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  • 1
    ISSN: 1572-8595
    Keywords: autonomic nervous system ; basket catheter ; neural stimulation ; heart rate ; A-V conduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We previously showed that parasympathetic stimulation by a basket electrode catheter (BEC) positioned in the superior vena cava (SVC) can slow sinus rate (SR) or ventricular response (VR) during atrial fibrillation (AF). In 11 dogs, anesthetized with Na-pentobarbital, standard ECG leads II and aVR, blood pressure and right atrial electrograms were continuously monitored. Two different BEC configurations (B1, B2) were tested in the SVC. B1 consisted of five metal splines, each 3cm in length. Stimulation was applied between adjacent splines. B2 consisted of 2 electrodes at opposite ends of each of 5 splines and a larger electrode at the middle of each spline. Stimulation was delivered between the two end electrodes and the middle electrode on the same arm. Stimulation consisted of square wave stimuli, each 0.1msec duration, frequency 20Hz at voltages from 1–40V. Six dogs were studied with B1 and five were studied with the B2 configuration. The average voltage required to produce a 50% decrease in heart rate was 22± 12V when stimulating between adjacent splines (B1) compared to 10± 5V when stimulating along a single spline (B2), a 55% decrease (p≤0.05). During AF, the voltage required to reduce the average ventricular rate to 100beats/min was 19± 13V for B1 and 8± 5V for B2, a 58% reduction (p≤0.05). Thus, the significant difference between B1 and B2 and in slowing SR or VR during AF was probably due to a greater current density delivered with B2 to the endovascular wall and adjacent neural elements.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0649
    Keywords: 42.80 ; 42.65 ; 42.70
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Room-temperature two-element latching circuits are experimentally demonstrated using GaAs multiple-quantum-well (MQW) nonlinear etalons under single-wavelength bistable operation. Signal power gains of up to 4 and contrast ratios of 10 have been achieved at milliwatt power levels with 1-μs pulses, which will allow the construction of more complicated digital optical circuits using diode lasers as the light sources. The problems of applying these nonlinear etalons to fast optical signal processing are also discussed. Numerical simulations show that the gain vanishes as the pulse duration decreases and approaches the carrier lifetime.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1437-9813
    Keywords: Balloon dilation ; Ureteral reimplantation ; Ureteral stricture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Obstruction of the ureterovesical junction is an uncommon but well-recognized complication of ureteral reimplantation that traditionally has been treated by surgical correction [1, 5–9]. We report our experience with antegrade balloon dilation (ABD) of these strictures in two children. Obstruction was confirmed by diuretic renogram and pressure perfusion studies prior to ABD. Clinical follow-up was done at 3 months and 14 months, and ultrasonographic studies revealed resolution of the hydronephrosis. In addition, diuretic renograms showed complete washout of radiotracer. Morbidity was limited to episodes of pyelonephritis that readily responded to medical management. ABD of ureteral strictures is a relatively simple procedure with a potential for a high success rate and low morbidity. This modality should be considered as the first line of treatment in patients with distal ureteral obstruction after reimplantation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Earth, moon and planets 44 (1989), S. 251-264 
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Iapetus (S8) is unique in our solar system in that the albedo of its leading hemisphere is only 0.05 while that of the trailing side is 0.5. Several existing hypotheses are examined and found inadequate. Photometric studies of the dark side are compared to comet nuclei and class D asteroids. It is hypothesized that in the last 106–108 yrs the leading side suffered a high-velocity collision with a cometary body of mass 1013–1015 kg and traveling at a speed of 20 km s−1. About 5–16% of the excavated material was ejected into space, where the vaporized ices dissipated while the dark carbonaceous/silicate material was reaccreted on the leading side. The collision, although not sufficient to break Iapetus' tidal lock, resulted in a period of oscillation of about 5 yr. Until tidal friction reasserted a lock, the oscillation gave rise to the ‘longitude effect’, viz., the observed fact that the dark material covers more than 220
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1420-9136
    Keywords: Monsoon circulation ; Anomaly patterns ; effect of ocean surface temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The time mean response of the summer monsoon circulation, as simulated by the 2.5° latitude-longitude resolution, July version of the National Center for Atmospheric Research (NCAR) General Circulation Model (GCM), to a variety of Indian Ocean surface temperature anomaly patterns is examined. In separate experiments, prescribed changes in surface temperature are imposed in the Western Arabian Sea, the Eastern Arbian Sea or the Central Indian Ocean. The influence of these anomaly patterns on the simulated summer monsoon circulation is evaluated in terms of the geographical distribution of the prescribed change response for any field of interest. This response is defined as the grid point difference between a 30-day mean from a prescribed change experiment and the ensemble average of the 30-day means from the control population for which the same set of climatological ocean surface temperatures are used in each simulation. The statistical significance of such a prescribed change response is estimated by relating the normalized response (defined as the ratio of the prescribed change response to the standard deviation of 30-day means as estimated from the finite sample of control cases) to the classical Student'st-statistic. Using this methodology, the most prominent and statistically significant features of the model's response are increased vertical velocity and precipitation over warm anomalies and typically decreased vertical velocity and precipitation in some preferred region adjacent to the prescribed change region. In the case of cold anomalies, these changes are of opposite sign. However, none of the imposed anomaly patterns produces substantial or statistically significant precipitation changes over large areas of the Indian sub-continent. The only evidence of a major nonlocal effect is found in the experiment with a large positive anomaly (+3°C) in the Central Indian Ocean. In this instance, vertical velocity and precipitation are reduced over Malaysia and a large area of the Equatorial Western Pacific Ocean. Thus, while these anomaly experiments produce only a local response (for the most part), it is hoped, as one of the purposes of the planned Monsoon Experiment (MONEX), that the necessary data will be provided to produce detailed empirical evidence on the extent to which Indian Ocean surface temperature anomalies correlate with precipitation anomalies over the Indian subcontinent—a correlation which generally does not appear in these GCM results.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 57 (2000), S. 1880-1893 
    ISSN: 1420-9071
    Keywords: Key words. Cobalamin; vitamin B12; tetrapyrrole; precorrin; chelatase; pathway.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The biosynthesis of cobalamin (vitamin B12) is described, revealing how the concerted action of around 30 enzyme-mediated steps results in the synthesis of one of Nature's most structurally complex ‘small molecules’. The plethora of genome sequences has meant that bacteria capable of cobalamin synthesis can be easily identified and their biosynthetic genes compared. Whereas only a few years ago cobalamin synthesis was thought to occur by one of two routes, there are apparently a number of variations on these two pathways, where the major differences seem to be concerned with the process of ring contraction. A comparison of what is currently known about these pathways is presented. Finally, the process of cobalt chelation is discussed and the structure/function of the cobalt chelatase associated with the oxygen-independent pathway (CbiK) is described.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Components of interannual, intermonthly, and total monthly variability of lower troposphere temperature are calculated from a global coupled ocean-atmosphere general circulation model (GCM) (referred to as the coupled model), from the same atmospheric model coupled to a nondynamic mixedlayer ocean (referred to as the mixed-layer model), and from microwave sounding unit (MSU) satellite data. The coupled model produces most features of intermonthly and interannual variability compared to the MSU data, but with somewhat reduced amplitude in the extratropics and increased variability in the tropical western Pacific and tropical Atlantic. The relatively short 14-year period of record of the MSU data precludes definitive conclusions about variability in the observed system at longer time scales (e.g., decadal or longer). Different 14-year periods from the coupled model show variability on those longer time scales that were noted in Part 1 of this series. The relative contributions of intermonthly and interannual variability that make up the total monthly variability are similar between the coupled model and the MSU data, suggesting that similar mechanisms are at work in both the model and observed system. These include El Niño-Southern Oscillation (ENSO)-type interannual variability in the tropics, Madden-Julian Oscillation (MJO) type intermonthly variability in the tropics, and blocking-type intermonthly variability in the extratropics. Manifestations of all of these features have been noted in various versions of the model. Significant changes of variability noted in the coupled model with doubled carbon dioxide differ from those in our mixed-layer model and earlier studies with mixed-layer models. In particular, in our mixed-layer model intermonthly and interannual variability changes are similar with a mixture of regional increases and decreases, but with mainly decreases in the zonal mean from about 20°S to 60°N and near 60°S. In the coupled model, intermonthly and interannual changes of variability with doubled CO2 show mostly increases of tropical interannual variability and decreases of intermonthly variability near 60°N. These changes in the tropics are related to changes in ENSO, the south Asian monsoon, and other regional hydrological regimes, while the alterations near 60°N are likely associated with changes in blocking activity. These results point to the important contribution from ENSO seen in the coupled model and the MSU data that are not present in the mixed-layer model.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A version of the National Center for Atmospheric Research community climate model — a global, spectral (R15) general circulation model — is coupled to a coarse-grid (5° latitude-] longitude, four-layer) ocean general circulation model to study the response of the climate system to increases of atmospheric carbon dioxide (CO2). Three simulations are run: one with an instantaneous doubling of atmospheric CO2 (from 330 to 660 ppm), another with the CO2 concentration starting at 330 ppm and increasing linearly at a rate of 1% per year, and a third with CO2 held constant at 330 pm. Results at the end of 30 years of simulation indicate a globally averaged surface air temperature increase of 1.6° C for the instantaneous doubling case and 0.7°C for the transient forcing case. Inherent characteristics of the coarse-grid ocean model flow sea-surface temperatures (SSTs) in the tropics and higher-than-observed SSTs and reduced sea-ice extent at higher latitudes] produce lower sensitivity in this model after 30 years than in earlier simulations with the same atmosphere coupled to a 50-m, slab-ocean mixed layer. Within the limitations of the simulated meridional overturning, the thermohaline circulation weakens in the coupled model with doubled CO2 as the high-latitude ocean-surface layer warms and freshens and westerly wind stress is decreased. In the transient forcing case with slowly increasing CO2 (30% increase after 30 years), the zonal mean warming of the ocean is most evident in the surface layer near 30°–50° S. Geographical plots of surface air temperature change in the transient case show patterns of regional climate anomalies that differ from those in the instantaneous CO2 doubling case, particularly in the North Atlantic and northern European regions. This suggests that differences in CO2 forcing in the climate system are important in CO2 response in regard to time-dependent climate anomaly regimes. This confirms earlier studies with simple climate models that instantaneous CO2 doubling simulations may not be analogous in all respects to simulations with slowly increasing CO2.
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  • 9
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We have developed an improved version of a world ocean model with the intention of coupling to an atmospheric model. This article documents the simulation capability of this 1° global ocean model, shows improvements over our earlier 5° version, and compares it to features simulated with a 0.5° model. These experiments use a model spin-up methodology whereby the ocean model can subsequently be coupled to an atmospheric model and used for order 100-year coupled model integrations. With present-day computers, 1° is a reasonable compromise in resolution that allows for century-long coupled experiments. The 1° ocean model is derived from a 0.5°-resolution model developed by A. Semtner (Naval Postgraduate School) and R. Chervin (National Center for Atmospheric Research) for studies of the global eddy-resolving world ocean circulation. The 0.5° bottom topography and continental outlines have been altered to be compatible with the 1° resolution, and the Arctic Ocean has been added. We describe the ocean simulation characteristics of the 1° version and compare the result of weakly constraining (three-year time scale) the three-dimensional temperature and salinity fields to the observations below the thermocline (710 m) with the model forced only at the top of the ocean by observed annual mean wind stress, temperature, and salinity. The 1° simulations indicate that major ocean circulation patterns are greatly improved compared to the 5° version and are qualitatively reproduced in comparison to the 0.5° version. Using the annual mean top forcing alone in a 100-year simulation with the 1° version preserves the general features of the major observed temperature and salinity structure with most climate drift occurring mainly beneath the thermocline in the first 50–75 years. Because the thermohaline circulation in the 1° version is relatively weak with annual mean forcing, we demonstrate the importance of the seasonal cycle by performing two sensitivity experiments. Results show a dramatic intensification of the meridional overturning circulation (order of magnitude) with perpetual winter surface temperature forcing in the North Atlantic and strong intensification (factor of three) with perpetual early winter temperatures in that region. These effects are felt throughout the Atlantic (particularly an intensified and northward-shifted Gulf Stream outflow). In the Pacific, the temperature gradient strengthens in the thermocline, thus helping counter the systematic error of a thermocline that is too diffuse.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Climate dynamics 8 (1993), S. 117-133 
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Results from a global coupled ocean-atmosphere general circulation model (GCM) are used to perform the first in a series of studies of the various time and space scales of climate anomalies in an environment of gradually increasing carbon dioxide (CO2) (a linear transient increase of 1% per year in the coupled model). Since observed climate anomaly patterns often are computed as time-averaged differences between two periods, climate-change signals in the coupled model are defined using differences of various averaging intervals between the transient and control integrations. Annual mean surface air temperature differences for several regions show that the Northern Hemisphere warms faster than the Southern Hemisphere and that land areas warm faster than ocean. The high northern latitudes outside the North Atlantic contribute most to global warming but also exhibit great variability, while the high southern latitudes contribute the least. The equatorial tropics warm more slowly than the subtropics due to strong upwelling and mixing in the ocean. The globally averaged surface air temperature trend computed from annual mean differences for years 23–60 is 0.03
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