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  • 1
    Online Resource
    Online Resource
    Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-10-26)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-10-26)
    Abstract: In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62.0%, mean age 56.4 years) and 3206 dialysis patients (male 61.8%, mean age 67.7 years) were examined. Three-month mortality in kidney transplant recipients was 16.9% in males and 18.6% in females (p = 0.31) and in dialysis patients 27.1% in males and 21.9% in females (p = 0.001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0.89 (95% CI 65, 1.23, p = 0.49) in kidney transplant recipients and 1.33 (95% CI 1.13, 1.56, p = 0.001) in dialysis patients (p interaction  = 0.02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1.39 (95% CI 1.02, 1.89, p = 0.04) in males and 2.04 (95% CI 1.40, 2.97, p  〈  0.001) in females (p interaction  = 0.02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-22657-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 2
    Online Resource
    Online Resource
    Pliocene oceanic seaways and global climate
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-01-05)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-01-05)
    Abstract: Tectonically induced changes in oceanic seaways had profound effects on global and regional climate during the Late Neogene. The constriction of the Central American Seaway reached a critical threshold during the early Pliocene ~4.8–4 million years (Ma) ago. Model simulations indicate the strengthening of the Atlantic Meridional Overturning Circulation (AMOC) with a signature warming response in the Northern Hemisphere and cooling in the Southern Hemisphere. Subsequently, between ~4–3 Ma, the constriction of the Indonesian Seaway impacted regional climate and might have accelerated the Northern Hemisphere Glaciation. We here present Pliocene Atlantic interhemispheric sea surface temperature and salinity gradients (deduced from foraminiferal Mg/Ca and stable oxygen isotopes, δ 18 O) in combination with a recently published benthic stable carbon isotope (δ 13 C) record from the southernmost extent of North Atlantic Deep Water to reconstruct gateway-related changes in the AMOC mode. After an early reduction of the AMOC at ~5.3 Ma, we show in agreement with model simulations of the impacts of Central American Seaway closure a strengthened AMOC with a global climate signature. During ~3.8–3 Ma, we suggest a weakening of the AMOC in line with the global cooling trend, with possible contributions from the constriction of the Indonesian Seaway.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep39842
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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  • 3
    Online Resource
    Online Resource
    Horizontal transfer of tRNA genes to mitochondrial plasmids facilitates gene loss from fungal mitochondrial DNA
    Springer Science and Business Media LLC ; 2023
    In:  Current Genetics Vol. 69, No. 1 ( 2023-02), p. 55-65
    Details
    In: Current Genetics, Springer Science and Business Media LLC, Vol. 69, No. 1 ( 2023-02), p. 55-65
    Abstract: Fungal and plant mitochondria are known to exchange DNA with retroviral plasmids. Transfer of plasmid DNA to the organellar genome is best known and occurs through wholesale insertion of the plasmid. Less well known is the transfer of organellar DNA to plasmids, in particular tRNA genes. Presently, it is unknown whether fungal plasmids can adopt mitochondrial functions such as tRNA production through horizontal gene transfer. In this paper, we studied the exchange of DNA between fungal linear plasmids and fungal mtDNA, mainly focusing on the basidiomycete family Lyophyllaceae. We report at least six independent transfers of complete tRNA genes to fungal plasmids. Furthermore, we discovered two independent cases of loss of a tRNA gene from a fungal mitochondrial genome following transfer of such a gene to a linear mitochondrial plasmid. We propose that loss of a tRNA gene from mtDNA following its transfer to a plasmid creates a mutualistic dependency of the host mtDNA on the plasmid. We also find that tRNA genes transferred to plasmids encode codons that occur at the lowest frequency in the host mitochondrial genomes, possibly due to a higher number of unused transcripts. We discuss the potential consequences of mtDNA transfer to plasmids for both the host mtDNA and the plasmid.
    Type of Medium: Online Resource
    ISSN: 0172-8083 , 1432-0983
    URL: Article
    DOI: 10.1007/s00294-022-01259-7
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1458984-9
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Episodic release of CO2 from the high-latitude North Atlantic Ocean during the last 135 kyr
    Springer Science and Business Media LLC ; 2017
    In:  Nature Communications Vol. 8, No. 1 ( 2017-02-22)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2017-02-22)
    Abstract: Antarctic ice cores document glacial-interglacial and millennial-scale variability in atmospheric pCO 2 over the past 800 kyr. The ocean, as the largest active carbon reservoir on this timescale, is thought to have played a dominant role in these pCO 2 fluctuations, but it remains unclear how and where in the ocean CO 2 was stored during glaciations and released during (de)glacial millennial-scale climate events. The evolution of surface ocean pCO 2 in key locations can therefore provide important clues for understanding the ocean’s role in Pleistocene carbon cycling. Here we present a 135-kyr record of shallow subsurface pCO 2 and nutrient levels from the Norwegian Sea, an area of intense CO 2 uptake from the atmosphere today. Our results suggest that the Norwegian Sea probably acted as a CO 2 source towards the end of Heinrich stadials HS1, HS4 and HS11, and may have contributed to the increase in atmospheric pCO 2 at these times.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/ncomms14498
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2553671-0
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  • 5
    Online Resource
    Online Resource
    Relation between myocardial uptake of thallium-201 chloride and fluorine-18 fluorodeoxyglucose imaged with single-photon emission tomography in normal individuals
    Springer Science and Business Media LLC ; 1995
    In:  European Journal of Nuclear Medicine Vol. 22, No. 1 ( 1995-1), p. 56-60
    Details
    In: European Journal of Nuclear Medicine, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 1995-1), p. 56-60
    Type of Medium: Online Resource
    ISSN: 0340-6997 , 1619-7089
    URL: Article
    DOI: 10.1007/BF00997248
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1995
    detail.hit.zdb_id: 2098375-X
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  • 6
    Online Resource
    Online Resource
    Performance of five automated white matter hyperintensity segmentation methods in a multicenter dataset
    Springer Science and Business Media LLC ; 2019
    In:  Scientific Reports Vol. 9, No. 1 ( 2019-11-14)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-11-14)
    Abstract: White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease, that is increasingly studied with large, pooled multicenter datasets. This data pooling increases statistical power, but poses challenges for automated WMH segmentation. Although there is extensive literature on the evaluation of automated WMH segmentation methods, such evaluations in a multicenter setting are lacking. We performed WMH segmentations in sixty patients scanned on six different magnetic resonance imaging (MRI) scanners (10 patients per scanner) using five freely available and fully-automated WMH segmentation methods (Cascade, kNN-TTP, Lesion-TOADS, LST-LGA and LST-LPA). Different MRI scanner vendors and field strengths were included. We compared these automated WMH segmentations with manual WMH segmentations as a reference. Performance of each method both within and across scanners was assessed using spatial and volumetric correspondence with the reference segmentations by Dice’s similarity coefficient (DSC) and intra-class correlation coefficient (ICC) respectively. We found the best performance, both within and across scanners, for kNN-TTP, followed by LST-LPA and LST-LGA, with worse performance for Lesion-TOADS and Cascade. Our findings can serve as a guide for choosing a method and also highlight the importance to further improve and evaluate consistency of methods in a multicenter setting.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-019-52966-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    Deglacial bottom water warming intensified Arctic methane seepage in the NW Barents Sea
    Springer Science and Business Media LLC ; 2021
    In:  Communications Earth & Environment Vol. 2, No. 1 ( 2021-09-09)
    Details
    In: Communications Earth & Environment, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2021-09-09)
    Abstract: Changes in the Arctic climate-ocean system can rapidly impact carbon cycling and cryosphere. Methane release from the seafloor has been widespread in the Barents Sea since the last deglaciation, being closely linked to changes in pressure and bottom water temperature. Here, we present a post-glacial bottom water temperature record (18,000–0 years before present) based on Mg/Ca in benthic foraminifera from an area where methane seepage occurs and proximal to a former Arctic ice-sheet grounding zone. Coupled ice sheet-hydrate stability modeling shows that phases of extreme bottom water temperature up to 6 °C and associated with inflow of Atlantic Water repeatedly destabilized subsurface hydrates facilitating the release of greenhouse gasses from the seabed. Furthermore, these warming events played an important role in triggering multiple collapses of the marine-based Svalbard-Barents Sea Ice Sheet. Future warming of the Atlantic Water could lead to widespread disappearance of gas hydrates and melting of the remaining marine-terminating glaciers.
    Type of Medium: Online Resource
    ISSN: 2662-4435
    URL: Article
    DOI: 10.1038/s43247-021-00264-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 3037243-4
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