Note: Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Plant-Derived Anticancer Compounds Used in Cancer Therapies -- Alexander Chota1, Blassan P. George1 and Heidi Abrahamse1,* -- INTRODUCTION -- Current Cancer Treatment Options and Their Limitations -- Origin/History of Plant-derived Agents in Cancer Therapies -- Ayurvedic System of Medicine in Cancer Therapies -- Plant Derived Anticancer Compounds and their Clinical Uses -- The General Classification of Major Plant-derived Anticancer Compounds -- Alkaloids -- Flavonoids -- Brassinosteroids -- Terpenoids -- Structures of Major Anticancer Compounds of Plant Origin -- Common Anticancer Drugs of Plant Origin in Clinical Practice -- General Mechanism of Action of Plant-derived Anticancer Compounds -- Importance and Advantages of Anticancer Compounds of Plant Origin -- CONCLUSION AND FUTURE PERSPECTIVES -- ACRONYMS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Pradimicin and Benanomicin Antibiotics: From Antifungal Polyketide Natural Products to Antiviral Agents with a Unique Carbohydrate-Binding Mode of Action -- Rocío Abín1, Visitación López-Miranda2,3, Ana San-Félix1 and Ernesto Quesada1,3,* -- INTRODUCTION -- DISCOVERY, STRUCTURAL CHARACTERISATION AND CHEMICAL MODIFICATIONS -- BIOLOGICAL ACTIVITIES -- Antifungal Activity -- Antiviral Activity -- Other Activities: Antibacterial, Antitumoral -- MECHANISM OF ACTION OF BPAS -- A Unique Mechanism of Action: Calcium-Dependent Mannose Binding -- Carbohydrate-binding Agents (CBAs): Glycans of HIV as Therapeutic Targets -- Apoptosis -- Biosynthesis of BPAs: Tailoring Polyketides -- Total Synthesis of BPAs -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES. , The Chemical Compositions of Bixa orellana and their Pharmacological Activities -- Carlos A. Méndez-Cuesta1, Fernando Rodríguez-Ramos1, Cuauhtémoc Pérez-González1, Julia Pérez-Ramos1 and Salud Pérez-Gutiérrez1,* -- INTRODUCTION -- USE IN TRADITIONAL MEDICINE -- PHYTOCHEMISTRY -- ANTIMICROBIAL ACTIVITY -- ANTIPARASITIC ACTIVITY -- ANTI-INFLAMMATORY EFFECTS -- HYPOGLYCEMIC EFFECTS -- METABOLIC SYNDROME -- CYTOTOXIC ACTIVITY -- ANTIOXIDANT ACTIVITY -- HEPATOPROTECTIVE ACTIVITY -- BRONCHODILATOR EFFECTS -- DIURETIC EFFECTS -- DISCUSSION AND CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- LIST OF ABBREVIATIONS -- REFERENCES -- Overview of Phytochemistry and Pharmacology of Nilakanthi (Ajuga bracteosa Wall. ex Benth.) -- Apurba Gohain1, Debanga Sourav Saikia1, Sangita Baruah2, Ashoke Kumar Das3 and Ajay Sharma4,* -- INTRODUCTION -- BOTANICAL DESCRIPTION -- MORPHOLOGY -- TRADITIONAL USES -- MODERN USES -- PROBABLE METHODS OF CULTIVATION -- STATUS AND METHOD OF CONSERVATION -- PHYTOCHEMICAL COMPOSITION -- PHARMACOLOGICAL ACTIVITY -- ANTICANCER -- ANTI-INFLAMMATORY -- ANTI-DIABETIC -- ANTIANALGESICS -- ANTIOXIDANT -- OTHER ACTIVITIES -- GREEN SYNTHESIS OF METAL NANOPARTICLES -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Tetracyclic Benzocarbazoles and Derivatives: Synthesis and Applications -- Francisco Vilaça Gaspar1, Joseane Alves Mendes2, Paulo Roberto Ribeiro Costa1, Miguel Yus2, Francisco Foubelo1 and Camilla Djenne Buarque3,* -- INTRODUCTION -- Early Methodologies and Modern [3, 3]-sigmatropic Rearrangement -- Disconnections Using Aniline and Tetralones or Indenones Derivatives -- Disconnections Using o-iodo-N-(arylsulfonyl)anilines and Dihydronaphtalenes or Indenes Derivatives -- Disconnections Employing Indol Derivatives. , Asymmetric Synthesis Employing Chiral N-tert-butanesulfinyl Imines -- Disconnections Employing 2H-chromen-2-ones and Analogs -- Aza-Coumestans and Derivatives -- Cross-coupling Reactions -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Chalcones as Anti-inflammatory, Anti-diabetic, and Anti-depressant Agents -- Begum Evranos Aksoz1,* -- INTRODUCTION -- ANTI-INFLAMMATORY CHALCONES -- Anti-inflammatory Targets for Chalcones -- Heme Oxygenase-1 -- Nuclear Factor-κB and Histone Deacetylases -- Kinases and Activator Protein-1 -- Toll-like Receptor 4 and Myeloid Differentiation 2 Accessory Molecule -- Cyclooxygenase and 5-Lipoxygenase -- Nitric Oxide -- Tumour Necrosis Factor-Alpha, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 -- Monocyte Chemoattractant Protein-1 -- Interleukins -- Natural Anti-inflammatory Chalcones -- Synthesized Anti-inflammatory Chalcones -- ANTIDIABETIC CHALCONES -- Antidiabetic Targets for Chalcones -- Sodium Glucose Cotransporter 2 -- Glucose Transporter Type 4 -- Adenosine Monophosphate Activated Protein Kinase -- Peroxisome Proliferator-Activated Receptor Gamma -- α-Glucosidase -- Dipeptidyl Peptidase-IV -- Protein Tyrosine Phosphatase 1B -- Aldose Reductase -- Natural Antidiabetic Chalcones -- Synthesized Antidiabetic Chalcones -- ANTIDEPRESSANT CHALCONES -- Antidepressant Targets for Chalcones -- 5-Hydroxytryptamine -- Norepinephrine (NE) -- Monoamine Oxidase -- Natural Antidepressant Chalcones -- Synthesized Antidepressant Chalcones -- CRITICAL ASSESSMENT AND DISCUSSION -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Bioactive Steroids from Marine Organisms -- Marina P. Savić1,*, Marija N. Sakač1 and Jovana. J. Ajduković1 -- INTRODUCTION -- BIOACTIVE STEROIDS FROM MARINE SPONGES. , A-Norsteroids -- Steroid Alkaloids -- Pregnane Steroids -- Oxygenated Steroids -- Dioles and Trioles -- Polyhydroxylated Steroids -- Epoxysterols -- Epidioxysterols -- Steroid Sulfates -- Steroid Monosulfates -- Steroid Polysulfates -- Sulfated Steroid Dimers -- Sulfated Amino-acid Conjugates -- Secosteroids -- Polyacetylated Sterols -- Keto Steroids -- Steroid Esters -- Steroid Glycosides -- Methylene steroids -- 4-Methylene Sterols with Rearranged 6/6/5/7 Ring System -- 4-Methylene Secosterols -- Sterols with a Cyclopropane Ring at C-25 and C-26 -- Others -- Phenanthrene Steroid Derivatives -- Steroid Derivatives with Bicyclo [4.3.1] A/B Ring -- BIOACTIVE STEROIDS FROM MARINE MACROALGAE -- BIOACTIVE STEROIDS FROM MARINE CUCUMBERS -- Triterpene Δ7 Glycosides -- Triterpene Δ9(11) Glycosides -- Triterpene Δ8 and Spyro Glycosides -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Subject Index -- Back Cover.