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  • 1
    Online Resource
    Online Resource
    Abnormal auditory tonotopy in patients with schizophrenia
    Springer Science and Business Media LLC ; 2019
    In:  npj Schizophrenia Vol. 5, No. 1 ( 2019-10-02)
    Details
    In: npj Schizophrenia, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2019-10-02)
    Abstract: Auditory hallucinations are among the most prevalent and most distressing symptoms of schizophrenia. Despite significant progress, it is still unclear whether auditory hallucinations arise from abnormalities in primary sensory processing or whether they represent failures of higher-order functions. To address this knowledge gap, we capitalized on the increased spatial resolution afforded by ultra-high field imaging at 7 Tesla to investigate the tonotopic organization of the auditory cortex in patients with schizophrenia with a history of recurrent hallucinations. Tonotopy is a fundamental feature of the functional organization of the auditory cortex that is established very early in development and predates the onset of symptoms by decades. Compared to healthy participants, patients showed abnormally increased activation and altered tonotopic organization of the auditory cortex during a purely perceptual task, which involved passive listening to tones across a range of frequencies (88–8000 Hz). These findings suggest that the predisposition to auditory hallucinations is likely to be predicated on abnormalities in the functional organization of the auditory cortex and which may serve as a biomarker for the early identification of vulnerable individuals.
    Type of Medium: Online Resource
    ISSN: 2334-265X
    URL: Article
    DOI: 10.1038/s41537-019-0084-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2813844-2
    detail.hit.zdb_id: 3133210-9
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  • 2
    Online Resource
    Online Resource
    Early and Late Age of Seizure Onset have a Differential Impact on Brain Resting-State Organization in Temporal Lobe Epilepsy
    Springer Science and Business Media LLC ; 2015
    In:  Brain Topography Vol. 28, No. 1 ( 2015-1), p. 113-126
    Details
    In: Brain Topography, Springer Science and Business Media LLC, Vol. 28, No. 1 ( 2015-1), p. 113-126
    Type of Medium: Online Resource
    ISSN: 0896-0267 , 1573-6792
    URL: Article
    DOI: 10.1007/s10548-014-0366-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2015003-9
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  • 3
    Online Resource
    Online Resource
    Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study
    Springer Science and Business Media LLC ; 2021
    In:  Molecular Psychiatry Vol. 26, No. 9 ( 2021-09), p. 4905-4918
    Details
    In: Molecular Psychiatry, Springer Science and Business Media LLC, Vol. 26, No. 9 ( 2021-09), p. 4905-4918
    Abstract: Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available on 1476 IMAGEN participants aged 14 years and from a subsample reassessed at age 19 years ( n  = 714). We applied sparse canonical correlation analyses (sCCA) to the cross-sectional and longitudinal data to extract modes with maximum covariation between neuroimaging and non-imaging measures. Separate sCCAs for cortical thickness, cortical surface area and subcortical volumes confirmed that each imaging phenotype was correlated with non-imaging features (sCCA r range: 0.30–0.65, all P FDR   〈  0.001). Total intracranial volume and global measures of cortical thickness and surface area had the highest canonical cross-loadings (| ρ | = 0.31−0.61). Age, physical growth and sex had the highest association with adolescent brain structure (| ρ | = 0.24−0.62); at baseline, further significant positive associations were noted for cognitive measures while negative associations were observed at both time points for prenatal parental smoking, life events, and negative affect and substance use in youth (|ρ| = 0.10−0.23). Sex, physical growth and age are the dominant influences on adolescent brain development. We highlight the persistent negative influences of prenatal parental smoking and youth substance use as they are modifiable and of relevance for public health initiatives.
    Type of Medium: Online Resource
    ISSN: 1359-4184 , 1476-5578
    URL: Article
    DOI: 10.1038/s41380-020-0757-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1502531-7
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  • 4
    Online Resource
    Online Resource
    The forest, the trees, and the leaves across adulthood: Age-related changes on a visual search task containing three-level hierarchical stimuli
    Springer Science and Business Media LLC ; 2022
    In:  Attention, Perception, & Psychophysics Vol. 84, No. 3 ( 2022-04), p. 1004-1015
    Details
    In: Attention, Perception, & Psychophysics, Springer Science and Business Media LLC, Vol. 84, No. 3 ( 2022-04), p. 1004-1015
    Abstract: Selecting relevant visual information in complex scenes by processing either global information or local parts helps us act efficiently within our environment and achieve goals. A global advantage (faster global than local processing) and global interference (global processing interferes with local processing) comprise an evidentiary global precedence phenomenon in early adulthood. However, the impact of healthy aging on this phenomenon remains unclear. As such, we collected behavioral data during a visual search task, including three-levels hierarchical stimuli (i.e., global, intermediate, and local levels) with several hierarchical distractors, in 50 healthy adults (26 younger (mean age: 26 years) and 24 older (mean age: 62 years)). Results revealed that processing information presented at the global and intermediate levels was independent of age. Conversely, older adults were slower for local processing compared to the younger adults, suggesting lower efficiency to deal with visual distractors during detail-oriented visual search. Although healthy older adults continued exhibiting a global precedence phenomenon, they were disproportionately less efficient during local aspects of information processing, especially when multiple visual information was displayed. Our results could have important implications for many life situations by suggesting that visual information processing is impacted by healthy aging, even with similar visual stimuli objectively presented.
    Type of Medium: Online Resource
    ISSN: 1943-3921 , 1943-393X
    URL: Article
    DOI: 10.3758/s13414-021-02438-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2480891-X
    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    Personalized estimates of morphometric similarity in bipolar disorder and schizophrenia
    Springer Science and Business Media LLC ; 2020
    In:  npj Schizophrenia Vol. 6, No. 1 ( 2020-12-04)
    Details
    In: npj Schizophrenia, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2020-12-04)
    Abstract: Bipolar disorder and schizophrenia are associated with brain morphometry alterations. This study investigates inter-individual variability in brain structural profiles, both within diagnostic groups and between patients and healthy individuals. Brain morphometric measures from three independent samples of patients with schizophrenia ( n  = 168), bipolar disorder ( n  = 122), and healthy individuals ( n  = 180) were modeled as single vectors to generated individualized profiles of subcortical volumes and regional cortical thickness. These profiles were then used to compute a person-based similarity index (PBSI) for subcortical volumes and for regional cortical thickness, to quantify the within-group similarity of the morphometric profile of each individual to that of the other participants in the same diagnostic group. There was no effect of diagnosis on the PBSI for subcortical volumes. In contrast, compared to healthy individuals, the PBSI for cortical thickness was lower in patients with schizophrenia (effect size = 0.4, p  ≤ 0.0002), but not in patients with bipolar disorder. The results were robust and reproducible across samples. We conclude that disease mechanisms for these disorders produce modest inter-individual variations in brain morphometry that should be considered in future studies attempting to cluster patients in subgroups.
    Type of Medium: Online Resource
    ISSN: 2334-265X
    URL: Article
    DOI: 10.1038/s41537-020-00128-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2813844-2
    detail.hit.zdb_id: 3133210-9
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  • 6
    Online Resource
    Online Resource
    Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-02-16)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-02-16)
    Abstract: Anorexia Nervosa has been associated with white matter abnormalities implicating subcortical abnormal myelination. Extending these findings to intracortical myelin has been challenging but ultra-high field neuroimaging offers new methodological opportunities. To test the integrity of intracortical myelin in AN we used 7 T neuroimaging to acquire T1-weighted images optimized for intracortical myelin from seven females with AN (age range: 18–33) and 11 healthy females (age range: 23–32). Intracortical T 1 values (inverse index of myelin concentration) were extracted from 148 cortical regions at ten depth-levels across the cortical ribbon. Across all cortical regions, these levels were averaged to generate estimates of total intracortical myelin concentration and were clustered using principal component analyses into two clusters; the outer cluster comprised T 1 values across depth-levels ranging from the CSF boundary to the middle of the cortical regions and the inner cluster comprised T 1 values across depth-levels ranging from the middle of the cortical regions to the gray/white matter boundary. Individuals with AN exhibited higher T 1 values (i.e., decreased intracortical myelin concentration) in all three metrics. It remains to be established if these abnormalities result from undernutrition or specific lipid nutritional imbalances, or are trait markers; and whether they may contribute to neurobiological deficits seen in AN.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-06113-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    Baseline brain structural and functional predictors of clinical outcome in the early course of schizophrenia
    Springer Science and Business Media LLC ; 2020
    In:  Molecular Psychiatry Vol. 25, No. 4 ( 2020-4), p. 863-872
    Details
    In: Molecular Psychiatry, Springer Science and Business Media LLC, Vol. 25, No. 4 ( 2020-4), p. 863-872
    Type of Medium: Online Resource
    ISSN: 1359-4184 , 1476-5578
    URL: Article
    DOI: 10.1038/s41380-018-0269-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1502531-7
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