In:
Journal of the Endocrine Society, The Endocrine Society
Abstract:
Patients with acromegaly are characterized by the chronic exposure to high GH and IGF-1 levels, known for their anabolic effect on skeletal muscle. Therefore, an increased skeletal muscle mass could be hypothesized in these subjects. Herein, we have performed a systematic revision of published evidences regarding skeletal muscle mass, quality, and performance in subjects with acromegaly. Evidence Acquisition A systematic review of the literature on PUBMED database up to September 1st 2023 has been conducted with the following query: acromegaly AND (“muscle mass” OR “skeletal muscle”). We excluded studies that did not compare different disease states or used non-radiological methods for the skeletal muscle analyses, except for bioelectrical impedance analysis. Evidence Synthesis N = 15 studies meet inclusion criteria. A total of 360 patients were evaluated for skeletal muscle mass, 122 for muscle fatty atrophy, and 192 for muscle performance. No clear evidence of increased skeletal muscle mass in patients with active disease compared to controlled or healthy subjects emerged. As for skeletal muscle quality, we observed a trend towards higher fatty infiltration among patients with acromegaly compared to healthy subjects. Likewise, patients with active disease showed consistent worse physical performances compared to controlled or healthy subjects. Conclusions Skeletal muscle in acromegaly has lower quality and performance compared to healthy subjects. The small number of published studies and multiple confounding factors (e.g. use of different radiological techniques) contributed to mixed results, especially regarding skeletal muscle mass. Well-designed prospective studies are needed to investigate skeletal muscle mass in patients with acromegaly.
Type of Medium:
Online Resource
ISSN:
2472-1972
DOI:
10.1210/jendso/bvae032
Language:
English
Publisher:
The Endocrine Society
Publication Date:
2024
detail.hit.zdb_id:
2881023-5
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