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  • Springer  (20)
  • 1
    Electronic Resource
    Electronic Resource
    Involvement of α-adrenoceptors in the excitatory effect of the A2 adenosine receptors agonist 5′-N-ethylcarboxamidoadenosine (NECA) on cardiac automaticity in the isolated right ventricle of the rat (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 350 (1994), S. 632-637 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac automaticity ; Adenosine receptors ; α-adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the non-selective A2 adenosine receptor agonist 5′-N-ethyl-carboxamidoadenosine (NECA) were studied on ventricular automaticity induced by a local injury in the isolated right ventricle of the rat. In concentrations ranging from 0.1 to 100 nM, NECA significantly increased ventricular automaticity. This effect was not apparent when the nonselective α-adrenoceptor blocker phenoxybenzamine was present at a concentration of 10 μM, which antagonizes both α1-and α2-adrenoceptors, as well as when rats were pretreated with reserpine. In non-reserpinized rats, the excitatory effect of NECA was also abolished in the presence of the selective α1-adrenoceptor antagonist prazosin, but not in the presence of the α2-adrenoceptor antagonist idazoxan. In reserpinized rats, the excitatory effect of NECA was restored in the presence of the non specific α-adrenoceptor agonist phenylephrine as well as in the presence of the selective α1-adrenoceptor agonist amidephrine but not in the presence of the selective α2-adrenoceptor agonist clonidine. These results suggest that the excitatory effect of NECA on ectopic ventricular automaticity is dependent on endogenous catecholamines and that α-adrenoceptors of type 1 are, in some way, involved in this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169368
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  • 2
    Electronic Resource
    Electronic Resource
    A follow-up electrophysiological study of rats with poor intrauterine fetal growth: the development of visual evoked responses (VERs) (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 724-726 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of some electrophysiological activities of the visual system (VERs) was compared in control rats and in young rats with poor intrauterine fetal growth caused by an electrolytic lesion of the placenta. Treated rats showed a delayed development of the electrophysiological functions considered, thus confirming the postnatal effect of poor intrauterine fetal growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967946
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  • 3
    Electronic Resource
    Electronic Resource
    Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma: local therapeutic effect and long-term survival rate (1998)
    Springer
    European radiology 8 (1998), S. 439-444 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Alcohol ; Liver neoplasms ; Liver neoplasms ; therapy ; Liver ; interventional procedure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of our study was to investigate local therapeutic effects and long-term results of combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in the treatment of large hepatocellular carcinoma (HCC). Eight-six patients (67 males and 19 females, age range 48–75 years, mean age 65.1 years) with Child-Pugh class A (n = 48) or B (n = 38) liver cirrhosis and a large HCC (main tumor 3.1–8 cm in diameter with no more than two daughter nodules) were enrolled in a prospective study. All patients underwent a single TACE session followed by PEI. Follow-up ranged from 4 to 65 months (mean 27.8 months, median 26 months). No major complication occurred. The local therapeutic effect, as assessed on the basis of findings at CT and MR imaging, was complete response in 71 of 86 patients (82 %) and partial response in 15 of 86. Overall survival rates by the Kaplan-Meier method were 92 % at 1 year, 83 % at 2 years, 69 % at 3 years, 58 % at 4 years, and 47 % at 5 years. Survival of Child-Pugh A patients (75 % at 3 years and 59 % at 5 years) was significantly longer (p 〈 0.01) than that of Child-Pugh B patients (61 % at 3 years and 35 % at 5 years). Combined TACE and PEI is an effective treatment for large HCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050409
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  • 4
    Electronic Resource
    Electronic Resource
    Inflammatory aneurysm of the abdominal aorta: role of ultrasonography (1993)
    Springer
    European radiology 3 (1993), S. 333-336 
    Details
    ISSN: 1432-1084
    Keywords: Aneurysm ; Aorta ; Inflammatory aneurysm ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During a 5-year period 229 aneurysms of the abdominal aorta were identified by ultrasonography (US) and subsequently submitted to CT. Of these, 41 were seen to be of the inflammatory type on the grounds of the CT scans, confirmed in 29 cases by surgical findings. The patients were 38 men and 3 women, mean age 64.9 years. US, performed using both 3.5 and 5 MHz probes, revealed the inflammatory nature of the aneurysm in 33 of 41 cases (80.5%). In the remaining cases a correct diagnosis could not be determined because of obesity and/or the distal location of the lesion. Regarding the complications associated with the inflammatory nature of the aneurysm (considered only in those cases submitted to surgery) US revealed a good diagnostic accuracy for ureteral involvement (7/7 cases detected, no false positives). Caval involvement was also correctly identified in 6 of 8 cases, although overestimated in 3 of 21. Both of these complications were correctly detected by CT in all cases. Neither US nor CT furnished reliable signs regarding duodenal and colonic involvement (surgically proven in 4 of 29 cases). US proved effective in detecting the inflammatory nature of the aneurysm. If surgery is considered, CT seems mandatory for a correct assessment of the complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167463
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrasonography of gastrointestinal tract disorders: retrospective and prospective evaluation (1995)
    Springer
    European radiology 5 (1995), S. 347-353 
    Details
    ISSN: 1432-1084
    Keywords: Gastrointestinal tract ; Gastrointestinal tract, inflammation ; Gastrointestinal tract, neoplasms ; Ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a retrospective analysis performed on 4167 routine abdominal sonographic (US) examinations (September 1989 to December 1991), 93 US reports strongly suggesting the presence of gastrointestinal (GI) tract disorders were found. Neoplastic GI tract diseases were indicated in 65.6 % of cases and non-neoplastic conditions in 34.4 %. The final diagnoses confirmed all the cases of non-neoplastic disease, while 3 patients sonographically suspected as having a neoplasm proved not to have any GI tract abnormality. In the period January 1992 to December 1992, 62 patients with a suspected GI tract abnormality were enrolled in a prospective double-masked US study after being submitted to conventional radiological studies only in 28 of 62 cases, after conventional studies and CT in 24 of 62 cases, and after CT only in 10 of 62 cases. Sonography furnished additional diagnostic information in 28 of 62 cases when the previous radiological examination did not include CT, but sonography misinterpreted 4 inflammatory disorders as tumours. Our study confirmed the important role of US alone or in association with other imaging modalities in the study of GI tract diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184942
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  • 6
    Electronic Resource
    Electronic Resource
    Differentiation of hepatocellular adenoma and focal nodular hyperplasia of the liver: comparison of power Doppler imaging and conventional color Doppler sonography (1997)
    Springer
    European radiology 7 (1997), S. 1410-1415 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Liver ; focal nodular hyperplasia ; Liver neoplasms ; diagnosis ; US ; Ultrasound ; Doppler studies ; power Doppler studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of our study was to compare the diagnostic efficacy of power Doppler imaging and conventional color Doppler sonography for differentiating between hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) of the liver. Thirty-one focal liver lesions (in 29 patients) with histologic proof of HCA (n = 9) or FNH (n = 22) were studied with power and color Doppler sonography according to a standardized examination protocol. The size of the lesions ranged between 1.5 and 14.5 cm (HCA, 3.5–14.5 cm, mean ± SD 7.3 ± 3.3 cm; FNH, 1.5–9.1 cm, mean ± SD 5.1 ± 2.1 cm). Intratumoral vessels with a venous Doppler spectrum, associated with either pulsatile or continuous peripheral flow, were detected in HCA (eight of nine lesions by power Doppler imaging and six of nine by color Doppler imaging) but not in FNH. In contrast, color signals with an arterial Doppler spectrum, radiating from the center to the periphery of the lesion, were depicted in FNH (20 of 22 cases by power Doppler imaging and 15 of 22 by color Doppler sonography) but not in HCA. Differentiation of HCA and FNH was achieved in 28 of 31 cases (90 %) by power Doppler imaging and in 21 of 31 (68 %) by color Doppler sonography (p 〈 0.01). Power Doppler imaging is superior to conventional color Doppler sonography in the depiction of the intratumoral flow characteristics of HCA and FNH, and enables a more accurate differential diagnosis than color Doppler sonography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050308
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  • 7
    Electronic Resource
    Electronic Resource
    Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: a European experience (1997)
    Springer
    European radiology 7 (1997), S. 514-519 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Alcohol ; Liver neoplasms ; Therapy ; Interventional procedure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objective of our work was to evaluate the long-term results of percutaneous ethanol injection (PEI) for the treatment of hepatocellular carcinoma (HCC) in patients with liver cirrhosis. A total of 184 cirrhotic patients with HCC underwent PEI as the only anticancer treatment over an 8-year period. Patients were followed after therapy by means of clinical examinations, laboratory tests, and US and CT studies performed at regular time intervals. Survival rates were determined according to the Kaplan-Meier method. The overall survival was 67 % at 3 years, 41 % at 5 years, and 19 % at 7 years. The 3-, 5-, and 7-year survival rates of patients with single HCC ≤ 3 cm (78, 54, and 28 %, respectively) were significantly higher (p 〈 0.01) than those of patients with single HCC of 3.1–5 cm (61, 32, and 16, respectively) or multiple HCCs (51, 21, and 0 %, respectively). Survival of Child-Pugh A patients (79 % at 3 years, 53 % at 5 years, and 32 % at 7 years) was significantly longer (p 〈 0.01) than that of Child-Pugh B patients (50 % at 3 years, 28 % at 5 years, and 8 % at 7 years). A selected group of 70 patients with Child-Pugh A cirrhosis and single HCC ≤ 3 cm had a 7-year survival of 42 %. Long-term survival of cirrhotic patients with HCC treated with PEI is comparable to that reported in published series of matched patients submitted to surgical resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050194
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  • 8
    Electronic Resource
    Electronic Resource
    Intrahepatic metastatic nodules of hepatocellular carcinoma detected at Lipiodol-CT: imaging-pathologic correlation (1997)
    Springer
    Abdominal imaging 22 (1997), S. 253 -258 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Contrast media, fatty acid—Lipiodol, hepatic intraarterial—Liver neoplasms, angiography—Liver neoplasms, CT—Liver neoplasms, diagnosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The purpose of this study was to determine whether tiny (〈2 cm) areas of iodized-oil retention diagnosed as intrahepatic metastatic nodules of hepatocellular carcinoma (HCC) at computed tomography (CT) following intraarterial injection of Lipiodol (Lipiodol-CT) correlate with truly cancerous foci on the corresponding sectioned pathologic specimens. Methods: Thirty-two consecutive patients with biopsy-proven HCC (26 men and six women, aged 41–72 years) underwent prospective evaluation with Lipiodol-CT before undergoing surgery (hepatic resection, 30 patients; liver transplantation, two patients). Imaging findings were correlated with intraoperative and pathologic findings. Results: Twenty-one areas of retained Lipiodol (0.5–1.6 cm in diameter, mean ± SD: 0.9 ± 0.3 cm) had features consistent with intrahepatic metastatic nodules of HCC on Lipiodol-CT scans. Nineteen of the 21 areas correlated with tumor deposits at pathologic examination of the surgical specimens, whereas two of 21 were due to abnormal retention of iodized oil within noncancerous liver parenchyma. The positive predictive value of findings at Lipiodol-CT for the diagnosis of intrahepatic metastatic nodule of HCC was 90.5%. Conclusions: Findings at Lipiodol-CT enable a reliable diagnosis of intrahepatic metastatic nodules of HCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900183
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  • 9
    Electronic Resource
    Electronic Resource
    Involvement of α-adrenoceptors in the excitatory effect of the A2 adenosine receptors agonist 5′-N-ethylcarboxamidoadenosine (NECA) on cardiac automaticity in the isolated right ventricle of the rat (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 350 (1994), S. 632-637 
    Details
    ISSN: 1432-1912
    Keywords: Key words: Cardiac automaticity – Adenosine receptors –α-adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effects of the non-selective A2 adenosine receptor agonist 5′-N-ethyl-carboxamidoadenosine (NECA) were studied on ventricular automaticity induced by a local injury in the isolated right ventricle of the rat. In concentrations ranging from 0.1 to 100 nM, NECA significantly increased ventricular automaticity. This effect was not apparent when the nonselective α-adrenoceptor blocker phenoxybenzamine was present at a concentration of 10 μM, which antagonizes both α1- and α2-adrenoceptors, as well as when rats were pretreated with reserpine. In non-reserpinized rats, the excitatory effect of NECA was also abolished in the presence of the selective α1-adrenoceptor antagonist prazosin, but not in the presence of the α2-adrenoceptor antagonist idazoxan. In reserpinized rats, the excitatory effect of NECA was restored in the presence of the non specific α-adrenoceptor agonist phenylephrine as well as in the presence of the selective α1-adrenoceptor agonist amidephrine but not in the presence of the selective α2-adrenoceptor agonist clonidine. These results suggest that the excitatory effect of NECA on ectopic ventricular automaticity is dependent on endogenous catecholamines and that α-adrenoceptors of type 1 are, in some way, involved in this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169368
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  • 10
    Electronic Resource
    Electronic Resource
    Commentary and remarks from Italy (1999)
    Springer
    Emergency radiology 6 (1999), S. 72-72 
    Details
    ISSN: 1438-1435
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101400050027
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