GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Springer  (10)
Document type
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Effect of age on response to T- and B-cell mitogens in mice congenic at theH-2 locus (1977)
    Springer
    Immunogenetics 5 (1977), S. 109-128 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract TheH-2 gene region is shown to display a considerable influence upon the age-specific response to T- and B-cell mitogens in congenic mice. Three sets of three strains each were studied, including mice congenic on A, C3H, and C57BL backgrounds. The sometimes rather striking differences in mitogenic responsiveness upon any one background were generally much less apparent in young mice than in mice examined at later stages in their lifespans, up to 28 to 30 months in the present investigation. Prior studies which failed to detect an effect ofH-2 upon mitogenic responsiveness have been limited to relatively young mice. We suggest thatH-2-linked genes may influence the maturation rates of various types of immune response, or perhaps the status of differentiation receptor sites. Different types of response may mature, peak, and decline at different ages and underH-2 contributory influence. The age-specific incidence of or susceptibility to certain diseases may in part reflect such diverse rates of change or balance among immune functions. The known associations of theH-2 andHLA systems with various malignancies and autoimmune diseases are not inconsistent with this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570468
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Differences in H-2 recombinant mice in the β-naphthoflavone inducibility of the mixed function monooxygenase, P1-450 (1987)
    Springer
    Immunogenetics 26 (1987), S. 169-173 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The influence of the major histocompatibility complex (H-2 in mouse) on induction of cytochrome P-450-dependent monooxygenase (P1-450) by the prototype polyaromatic hydrocarbon (PAH), β-naphthoflavone, was investigated in C57BL/10 Sn (B10) recombinant congenic mice. The cytosolic Ah-receptor level, as measured by specific binding with [3H]-2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, was significantly lower in B10.A and B10.A (5R) than in either B10, B10.BR, or B10.A(2R), suggesting that the D region of H-2 influences Ah-receptor levels. The responsiveness to β-naphthoflavone, as determined by increased catalytic activity toward benzo(a)pyrene and 7-ethoxycoumarin, was considerably lower in 1310, B10.A, and B10.A(5R) than in B10.BR and somewhat lower than in B10.A(2R) or B10.A(4R) mice. The lower PAH responsiveness in B10.A and B10.A(5R) correlated with their lower Ah-receptor levels while that in B10 appeared to reflect a K-A region influence on PAH responsiveness that was not due to changed Ah-receptor levels. Thus, we conclude that more than one H-2 locus may influence PAH responsiveness, and by different mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365907
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Polymorphism in the major histocompatibility complex class II genes ofPeromyscus leucopus (1989)
    Springer
    Immunogenetics 30 (1989), S. 214-217 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02421209
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Major histocompatibility complex class I genes of Peromyscus leucopus (1990)
    Springer
    Immunogenetics 32 (1990), S. 371-379 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Class I genes of the Peromyscus leucopus major histocompatibility complex (MhcPele) were examined by Southern blot hybridization, genomic cloning, and DNA sequencing. At least three distinct subtypes of Pele class I genes were discerned, which we have designated Pele-A, B, and C. The nucleotide sequences of exon 5-containing regions (encoding the transmembrane domain) suggested that Pele-A genes are homologs of mouse H-2K, D, L, and Q genes and that Pele-B genes correspond to mouse Tla genes. The Pele-C genes appeared similar to mouse M1 genes. The number of unique genes in each subtype cloned from an individual P. leucopus were 20 for Pele-A, 13 for Pele-B, and 2 for Pele-C. Three genomic clones showed cross-hybridization to both Pele-A and Pele-B gene-specific probes. Six genomic clones remained unclassified as they did not cross-hybridize to exon 5-containing probes from Pele-A, B, or C genes. The homology between the transmembrane domains of Pele class I gene subtypes was found to be similar to that observed between the transmembrane domains of H-2 subtypes (or groups). Interspecific similarity of exon 5 was found to be 81%–88% between Pele class I genes and their H-2 counterparts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00241630
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Immunologische Aspekte des Alterns (1969)
    Springer
    Journal of molecular medicine 47 (1969), S. 599-605 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01876949
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Low blood glucose levels and small islets of Langerhans in the pancreas of calorie-restricted mice (1989)
    Springer
    Age 12 (1989), S. 93-96 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we investigated the influence of long-term caloric restriction on blood glucose levels and the volume of the islets of Langerhans in the pancreases of mice. Thirty female F1 mice (SHN female × C3H male) were divided into two equal groups and raised for 11 months on either a slightly restricted “control” diet (95 Kcal per week) or a more severely restricted diet (50 Kcal per week), starting at time of weaning (4 weeks of age). These diets, designated as “isonutrient” (1), were designed so that both groups of animals received approximately equal amounts of minerals, proteins, fats and vitamins, but with carbohydrates adjusted to provide the desired calorie differences. Calorie-restricted animals (CR mice) were fed 3 days a week (Monday, Wednesday and Friday) with the restricted diet at 9:00 a.m., while control animals (C mice) were fed the control diets at 9:00 a.m. every day from Monday to Friday. On Sunday any leftover food was removed from the cages at 9:00 a.m. and both CR and C animals were allowed to fast. Fasting blood glucose levels were determined in the blood collected between 9:00 and 10:00 a.m. in 12-month-old mice from both groups on Saturday and on Monday 8 days later, at which time the mice were sacrificed for histological examination. The Saturday morning blood glucose levels (in mg/100 ml of blood) were lower in CR mice than in C mice (112±12 in CR mice and 145±16 in the C mice: p〈0.01). A similar trend was noted in the Monday morning samples: 80±19 in the CR and 108±28 in the C mice. In agreement with the blood glucose trends, histological examination of the pancreases demonstrated that the volume of the islets of Langerhans were significantly smaller in CR mice (Geometric mean 76646 μ3/islet, Geometric Standard deviation 2.10) than in C mice (Geometric mean 235578 μ m3/islet, Geometric Standard deviation 3.81)(p〈0.01). We conclude that caloric restriction decreases not only blood glucose levels, but reduces volumes of the islets of Langerhans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02432371
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Evidence for in vitro senescence of T-lymphocytes cultured from normal human peripheral blood (1981)
    Springer
    Age 4 (1981), S. 67-70 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long-term T-cell cultures from 15 donors of various ages were established using T-cell growth factor (TCGF). The donors were divided in equal numbers into three age groups, under 40, 40 to 80 and over 80 years of age. The cell cultures showed a growth pattern similar to the Hayflick Phenomenon observed in the cultured human fibroblasts with a limited total number of doublings. Cell cultures from younger groups grew longer with higher total number of doublings. The total number of doublings averaged 16.5, 12.2 and 6.5 for the cultured cells obtained from donors under 40, 40 to 80 and over 80 years of age respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431987
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Drug metabolizing capabilities and drug-induced immunosuppression in two strains of H-2 congenic mice (1984)
    Springer
    Age 7 (1984), S. 42-46 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice of the C57BL/10.RIII strain (B10.RIII) and C57BL/10.F strains (B10.F) are congenic, differing genetically at the H-2 complex. The former is H-2r and the latter H-2n. The strains differ greatly in mean survival times, with values for females being about 33 months for B10.RIII and 14 months for B10.F. In the present study, we found that B10.F mice had slightly greater uninduced levels of hepatic P-450-mediated monooxygenase activities than their congenic partners. The ratios of B10.F/B10.RIII basal levels of activities of benzo(a)pyrene (BP) hydroxylase, 7-ethoxycoumarin (7-EC) deethylase and p-nitroanisole (p-NA) demethylase were 1.5, 1.7, and 1.2, respectively (p 〈 0.05 for all comparisons). Cytochrome P-450-independent malathion and phenthoate carboxylesterase basal activities were not different between the strains. Treatment with β-naphthoflavone (β-NF) induced BP hydroxylase 6.0 fold in B10.RIII mice compared with 3.0 fold in B10.F mice. 7-EC deethylase was induced 3.4 fold in B10.RIII mice and 2.6 fold in B10.F mice. Induction of p-NA demethylase was 1.9 fold in both strains. Treatment with phenobarbital induced 7-EC to a greater degree in B10.RIII than in B10.F mice. In parallel studies on these same mice, splenic lymphocytes from the B10.RIII strain displayed a 2.0-fold higher proliferative response to concanavalin A (Con, 6,) stimulation than was seen in B10.F mice. However, after treatment with β-NF, a striking immunosuppressive effect on B10.RIII mice was noted, with a 6.6-fold decrease in Con A response, while B10.F mice were unaffected. Thus, the longer lived strain B10.RIII appears to be more susceptible to immunosuppression and AHH induction by β-NF than does its congenic partner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431844
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Dietary restriction in mice beginning at 1 year of age: Effects on serum immune complex levels (1982)
    Springer
    Age 5 (1982), S. 111-112 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One year old mice from a long-lived strain were gradually subjected to life-prolonging dietary restriction. Serum immune complex and immunoglobulin G (abbreviated IgG) levels were measured at 13 and 23 months of age. Longitudinal and cross-sectional analyses showed reduced serum immune complex and IgG levels for mice underfed in adulthood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431272
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Effect of dietary restriction upon the age-associated decline of lymphocyte DNA repair activity in mice (1988)
    Springer
    Age 11 (1988), S. 48-52 
    Details
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of dietary restriction (DR) on DNA repair capacity of mouse splenocytes after ultraviolet (UV)-induced damage were assessed. Two mouse cohorts received restricted amounts of purified hypocaloric diets; one was minimally restricted (∼75% of the caloric intake of mice fed a commercial diet ad libitum), the other was severely restricted (∼50% caloric restriction). An inverse correlation between age and DNA repair was present in the two cohorts; however, the regression lines of the two cohorts showed different slopes. DR appears to decelerate the age-associated decline of DNA repair capacity, and this delay might account in part for the improved immune function shown by old mice on DR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431772
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...