GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 46 (2000), S. 227-234 
    ISSN: 1432-0843
    Keywords: Key words ALIMTA ; Pemetrexed disodium ; Population pharmacokinetics ; NONMEM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To evaluate the population pharmacokinetics of pemetrexed disodium in cancer patients enrolled in four different open-label, multicenter, nonrandomized phase II studies. Methods: Pemetrexed disodium was administered as a 10-min intravenous infusion (600 mg/m2) every 21 days. A total of four blood samples were to be collected each cycle per patient (n=103 patients) during cycles 1 and 3. Plasma concentration-time data were analyzed by nonlinear mixed-effect modeling using NONMEM to estimate pemetrexed disodium pharmacokinetic parameters (mean, and between- and within-patient variability) as well as relationships between the pharmacokinetic parameters and various patient-specific factors (demographic and physiologic data). Results/Conclusions: The pharmacokinetics of pemetrexed disodium were best characterized by a two-compartment model with initial distribution and terminal elimination half-lives of 0.63 h and 2.73 h, respectively. The typical value of systemic clearance (CL) in liters per hour included a relationship to creatinine clearance (CrCL) with a slope of 0.0292. Typical values of central volume (Vc), distributional CL (Q), and peripheral volume (Vp) were 11.3 l, 3.21 l/h, and 5.20 l, respectively. Between-patient variability was 19.6%, 15.6%, and 21.7% for CL, Vc, and Vp, respectively. A combined additive/proportional error model was used to describe residual variability, with a coefficient of variation of 23.7% for the proportional component and a standard deviation of 0.0410 μg/ml for the additive component. Significant patient-specific factors on CL were calculated CrCL, body weight, and to a lesser extent alanine transaminase and folate deficiency. Gender and body weight were significant factors on Vc while both body surface area and albumin were significant factors on Vp. In conclusion, population pharmacokinetic modeling revealed relationships between pharmacokinetic parameters and various patient specific factors.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 28 (1995), S. 287-297 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Ninety-six-hour acute and 28-day larval survival and growth tests were conducted with nine organic chemicals, using the Japanese medaka (Oryzias latipes) as the test organism. The nine tested chemicals were allyl isothiocyanate, aniline, benzyl acetate, 4-chloroaniline, 2-chloroethanol, 2,4-diaminotoluene, 1,2-dibromoethane, 2,4-dichlorophenoxyacetic acid (2,4-D), and phenol. The derived 96-h LC50 values for medaka for all chemicals ranged from 0.077 mg/L for allyl isothiocyanate to 2,780 mg/L for 2,4-D. The chronic values for six of the nine chemicals tested ranged from 0.013 mg/L for allyl isothiocyanate to 42.5 mg/L for 2,4-D. Acute-to-chronic ratios for these six chemicals ranged from 1.4 for 2-chloroethanol to 70.9 for 2,4-D. Growth of medaka was significantly reduced in the lowest exposure concentration during 28-day larval tests with aniline, 4-chloroaniline, and 2,4-diaminotoluene. The estimated maximum acceptable toxicant concentration was reported as less than the lowest exposure concentration of 4.6, 2.2 and 40.3 mg/L for tests with aniline, 4-chloroaniline and 2,4-diaminotoluene, respectively. Chronic values for 2-chloroethanol and medaka were 12.6 mg/L during an embryo-larval test and 22.1 mg/L during the 28-day larval test.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 22 (1992), S. 384-388 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Previous work revealed substantial levels of mutagenicity in effluents from certain municipal wastewater treatment plants. One of these treatment plants was selected for further study to track the effluent mutagenicity to its sources, to chemically characterize the mutagenicity, and to assess the treatability of the mutagens. Mutagenicity testing using the Salmonella/microsome assay was performed on methylene chloride extracts of influent and effluent samples from the municipal wastewater treatment plant, as well as on four selected industrial effluents entering the plant. The mutagenicity of the influent samples was detected only in the presence of a microsomal metabolic activation system and was highest in Salmonella strain TA98. About two-thirds of the mutagenicity passed through the treatment plant, suggesting that the mutagenic compounds were refractory to conventional biological treatment. No significant mutagenic activity was detected in three of the industrial waste streams, all paper products plant discharges. However, a high level of mutagenicity (1.2 million TA98 revertants/liter) was detected in the effluent from a coke oven plant. This source could account for all of the mutagenicity entering the wastewater treatment plant. After fractionation of the coke oven effluent by sequential extraction at neutral, acidic and basic pH with methylene chloride, 93% of the TA98 (+S9) mutagenicity was found in the neutral fraction. A C18 column fractionation scheme using a methanol/water elution gradient revealed that 92% of the mutagenicity eluted with the 75% and the 80% methanol in water fractions. The C18 fractionation also provided good separation of mutagenicity from toxicity to fathead minnows. This study has demonstrated the potential of toxicity reduction evaluation (TRE) methodology for tracing effluent toxicity to its source, using genotoxicity as an endpoint.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1298-1299 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Chez le rat, les injections dedl-thréo-3,4-dihydroxyphénylsérine, un précurseur pharmacologique synthétique de la noradrénaline, provoquent une conversion de moins de 1% au 4-hydroxy-3-méthoxyphényl-glycol, le métabolite urinaire majeur de la noradrénaline dans cette espèce. Un nouveau cheminement qui entraîne une coupure latérale de la chaîne prit environ 10% de la dose et un autre 10% fût excrété comme un amino-acideO-méthylé; le sort de quelque 80% est inconnu.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the L-Dopa treated rat, a decreased urinary output of free and conjugated dopamine and an increase in free and conjugated L-Dopa excretion after administration of decarboxylase-inhibiting drugs provide a goodin vivo index of Dopa decarboxylase inhibition. With the exception of free dopamine output, which showed an equivocal change, these measurements appear to provide a good yardstick of decarboxylase status in man also. Using this approach, it was not possible to find any evidence of facilitation of decarboxylase action, in L-Dopa-treated parkinsonians given pyridoxine supplements, to account for the ability of this compound to neutralize the beneficial effect of L-Dopa.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1615-6102
    Keywords: In vitro shoots ; Pisum sativum ; Meristematic cells ; Shoot apices ; Transformation ; Agrobacterium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Different tissues in cultured pea shoots were inoculated withAgrobacterium tumefaciens wild types C 58 and ACH 5 andA. rhizogenes wild type 9402. The C 58 and 9402 bacteria induced the formation of tumours and hairy roots respectively while the ACH 5 was inactive. The younger the tissue the more rapidly it responded to the active bacteria. The shoot apex was the most reactive organ and developed into a tumour, theA. rhizogenes tumours subsequently giving rise to transformed hairy roots. Histological examination showed that transformed cells (including those within the apical dome) initially became highly vacuolate before dividing rapidly to form a tumour. These changes were accompanied by cell division in surrounding tissues.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...