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  • 1
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 47 (1998), S. 185-193 
    ISSN: 0006-3525
    Keywords: surface modification ; template approach ; self-assembly ; protein monolayer ; molecular imprinting ; implant material ; protein adsorption - X-ray photoelectron spectroscopy ; surface pattern - biocompatibility of, cyclic peptide for, porphyrin for ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Protein layers are deposited on the surface of implanted biomaterials. Better understanding of the interaction between the surface protein layers and the biological system would lead to the development of future biomaterials with superior biocompatibilities. Well-organized biorecognizable surfaces can be formed with various template molecules that provide an appropriate spacing for the attachment of recognition groups to the modified surface. Silane coupling reagents, porphyrin thiols, and cyclic peptides are being used as templates to introduce nano-scale patterns on solid surfaces. Synthesis of these templates and characterization of the modified surface are described. © 1998 John Wiley & Sons, Inc. Biopoly 47: 185-193, 1998
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: In a study of the transient behavior of a series of nylon 6/6 yarns differing systematically in mechanical properties, the effects of high-speed, transverse missile impact upon yarn specimens were observed by high-speed photography. The loss in missile kinetic energy was determined directly from the reduction in missile velocity and was studied as a function of yarn tenacity and missile impact velocity. The shape of the missile energy loss curves was due to the partition of missile energy into yarn kinetic energy and yarn strain energy. The missile energy losses and yarn dynamic breaking strains were compared to static breaking energies and breaking strains for these yarns. The observed trends are discussed in terms of the differing yarn tenacities and test rates.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2015-02-21
    Description: Central peaks of impact craters contain materials exhumed from depth and therefore, investigation of these materials provide clues to subsurface geology and mineralogy. A global spectral survey of central peaks of Martian impact craters between 10–200 km diameter was completed using Mars Odyssey Thermal Emission Imaging System (THEMIS) data. Twenty-six central peaks with distinctive spectral signatures from surrounding plains were identified and characterized with thermal infrared and visible/near-infrared data. The distribution of spectrally distinct central peaks (SDCPs) shows some degree of regional clustering, with most craters found in western Noachis Terra, Tyrrhena Terra, within the northern rim of Hellas Basin, and fewer in the northern lowlands. With the exception of four craters in western Noachis Terra, SDCPs contain only one spectrally distinct unit at THEMIS resolution (100 m/pixel). The maximum number of spectrally distinct units observed was three, in Jones and Ostrov craters. The western Noachis Terra SDCPs may expose crustal stratigraphies of multiple igneous compositions or impact materials from Argyre. In the highlands, most SDCP units are consistent with enrichments in olivine or pyroxene relative to surrounding plains, suggesting olivine- and pyroxene-basaltic lithologies; few are olivine- and pyroxene-poor. No spatial trend in spectrally-derived compositions of SDCPs was observed. Three SDCPs contain THEMIS signatures consistent with high abundances of phyllosilicates, which may contain the most phyllosilicate-rich lithologies found in central peak-associated materials globally.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 4
    Publication Date: 2015-01-11
    Description: Changes in the sky noise spectrum are used to characterize perturbations in the ionosphere. Observations were made at the same sidereal time on multiple days using a calibrated broadband dipole and radio spectrometer covering 80 to 185 MHz. In this frequency range, an ionospheric opacity perturbation changes both the electron thermal emission from the ionosphere and the absorption of the sky noise background. For the first time, these changes are confirmed to have the expected spectral signature and are used to derive the opacity and electron temperature associated with the perturbations as a function of local time. The observations were acquired at the Murchison Radio-astronomy Observatory in Western Australia from 18 April 2014 to 6 May 2014. They show perturbations that increase at sunrise, continue during the day, and decline after sunset. Magnitudes corresponding to an opacity perturbation of about 1 percent at 150 MHz with a typical electron temperature of about 800 K, were measured for the strongest perturbations.
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
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  • 5
    Publication Date: 2014-10-21
    Description: Since the 1960s, simian hemorrhagic fever virus (SHFV; Nidovirales , Arteriviridae ) has caused highly fatal outbreaks of viral hemorrhagic fever in captive Asian macaque colonies. However, the source(s) of these outbreaks and the natural reservoir(s) of this virus remain obscure. Here we report the identification of two novel, highly divergent simian arteriviruses related to SHFV, Mikumi yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SWBV-1), in wild and captive baboons, respectively, and demonstrate the recent transmission of SWBV-1 among captive baboons. These findings extend our knowledge of the genetic and geographic diversity of the simian arteriviruses, identify baboons as a natural host of these viruses, and provide further evidence that baboons may have played a role in previous outbreaks of simian hemorrhagic fever in macaques, as has long been suspected. This knowledge should aid in the prevention of disease outbreaks in captive macaques and supports the growing body of evidence that suggests that simian arterivirus infections are common in Old World monkeys of many different species throughout Africa. IMPORTANCE Historically, the emergence of primate viruses both in humans and in other primate species has caused devastating outbreaks of disease. One strategy for preventing the emergence of novel primate pathogens is to identify microbes with the potential for cross-species transmission in their natural state within reservoir species from which they might emerge. Here, we detail the discovery and characterization of two related simian members of the Arteriviridae family that have a history of disease emergence and host switching. Our results expand the phylogenetic and geographic range of the simian arteriviruses and define baboons as a natural host for these viruses. Our findings also identify a potential threat to captive macaque colonies by showing that simian arteriviruses are actively circulating in captive baboons.
    Print ISSN: 0022-538X
    Electronic ISSN: 1098-5514
    Topics: Medicine
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  • 6
    Publication Date: 2015-12-31
    Description: Wild nonhuman primates are immediate sources and long-term reservoirs of human pathogens. However, ethical and technical challenges have hampered the identification of novel blood-borne pathogens in these animals. We recently examined RNA viruses in plasma from wild African monkeys and discovered several novel, highly divergent viruses belonging to the family Arteriviridae . Close relatives of these viruses, including simian hemorrhagic fever virus, have caused sporadic outbreaks of viral hemorrhagic fever in captive macaque monkeys since the 1960s. However, arterivirus infection in wild nonhuman primates had not been described prior to 2011. The arteriviruses recently identified in wild monkeys have high sequence and host species diversity, maintain high viremia, and are prevalent in affected populations. Taken together, these features suggest that the simian arteriviruses may be "preemergent" zoonotic pathogens. If not, this would imply that biological characteristics of RNA viruses thought to facilitate zoonotic transmission may not, by themselves, be sufficient for such transmission to occur.
    Print ISSN: 0022-538X
    Electronic ISSN: 1098-5514
    Topics: Medicine
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  • 7
    Publication Date: 2012-07-25
    Description: Aims To evaluate the haemodynamic effect of acute procedural success (APS) after MitraClip therapy in patients with haemodynamic decompensation. Methods and results Of 107 patients, 79 achieved APS after MitraClip implantation. The increase in cardiac index (CI) was primarily detected in patients with a low baseline CI (2.0 ± 0.5 to 2.5 ± 5 L/min/m 2 , P 〈 0.001). There was a decrease in left ventricular end-diastolic pressure (LVEDP) (20 ± 5 to 13 ± 5 mmHg, P = 0.002) and mean pulmonary capillary wedge pressure (PCWPm) (20 ± 4 to 16 ± 5 mmHg, P = 0.001) in patients with values 〉15 mmHg at baseline, and a decrease in mean pulmonary artery systolic (PAPm) (36 ± 4 to 29 ± 7 mmHg P = 0.003) in those with values 〉30 mmHg before the MitraClip procedure. Patients with decompensation compared with patients with compensation experienced significant reduction in LVEDP (–8.3 ± 11.9 mmHg vs. –0.2 ± 4.5 mmHg, P = 0.009), a reduction in PCWPm (–3.5 ± 5.6 mmHg vs. 1.9 ± 4.7 mmHg, P 〈 0.001), and a reduction in PAPm (–8 ± 9 mmHg vs. 3 ± 6 mmHg, P 〈 0.001). Conclusion The favourable haemodynamic effects of MitraClip therapy on CI were primarily detected in patients with low CI before the procedure, and improvements in left-sided filling pressure and PAP were primarily seen in those with elevated values at baseline.
    Print ISSN: 1388-9842
    Electronic ISSN: 1879-0844
    Topics: Medicine
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