Publication Date:
2013-10-12
Description:
In this study, we attempted to adopt the auxotrophic mevalonate synthase mutant ( mvaS mutant) of Staphylococcus aureus to study whether a nongrowing but viable cell population is tolerant to bactericidal antibiotics. The mevalonate-depleted nongrowing mvaS mutant was found tolerant to antibiotics. Surprisingly, after prolonged cultivation, we obtained stable mvaS variants that were able to grow without mevalonate, which suggested unknown mechanisms for compensating undecaprenyl pyrophosphate production without mevalonate in S. aureus .
Print ISSN:
0066-4804
Electronic ISSN:
1098-6596
Topics:
Biology
,
Medicine
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