ISSN:
1573-7330
Keywords:
in vitro fertilization-embryo transfer
;
twin pregnancy
;
Duchenne muscular dystrophy
;
prenatal diagnosis
;
confined placental mosaicism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A twin pregnancy following in vitro ferilization-embryo transfer coincidentally at risk for the X-linked recessive Duchenne muscular dystrophy is described. Firsttrimester prenatal diagnosis by transabdominal chorionic villus samplings on the dichorionic placentae and molecular linkage analysis could exclude the disorder in both fetuses. Genetic counseling and prenatal diagnosis were particularly complex due to the twin pregnancy, the need for linkage analysis, and confined placental mosaicism 45,X/46XX in one of the fetuses. All parties should be aware that additional invasive diagnostic procedures in the second trimester might be required. It is proposed that, in similar situations, only one, arguably two, fertilized egg be transferred at a time to facilitate prenatal diagnosis and decision making for these rare couples. This problem, however, may be increasingly overcome by preimplantation diagnosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02332091
Permalink
