In:
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society, Vol. 94, No. 5 ( 2009-05-01), p. 1713-1722
Abstract:
Context: Most adrenal incidentalomas are nonfunctioning adrenocortical adenomas (ACAs). Adrenocortical carcinomas (ACCs) are rare but should be recognized at an early stage. Objective: The objective of the study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) to predict malignancy in patients without a previous history of cancer. Design: This was a prospective, multicenter study from 2001 to 2006. Setting: The study was conducted at a network of seven university hospitals in Paris. Patients: Seventy-seven patients were included. All underwent surgery because of hypersecretory and/or growing benign lesions (n = 18), obvious ACCs (n = 21), or radiologically indeterminate lesions (n = 38). Main Outcome Measure: The degree of 18F-FDG PET uptake [maximum standardized uptake value (maxSUV)] was related to the pathological findings serving as a reference, and its diagnostic value was compared with that of computerized tomography (CT) scan. Results: Pathology eventually diagnosed 43 ACAs, 22 ACCs, and 12 nonadrenocortical lesions. Using a cutoff value above 1.45 for adrenal to liver maxSUV ratio, the sensitivity and specificity to distinguish ACAs from ACCs were, respectively, 1.00 (95% confidence interval 0.85–1.00) and 0.88 (95% confidence interval 0.75–0.96). Among the 38 indeterminate lesions at CT scan, we could analyze a subgroup of 16 adrenocortical tumors with high unenhanced density ( & gt;10 HU) and an inappropriate washout: 18F-FDG PET correctly predicted the benignity in 13 of 15 ACAs. Conclusions: In a multidisciplinary team approach, 18F-FDG PET helps to manage suspicious CT scan lesions. An adrenal to liver maxSUV ratio less than 1.45 is highly predictive of a benign lesion.
Type of Medium:
Online Resource
ISSN:
0021-972X
,
1945-7197
DOI:
10.1210/jc.2008-2302
Language:
English
Publisher:
The Endocrine Society
Publication Date:
2009
detail.hit.zdb_id:
2026217-6
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