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  • Universitas Negeri Gorontalo  (4)
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  • Universitas Negeri Gorontalo  (4)
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  • 1
    Online Resource
    Online Resource
    Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar
    Universitas Negeri Gorontalo ; 2019
    In:  Journal Syifa Sciences and Clinical Research Vol. 2, No. 1 ( 2019-11-13), p. 1-10
    Details
    In: Journal Syifa Sciences and Clinical Research, Universitas Negeri Gorontalo, Vol. 2, No. 1 ( 2019-11-13), p. 1-10
    Abstract: Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.
    Type of Medium: Online Resource
    ISSN: 2656-9612 , 2656-8187
    URL: Article
    DOI: 10.37311/jsscr.v2i1.2704
    Language: Unknown
    Publisher: Universitas Negeri Gorontalo
    Publication Date: 2019
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Uji Toksisitas Akut Ekstrak Air Dan Ekstrak Etanol Daun Kacapiring (Gardenia jasminoides Ellis) Terhadap Larva Artemia Salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT)
    Universitas Negeri Gorontalo ; 2021
    In:  Indonesian Journal of Pharmaceutical Education Vol. 1, No. 2 ( 2021-05-30), p. 98-106
    Details
    In: Indonesian Journal of Pharmaceutical Education, Universitas Negeri Gorontalo, Vol. 1, No. 2 ( 2021-05-30), p. 98-106
    Abstract: A toxicity test is a test to detect the toxic effect of a substance on a biological system and to obtain typical dose-response data from the test preparation. This study aims to determine the content of secondary metabolites from the aqueous extract and ethanolic extract of gardenia leaves, characterization of gardenia leaf extract, and acute toxicity using the BSLT method against Artemia salina Leach shrimp larvae.Phytochemical screening tests were carried out by the color change method which included the alkaloid test, flavonoid test, tannin test, saponin test, and terpenoid test. Extract characterization tests include determination of water-soluble extract, determination of ethanol-soluble extract, determination of water content, and determination of ash content. Acute toxicity test using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae.The results of the phytochemical screening test for the aqueous extract of gardenia leaves showed positive results on saponins, while the phytochemical screening tests on ethanol extracts showed positive results on alkaloids, flavonoids, saponins, tannins, and terpenoids. The results of the characterization test on the aqueous extract of gardenia leaves were that the ethanol-soluble extract content was 20.19%, the water-soluble extract content was 23.17%, the water content was 99.13% and the ash content was 0.29%. Meanwhile, in the ethanolic extract of gardenia leaves, the ethanol-soluble extract content was 60.80%, the water-soluble extract content was 57.14%, the water content was 7.87% and the ash content was 3.22%. The results show that gardenia leaves are not toxic with the LC50 value of the water extract of the gardenia leaves is 1399.64 g/mL and the LC50 value of the ethanolic extract of the gardenia leaves is 1080.96 so that it can be used as traditional medicine. 
    Type of Medium: Online Resource
    ISSN: 2775-3670
    URL: Issue
    URL: Article
    DOI: 10.37311/ijpe.v1i2
    DOI: 10.37311/ijpe.v1i2.11462
    Language: Unknown
    Publisher: Universitas Negeri Gorontalo
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Histopatologi Organ Pankreas Tikus DM tipe 2 yang diberi Ekstrak Etanol Daun Gedi Merah (Abelmoscus manihot L. Medik)
    Universitas Negeri Gorontalo ; 2022
    In:  Journal Syifa Sciences and Clinical Research Vol. 4, No. 1 ( 2022-02-17)
    Details
    In: Journal Syifa Sciences and Clinical Research, Universitas Negeri Gorontalo, Vol. 4, No. 1 ( 2022-02-17)
    Abstract: Gedi Merah leaf (Abelmoschus manihot L.Medik) is a tropical plant used by the community as a traditional medicine to reduce cholesterol, hypertension, and antidiabetic levels. Diabetes mellitus is a disorder of carbohydrate, protein, and fat metabolism due to a lack of the hormone insulin so that glucose in the blood increases which is characterized by changes in the histopathological structure of the pancreatic islets of Langerhans. The purpose of this study was to see the histopathological description of the pancreas in male white rats (Rattus norvegicus) Wistar strain model of type II diabetes mellitus by administering ethanol extract of red gedi leaves (Abelmoschus manihot L.Medik). Modeling of diabetes mellitus in experimental animals was carried out by administering a high-fat diet and intraperitoneal induction of streptozotocin 30 mg/kg. After modeling, male rats were grouped into 6 treatment groups, namely a normal control group, a positive control group, a negative control group, and a group that was given the ethanol extract of red gedi leaves at a dose of 75 mg/kg BW, 150 mg/kg BW 300 mg/kg BW. The results of the histopathological examination of the pancreas and the number of endocrine cells showed that the ethanolic extract of red gedi leaves (Abelmoschus manihot L.Medik) was effective in repairing pancreatic cells and regenerating endocrine cells in the islets of langerhans.
    Type of Medium: Online Resource
    ISSN: 2656-9612 , 2656-8187
    URL: Issue
    URL: Article
    DOI: 10.37311/jsscr.v4i1
    DOI: 10.37311/jsscr.v4i1.13566
    Language: Unknown
    Publisher: Universitas Negeri Gorontalo
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    FRAKSI EKSTRAK ETANOL BUAH PARE (Mommordica charantia L.) SEBAGAI ANTIINFLAMASI TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α)
    Universitas Negeri Gorontalo ; 2022
    In:  Journal Syifa Sciences and Clinical Research Vol. 4, No. 1 ( 2022-08-11)
    Details
    In: Journal Syifa Sciences and Clinical Research, Universitas Negeri Gorontalo, Vol. 4, No. 1 ( 2022-08-11)
    Abstract: Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.
    Type of Medium: Online Resource
    ISSN: 2656-9612 , 2656-8187
    URL: Issue
    URL: Article
    DOI: 10.37311/jsscr.v4i1
    DOI: 10.37311/jsscr.v4i1.13484
    Language: Unknown
    Publisher: Universitas Negeri Gorontalo
    Publication Date: 2022
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