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  • 1
    Electronic Resource
    Electronic Resource
    Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA) in cancer patients (1983)
    Springer
    Cancer chemotherapy and pharmacology 11 (1983), S. 5-7 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The blood and urinary clearances of cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA, JM8) were determined in four patients with malignancy. A 40 μCi iv injection of 191Pt/193Pt (3:1)-labelled CBDCA was followed by serial blood and urine sampling to 72h. The blood clearance was triphasic, mean values for the fast, intermediate, and slow phases being 10.8 min, 2.5 h, and 125 h, respectively. The fraction of activity excreted in the urine within the first 6 h had a mean value of 66.7%, contrasting with 26.4% for cisplatin. There was only a small fraction of CBDCA excreted by the slow phase (1.5%) as against an average of 20% for CHIP and 27% for cisplatin. The early and rapid renal clearance of CBDCA may account for reduced nephrotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257407
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo distribution studies of radioactively labelled platinum complexes; cis-dichlorodiammine platinum(II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV), cis-dichloro-bis-cyclopropylamine platinum(II), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) in patients with malignant disease, using a gamma camera (1985)
    Springer
    Cancer chemotherapy and pharmacology 14 (1985), S. 253-257 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The in vivo distribution in man of the four platinum derivatives cis-dichlorodiammine platinum(II) (DDP), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV) (CHIP), cis-dichloro-bis-cyclopropylamine platinum (II) (CP), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) (CBDCA) has been observed. The availability of these compounds labelled with the radioactive isotope of platinum, platinum-191, has made serial in vivo imaging of their distribution possible. Injection of 17–35 MBq (5–28 mg) of the labelled compound IV was followed by imaging, using a gamma camera, with particular reference to the kidneys, liver, and tumour site. Hepatic and renal clearances were observed in all nine patients, but no unequivocal evidence of tumour uptake was found. The left kidney uptake was estimated at times up to 7 days after injection. Mathematical analysis of some of the uptake curves failed to show any significant difference between the clearance times observed. However, the two patients who received CBDCA did show a higher initial renal uptake, falling within the 1st day to levels comparable with those of the other compounds, and the three patients who received DDP showed consistently liver uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258128
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man (1981)
    Springer
    Psychopharmacology 75 (1981), S. 158-164 
    Details
    ISSN: 1432-2072
    Keywords: Tetrahydrocannabinol ; Pharmacodynamics ; Hysteresis plots ; Tachycardia ; Intoxication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between each of two pharmacologic effects (tachycardia and psychological “high”) of delta-9-tetrahydrocannabinol (THC) and plasma THC concentration was investigated in three male and three female experienced marihuana smokers. Each subject smoked one 1% THC cigarette on two occasions separated by 2 h. Heart rate and subjective psychological self-rating were determined frequently throughout the 4 h study period. Data were analyzed by calculating the area under the parameter versus time curves, constructing hysteresis plots, and calculating the decay rate constants from pharmacologic effect versus time plots. In both males and females, dose inhaled and psychological response were apparently equivalent for the first and second cigarettes. While all subjects exhibited marked tachycardia in response to the first cigarette, heart rate in both male and female subjects was not increased as markedly during the second cigarette. Interestingly, female subjects had less tachycardiac response than males during the second cigarette. Hysteresis plots revealed that both heart rate and subjective psychological effects were elicited in an effect compartment which was “deep” relative to the reference plasma compartment. The time courses of tachycardiac and psychological responses lagged behind the plasma THC concentration-time profile. Zero-order decay rate constants for subjective psychological rating did not change substantially from the first to second cigarette. This study suggests that plasma THC concentration is a poor predictor of simultaneously occurring physiological and psychological pharmacologic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432179
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  • 4
    Electronic Resource
    Electronic Resource
    Exercise Testing of the Child with Obesity (1999)
    Springer
    Pediatric cardiology 20 (1999), S. 79-83 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Children — Obesity — Exercise testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. As the prevalence of childhood obesity increases, exercise testing of obese children is likely to increase as well. This article discusses the implications of pediatric obesity for exercise testing and provides some recommendations for conducting tests and evaluating results. Studies comparing obese and nonobese children during exercise testing indicate that obese children are capable of meeting the challenges of exercise testing to nearly the same extent as their nonobese peers. Their physiologic responses, at least for the levels of obesity reported in the literature, are not sufficiently different from their nonobese counterparts to necessitate major changes in test protocols. Laboratory staff should pay special attention to fostering confidence in the obese child during the pretest routine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900405
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  • 5
    Electronic Resource
    Electronic Resource
    Taxonomic and functional implications of stigma morphology in species ofCassia, Chamaecrista, andSenna (Leguminosae:Caesalpinioideae) (1989)
    Springer
    Plant systematics and evolution 163 (1989), S. 93-105 
    Details
    ISSN: 1615-6110
    Keywords: Angiosperms ; Leguminosae (Fabaceae) ; Caesalpinioideae (Caesalpiniaceae) ; Cassia ; Chamaecrista ; Senna ; Stigma morphology ; taxonomy ; floral ecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two stigma forms occur inChamaecrista andSenna, but only one inCassia. In the common chambered form, a stigma pore is positioned on the reflexed style tip and is the entrance to a tapering chamber. The pore rim is fringed by hairs which vary in number, size, distribution and shape. In the alternative form the stigma is situated at the apex of the curved style and is crateriform. The crater rim is fringed by hairs of variable number and shape. The stigmatic hairs are predominantly unicellular and cutinized. Stigma and hair differences aid in the taxonomy of the genera. Their functions in pollination biology are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00936157
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  • 6
    Electronic Resource
    Electronic Resource
    Embryology and breeding systems inCrocus (Iridaceae)—a study in causes of chromosome variation (1984)
    Springer
    Plant systematics and evolution 148 (1984), S. 119-134 
    Details
    ISSN: 1615-6110
    Keywords: Angiosperms ; Iridaceae ; Crocus ; C. speciosus ; Embryo sac ; intraspecific hybrids ; chromosome numbers ; karyotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A detailed description of female reproductive structures inCrocus is given, using three different techniques: wax embedding and sectioning, SEM, and observation of cleared ovules by interference contrast microscopy. The results of this examination, and a chromosomal investigation of the intraspecific hybrids obtained by crossing specimens ofC. speciosus of different karyotypes, are used to test the hypothesis thatCrocus is apomictic. Although facultative diplospory cannot be entirely ruled out, it is suggested that apomixis is an unlikely explanation from the unusual amount of chromosomal variation found in some species ofCrocus, and alternative causes are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00984573
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  • 7
    Electronic Resource
    Electronic Resource
    Self-incompatibility and the pollen-stigma interaction inTradescantia ohiensis rafin (1984)
    Springer
    Protoplasma 121 (1984), S. 209-213 
    Details
    ISSN: 1615-6102
    Keywords: Receptive site ; Self-incompatibility ; Stigma papillae ; Tradescantia ohiensis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Self-incompatibility (SI) is reported for an accession ofTradescantia ohiensis. Pollen tube inhibition is stigmatic. The stigma is wet and papillate, the papillr surface bearing conspicuous blebs particularly in the mid- and basal regions of the cell. A proteinaceous pellicle is present on the surface of the papillar cuticle. The penetration of the stains calcofluor white and alcian blue into the cell wall of fresh stigma papillae strongly indicates that the permeability of the papillae is greatest at the mid-region of the cell and not at the tip. When single pollen grains are attached to the tip of a papilla there is either no response at all or the pollen adheres to the papilla. When attached in the mid-region pollen adheres, and often germinates. It is concluded that the sites of pollen receptivity are the mid- and basal regions of the papular cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01282314
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  • 8
    Electronic Resource
    Electronic Resource
    A light and electron microscopic study of stigmas inAneilema andCommelina species (Commelinaceae) (1982)
    Springer
    Protoplasma 112 (1982), S. 26-36 
    Details
    ISSN: 1615-6102
    Keywords: Aneilema ; Commelina ; Cytochemistry ; Evolution ; Papillae ; Pollination ; Secretion ; Stigmas ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The stigmas of species inAneilema andCommelina are trifid and comprise elongate papillae. Progressive degeneration of papular cells is observed in stigmas from open flowers and at anthesis papillae may be moribund and collapsed. Fluid emanating from the hollow style flows onto the surface through ruptures in the cuticle at the interpapillar junctions into the interstices at maturity. This secretion stains positively for protein. Stigmas are of the “wet” type. The cuticle overlying the papillar cells is ridged and at the final stages prior to flowering this cuticle becomes detached from the underlying cellulosic wall. The sub-cuticular space so formed is filled with secretion. InAneilema species detachment of cuticle is at the papillar tip and along the lateral walls. InCommelina species the anticlinal walls of adjacent papillae are strongly attached for much of their length and thus detachment of cuticle is restricted to the papillar tip. The cell wall at the tip in both genera may proliferate forming a rudimentary transfer-cell type wall. The secretion is considered to be produced by the papillar cells. It is PAS positive but fails to stain for protein and in both the light and electron microscopes appears heterogenous. Pollen attachment, hydration, germination and early tube growth are very rapid following self-pollination, the pollen tubes entering the neck of the style within ten minutes of attachment. A unique character combination involving pollen and stigmas in these genera indicates a monophyletic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01280212
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetic study of smoking marijuana (1982)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 10 (1982), S. 495-506 
    Details
    ISSN: 1573-8744
    Keywords: marijuana ; THC ; smoking ; hysteresis loops ; pharmacokinetic-pharmacodynamic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Six subjects each smoked a 1% marijuana cigarette and 2 hr later smoked a second one. Plasma levels of delta-9-tetrahydrocannabinol were measured for 9 hr with a radioimmunoassay. Heart rate and self-reported “high” were measured for 2 hr after each cigarette. All three measures showed a rapid increase after the start of smoking with Cmax occurring before the end of smoking. There was a strong correlation between decrease in heart rate and plasma levels from 10 min after smoking until 120 min. All pharmacodynamic response measures returned to baseline values within approximately 2 hr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059033
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  • 10
    Electronic Resource
    Electronic Resource
    The magnetic phase diagram of La2−x Sr x CuQ4+y observed via111In PAC (1990)
    Springer
    Hyperfine interactions 61 (1990), S. 1067-1071 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report perturbed angular correlation studies of111In diffused into La2−x Sr x CuO4+y . We determine the Néel temperature, TN, as a function of x for y ≈ 0 and provide an empirical calibration of the charge defect concentration via the PAC linewidth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02407574
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