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  • 1
    Electronic Resource
    Electronic Resource
    Inherited congenital normofunctional testicular hyperplasia and mental deficiency (1978)
    Springer
    Human genetics 〈Berlin〉 41 (1978), S. 331-339 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Three 46,XY unrelated individuals out of 84 postpubertal male inpatients with severe mental deficiency in a psychiatric hospital were found to have megalorchidia and macrogenitosomia. One of the cases had a similarly affected brother. Endocrine studies were performed in two of the cases with similar results. Normal plasma levels of pituitary gonadotropins were found. A normal testicular function was demonstrated by the finding of normal: (a) baseline plasma testosterone levels and a significant rise following human chorionic gonadotropin administration, (b) sperm analysis, and (c) morphology and cell architecture of the testes. These results were compatible with normofunctional testicular hyperplasia confirming previous observations and allowing the definite individualization of a syndrome with mental deficiency probably due to an X-linked recessive mutation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284767
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nerve Growth Factor Increases Sodium Current in Pancreatic β Cells (1996)
    Springer
    The journal of membrane biology 153 (1996), S. 53-58 
    Details
    ISSN: 1432-1424
    Keywords: Key words: NGF—Na channels—Pancreatic β-cells—cAMP—Reverse hemolytic plaque assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Nerve growth factor (NGF) induces neuritelike process outgrowth in cultured adult pancreatic β cells. DbcAMP partially mimics this effect on cell morphology, and both compounds act synergistically to promote neuritelike process outgrowth. To determine if NGF- and dbcAMP-induced differentiation was accompanied by changes in β cell electrical activity, we studied the macroscopic Na current of adult rat β cells identified with the reverse hemolytic plaque assay and cultured for one week with these factors. After 5–7 days, β cells cultured in the presence of 2.5S NGF exhibited a 48% increase on the macroscopic Na current, which was due to an increase on Na current density. We did not observe changes on voltage dependence of current activation, nor on steady-state inactivation. Although dbcAMP also promotes changes on β cell morphology, it did not affect the Na current density.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900109
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Interregional foodborne salmonellosis outbreak due to powdered infant formula contaminated with lactose-fermenting Salmonella virchow (1996)
    Springer
    European journal of epidemiology 12 (1996), S. 377-381 
    Details
    ISSN: 1573-7284
    Keywords: Foodborne-outbreak ; Powdered infant formula ; Salmonella virchow lactose +
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spain's Salmonella surveillance system backed by regionally-based epidemiologists around the country made it possible to detect and halt the spread of a foodborne salmonellosis outbreak due to powdered infant formula contaminated with a lactose-fermenting strain of Salmonella virchow. Forty-eight cases involving children, mostly under 7 months old, were detected in 14 out of Spain's 17 Regions. The outbreak started in January and ended in June 1994. All cases were microbiologically confirmed. The implicated strain had a 3.6 kb plasmid, was susceptible to all antimicrobials tested except nitrofurantoin and was phagetype 4a. Isolates from 8 of 24 Brand “A” milk samples tested had the same characteristics as case isolates. All affected/suspect batches of Brand “A” milk were destroyed and the product withdrawn from sale, which led to the end of the outbreak. This incident underscores the importance of maintaining surveillance systems able to detect and prevent foodborne outbreaks and alert to the possibility of isolating unusual lactose-fermenting Salmonella serotypes in especially sensitive food products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00145301
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    Paper (German National Licenses)
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