In:
Clinical and Molecular Hepatology, The Korean Association for the Study of the Liver, Vol. 26, No. 4 ( 2020-10-01), p. 562-576
Abstract:
Background/Aims: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. 〈 br/ 〉 Methods: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed. 〈 br/ 〉 Results: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, 〈 i 〉 P 〈 /i 〉 =0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died ( 〈 i 〉 P 〈 /i 〉 〈 0.05). The overall survival rate was significantly lower in patients with liver cirrhosis than in those without liver cirrhosis (log-rank test, 〈 i 〉 P 〈 /i 〉 =0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval [CI], 1.20–17.02; 〈 i 〉 P 〈 /i 〉 =0.026) and death (hazard ratio, 2.86; 95% CI, 1.04–9.30; 〈 i 〉 P 〈 /i 〉 =0.042) in COVID-19 patients. 〈 br/ 〉 Conclusions: This study suggests liver cirrhosis is a significant risk factor for COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients.
Type of Medium:
Online Resource
ISSN:
2287-2728
,
2287-285X
DOI:
10.3350/cmh.2020.0126
Language:
English
Publisher:
The Korean Association for the Study of the Liver
Publication Date:
2020
detail.hit.zdb_id:
2672531-9
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