Crystallite sizes were determined via the XRD data which are of 38 – 49 nm while the particle sizes were estimated from SEM images to be in range of 50 - 100 nm. Magnetization and Curie temperature of the single phase samples were studied by magnetization curves in fields up to 10 kOe and in the temperature range from 80 K to 560K. With the increase of In3+, the magnetization gradually increases while the Curie temperature decreases due to the occupation of In atoms at the a sites and the reduction of intersublattice interaction, respectively. Keywords: Yttrium iron garnet, Indium substitution, cation distribution, magnetization, Curie temperature. References[1] R. L. Streever, Anisotropic exchange in ErIG, Journal of Magnetism and Magnetic Materials 278 (1-2) (2014) 223-230.[2] N.I. Tsidaeva, The magnetic and magnetooptical properties of Y-substituted erbium iron garnet single crystals, Journal of Alloys and Compounds 374 (1-2) (2004) 160-164.[3] Y.Nakata, T. Okada, M. Maeda, S. Higuchi and K. Ueda, Effect of oxidation dynamics on the film characteristics of Ce:YIG thin films deposited by pulsed laser deposition, Optics and Lasers in Engineering 44 (2) 2006, 147-154.[4] M. Laulajainen, P. Paturi, J. Raittila, H. Huhtinen, A.B. Abrahamsen, N.H. Andersen and R. Laiho, BixY3-xFe5O12 thin film prepared by laser ablation for magneto-optical imaging of superconducting thin films, Journal of Magnetism and Magnetic Materials 279 (2-3) (2004) 218-223.[5] A.A. Lagutin, G.E. Fedorov, J. Vanacken and D. Herlach, Magnetic properties of dysprosium Yttrium ferrite garnet in pulsed magnetic fields at low temperatures, Journal of Magnetism and Mmagnetic Materials 195 (1999) 97-106.[6] S.A. Nikotov, Nonlinearity: Magneto-optic microwave interactions. Towards new devices, Journal of Magnetism and Magnetic Materials (196-197) (1999) 400-403.[7] C.S. Tsai, Wideband tunable microwave devices using, European Ceramic Society 23 (14) (2003) 2721-2726.[8] A. Sztaniszlav, M. Farkas-Jahnke, M. Balla, Kinetics of garnet formation in In3+ substituted systems, Journal of Magnetism and Magnetic Materials 215-216 (2000) 188-193.[9] R.G. Vidhate, V.D. Murumkas, R.G. Dorik, N.M. Makne, S.R. Nimbore, K.M. Jadhav, Magnetic properties of In Substituted ytrium iron garnet (YIG), Rev. Res. 1(10) (2012) 1-4.[10] G. Cuijing, Z. Wei, J. Rongjin, Z. Yanwei, Effect of In3+ substitution on the structure and magnetic properties of multi-doped YIG ferrites with low saturation magnetizations, Journal of Magnetism and Magnetic Materials 323, (2011) 611-615.[11] Vu Thi Hoai Huong, Dao Thi Thuy Nguyet, To Thanh Loan, Luong Ngoc Anh, Nguyen Phuc Duong, Than Duc Hien, Structural and magnetic properties of Y3-2xCa2xFe5-xVxO12 nanoparticles prepared by sol-gel method, Proceeding of the 3rd International Conference on Advanced Materials and Nanotechnology (2016) 219-223.[12] Imaddin A. Al-Omari, Ralph Skomski, David J. Sellmyer, Magnetic properties of Y3-2xCa2xFe5-xVxO12 garnets, Advances in Materials Physics and Chemistry 2 (2012) 116-120.[13] Rodziah Nazlan, Mansorhashim, Idza Riati Ibrahim, Fadzidah Mohd Idris, Wan Norailiana Wan Ab Rahman, Nor Hapishah Abdullah, Ismayadi Ismail, Saikannu Kanagesan, Zulkifly Abbas, Rabaah Syahidah Azis, Influence of Indium substitution and microstructure changes on the magnetic properties evolution of Y3Fe5-xInxO12 (x = 0.0 – 0.4), Journal of Material Science: Materials in Electronics 26, 6 (2015) 3596-3609.[14] M. Niyaifar, A. Beitollahi, N. Shiri, M. Mozaffari, J. Amighian, Effect of indium addition on the structure and magnetic properties of YIG, Journal of Magnetism and Magnetic Materials 322 (2010) 777 – 779.[15] J. Richard Cunningham Jr and Elmer E. Anderson, Effect of indium substitution in Yttrium iron garnet. High permeability garnets, Journal of Applied Physics 32, (1961) S388.[16] L. Vegard Dr. Phil, LV. Results of crystal analysis. –III, Philosophical magazine Series 6, 32: 191, 505 – 518.[17] Ronald W. Armstrong, Crystal dislocations, Crystals 6, 1 (2016) 9.[18] Gerald F. Dionne, Molecular field coefficients of substituted yttrium iron garnets, Journal of Applied Physics. 41 (1970) 4874.[19] M.A. Gilleo, Ferromagnetic insulators: Garnets, in: E.P. Wohlfarth (Ed.), Handbook of Magnetic Materials, Volume 2, North-Holland Publishing Company, 1980, 1-54.[20] Z. Azadi Motlagh, M. Mozaffari, J. Smighian, Preparation of nano-sized Al-substituted yttrium iron garnets by the mechanochemical method and investigation of their magnetic properties, Journal of Magnetism and Magnetic Materials 321 (2009) 1980-1984.[21] P. Belov and I.S. Lyubutin, Effective magnetic fields at tin nuclei in substituted iron garnets CaxY3-x SnxFe5-x O12, Soviet Physics JETP 22 (3) (1966) 518 – 520.

Abstract: Microplastics (particles with a size of less than 5 mm) are a rising environmental problem. Microplastics can disseminate in the air and accumulate in sediments as well as in microorganisms and humans, due to their small size. Sediment is considered to be the major repository of microplastics, particularly those of the PE type. Microplastics in massive amounts accumulated in sediments, perhaps as a result of point sources or diffuse contamination. Microplastic contamination can spread from industrial production facilities, urban areas, agricultural areas, or the air. The current study was carried out to explore the occurrence of MPs in sediments at discharge sources by evaluating 27 sediment samples taken from 9 distinct waste sources from industrial activity locations to determine the amount of microplastic contamination in sediments at discharge sources. Microplastics with relatively high density were found in all sediment samples in this research, ranging from 2,900 to 238,200 particles/kg dw. The most prevalent microplastics detected in sediment samples at these sites were fibers and fragments, accounting for 59-94% and 6-41%, respectively. Fiber microplastics ranged in size from 1000 to 9,000 µm, whereas fragment microplastics ranged from 200,000 to 2,100,000 µm2. Microplastics with 〈 1000 µm and 1000-2000 µm sizes accounted for a significant portion of the total, reaching 21.05-37.84% and 39.74-61.17%, respectively. The hue of microplastic particles in sediment samples obtained was highly varied.

Abstract: Panax bipinnatifidius Seem. is one of the highly valuable and most used in Vietnam. By using the chromatographic techniques, we have purified three compounds from the ethyl acetate fraction of the root of P.bipinnatifidius Seem.Three compounds were identified as β-sitosterol (1), oleanolic acid (2), and daucosterol (3), respectively, on the basis of analysis of NMR and MR spectrum data. This is the first publication on the isolation of these compounds from P. bipinnatifidius Seem. in Vietnam. nnatifidius Seem. in Vietnam

Abstract: Morphological and microscopical characteristics of “Chua me dat hoa vang” collected in Ha Tinh province were studied. Results have identified the scientific name of the plant as Oxalis corniculata L. (family Oxalidaceae). Besides, the morphological characteristics and powder microscopy of leaf and stem of Oxalis corniculata L. species were established. Morphological characteristics of leaf and stem are pale yellow corolla, slightly pointed bracts and cube calcium oxalate crystals scattered in the soft tissue of the leaf. characteristics of herbal powder are twisted vascular grafts, hairs unicellular. Keywords Oxalis corniculata, Oxalis corniculata L., Oxalis, Oxalidaceae, morphological characteristics, microscopical characteristics. References [1] D.H. Bich, D.Q. Chung, B.X. Chuong, N.T. Dong, D.T. Dam, P.V. Hien, V.N. Lo, P.D. Mai, P.K. Man, D.T. Nhu, N. Tap, T. Toan, Medicinal plants and animals in Vietnam, Volume I, Science and Technology Publishing House, Hanoi, 2004. (in Vietnamese)[2] M. Ibrahim, I. Hussain, M. Imran, N. Hussain, A. Hussain, T. Mahboob, Corniculatin A, a new flavonoidal glucoside from Oxalis corniculata, Revista Brasileira de Farmacognosia 23(4) (2013) 630-634. https://doi.org/10.1590/S0102- https://doi.org/10.1590/S0102695X2013005000059.[3] K.C. Oberlander, E. Emshwiller, D.U. Bellstedt, L.L. Dreyer, A model of bulb evolution in the eudicot genus Oxalis (Oxalidaceae), Molecular Phylogenetics and Evolution 51(1) (2009) 54–63. https://doi.org/10.1016/j.ympev.2008.11.022.[4] J. Zietsman, L.L. Dreyer, B. Jansen, V. Vuuren, Genetic differentiation in Oxalis (Oxalidaceae): A tale of rarity and abundance in the Cape Floristic Region, South African Journal of Botany, 75(1) (2009) 27–33. https://doi.org/10.1016/j.sajb.2008.06.003[5] L.D. Bich, Good folk remedies, Ethnic Culture Publishing House, Hanoi, 2000 (in Vietnamese).[6] L.D. Bich, T.V. On, Botany, Medical Publishing House, Hanoi, 2007 (in Vietnamese).[7] D.T. Loi, Vietnamese medicinal plants and herbs, Medical Publishing House, Hanoi, 2005 (in Vietnamese).[8] N.V. Than, Laboratory of Medicinal Materials by microscopic method, Science and Technology Publishing House, Hanoi, 2003 (in Vietnamese).      

Abstract: From the past to the present, human has mostly accumulated and passed on knowledge through the source of documents such as books. However, to day the "lazy reading" situation is popular among young people, which is one of the causes of passivity in research and learning of students. Teaching children to read Vietnamese since they were still in preschool level to help shape and develop the ability to read children is still a matter of concern. It is being studied and considered to be applied in teaching practice and academic research. With the goal of sharing the benefits of teaching preschool children to read Vietnamese language, the paper presents the research results on children's reading ability, the process of teaching children to read Vietnamese early in each period. The article results can be used as a reference for the study, for parents who want to teach their children Vietnamese literacy.

Abstract: This study describes clinical, paraclinical characteristics and treatment response in children with nephritis class II-IV caused by systemic lupus erythematosus and validates SLEDAI for the evaluation of disease activity and the appropriate treatment strategy. A cross-sectional descriptive study was carried out on 40 children, 37 girls (92%) and 3 boys (8%), with an average age of 11.7 years with lupus nephritis class III- IV in Vietnam National Children’s Hospital in 2019. The study results show that the average score of SLEDAI in the children with pericardial and pleural effusions was 20.94 ± 4.09; high blood pressure, 20.89 ± 4.23; and gross hematuria, 20.29 ± 5.03, which were higher than those in children without these manifestations with p 〈 0.05. The most common kidney manifestations were nephrotic-range nephritis with renal failure (40%) and Glomerulonephritis (35%), corresponding to an average SLEDAI score of 24.25 ± 5.52 and 24.33 ± 3.2, respectively (p = 0.001). SLEDAI had an inverse correlation with the C3 complement value (r -0.315, p 〈 0.05). The average SLEDAI score decreased gradually from 18.75 ± 4.22 to 3.38 ± 3.95 points (p 〈 0.001) after 12 months of treatment.  The study concludes that SLEDAI score was higher in patients with pleural and/or pericardial effusions, hypertension and gross hematuria, nephrotic-range nephritis with kidney failure or glomerulonephritis. SLEDAI score corresponded with the C3 complement value and the average SLEDAI score decreased gradually with treatment. Keywords: Lupus Nephritis class III- IV, SLEDAI. References [1] George Bertsias, Ricard Cervera và Dimitrios T Boumpas, Systemic Lupus Erythematosus: Pathogenesis and Clinical Features 〈 sample chapter 20_mod 17_Systemic Lupus nephritis 2012.pdf 〉 (2012), EULAR Textbook on Rheumatic Diseases, EULAR, 476-505.[2] D.M. Levy and S. Kamphuis, Systemic lupus erythematosus in children and adolescents. Pediatr Clin North Am59(2) (2012)345-64.[3] Thai Thien Nam, 2018, Lupus in National Children,s Hospital, [4] C.Bombardier, M.B. Hurwitz et al, Derivation of the SLEDAI: A disease activity index for lupus patients. The committee on prognosis studies in SLE, Arthritis Rheum 35(6) (1992) 630-640.[5] R. Shamim, S. Farman, S. Batool et al, Association of systemic lupus erythematosus disease activity index score with clinical and laboratory parameters in pediatric onset systemic lupus erythematosus. Pak J Med Sci. 36(3) (2020) 467-472.[6] Le Thuy Hang, Assesment of SLEDAI score and panthology in children with lupus nephritis, 2016, Pediatrician thesis, Hanoi Medical University.[7] S.K.S.M. Nazri, K.K. Wong and W.Z.W.A. Hamid, Pediatric systemic lupus erythematosus. Retrospective analysis of clinico-laboratory parameters and their association with Systemic Lupus Erythematosus Disease Activity Index score, Saudi Med J. 39(6) (2018) 627-631. [8] Nguyen Thuy Duong, clinical, paraclinical and pathology characteristics in children with nephritis caused by systemic lupus erythematosus, 2011, Master thesis, Hanoi Medical University.[9] S.N. Wong, W.K. Chan, J.Hui et al, Membranous lupus nephritis in Chinese children--a case series and review of the literature. Pediatr Nephrol, 24(10)(2009) 1989-1996.[10] N.T.N. Dung, H.T. Loan, S. Nielsen et al, Juvenile systemic lupus erythematosus onset patterns in Vietnamese children: a descriptive study of 45 children. Pediatric Rheumatology Online Journal, 10 (2010) 38-48.[11] T. Pusongchai, J. Jungthirapanich, S. Khositseth, Pediatric Systemic Lupus Erythematosus in Thammasat University Hospital, J Med Assoc Thai. 93(12) (2010) 283-290.