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  • 1
    Electronic Resource
    Electronic Resource
    Gradient-like structure and Morse decompositions for time-periodic one-dimensional parabolic equations (1995)
    Springer
    Journal of dynamics and differential equations 7 (1995), S. 73-107 
    Details
    ISSN: 1572-9222
    Keywords: Nonautonomous parabolic equations ; attractors ; gradient-like structure ; Morse decomposition ; recurrence ; zero number ; center manifolds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Scalar one-dimensional parabolic equations with periodically time-dependent nonlinearities are considered. For each such equation, the associated discretetime dynamical system is shown to admit Morse decompositions of the global attractor whose Morse sets are contained in a given, arbitrarily small neighborhood of the set of fixed points. Existence of such Morse decompositions implies that the chain recurrent set coincides with the set of fixed points. In particular, the dynamical system has a gradient-like structure. As an application of these results, a description of the asymptotic behavior of solutions of asymptotically periodic equations is given: Any bounded solution approaches a set of periodic solutions of the limiting equation. Other possible applications to nonlocal equations and thin domain problems are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02218815
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Temperature-controlled Radiofrequency Ablation of Cardiac Tissue: An In Vitro Study of the Impact of Electrode Orientation, Electrode Tissue Contact Pressure and External Convective Cooling (1999)
    Springer
    Journal of interventional cardiac electrophysiology 3 (1999), S. 257-262 
    Details
    ISSN: 1572-8595
    Keywords: radiofrequency ablation ; electrode contact ; lesion size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: A variety of basic factors such as electrode tip pressure, flow around the electrode and electrode orientation influence lesion size during radiofrequency ablation, but importantly is dependent on the chosen mode of ablation. However, only little information is available for the frequently used temperature-controlled mode. The purpose of the present experimental study was to evaluate the impact during temperature-controlled radiofrequency ablation of three basic factors regarding electrode-tissue contact and convective cooling on lesion size. Methods and Results: In vitro strips of porcine left ventricular myocardium were ablated in a tissue bath. Temperature-controlled ablation at 80 °C for 60 s was performed using a 7F 4 mm tip electrode in either perpendicular or parallel contact with the endocardium at a pressure of 10 or 20 g. Increased flow around the electrode was induced by circulating the saline in the tissue bath at a flow-velocity of 0.1 m/s. Lesion volume was determined by cutting lesions in 1 mm thick slices, staining with nitroblue tetrazolium and planimetering. A total of 107 lesions was created. Lesion size was significantly larger for perpendicular electrode orientation compared to parallel for both pressure-settings and both levels of flow around the electrode (p 〈 0.05). Increased flow around the electrode enlarged lesion size (p 〈 0.005). Electrode-tissue contact pressure had no significant impact on lesion size. Conclusions: During temperature-controlled radiofrequency ablation increased external cooling of the electrode tip due to either flow of the surrounding liquid or poor electrode tissue contact, as exemplified by perpendicular versus parallel electrode orientation, increases lesion size significantly. This is in contrast to the impact of these factors during power-controlled ablation due to the lack of increased power-delivery in the latter situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009864111507
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  • 3
    Electronic Resource
    Electronic Resource
    A strong unique continuation theorem for parabolic equations (1998)
    Springer
    Mathematische Annalen 311 (1998), S. 603-630 
    Details
    ISSN: 1432-1807
    Keywords: Mathematics Subject Classification (1991): 35Bxx, 35K40, 35R45, 28A78
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002080050202
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of Circulating Tumour DNA in the Blood (Plasma/Serum) of Cancer Patients (1999)
    Springer
    Cancer and metastasis reviews 18 (1999), S. 65-73 
    Details
    ISSN: 1573-7233
    Keywords: mutation detection ; microsatellite DNA ; circulating DNA ; cancer ; plasma/serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Small amounts of free DNA circulate in both healthy and diseased human plasma/serum, and increased concentrations of DNA are present in the plasma of cancer patients. Characteristics of tumour DNA have been found in genetic material extracted from the plasma of cancer patients. These features include decreased strand stability and the presence of specific oncogene, tumour suppressor gene and microsatellite alterations. Point mutations of the ras genes have been detected in the plasma DNA of patients suffering from haematopoetic malignancies, colorectal and pancreatic cancer, sometimes prior to clinical diagnosis. Rearranged immunoglobulin heavy chain DNA has been found in the plasma of patients with non-Hodgkins lymphoma and acute B cell leukaemia. Microsatellite instability, expressed either as a new allele or a loss of one allele (LOH) occurs in the plasma and serum DNA of patients suffering from head and neck, lung and renal cell cancer. The results obtained in many different cancers have opened a new research area indicating that plasma DNA might eventually be a suitable target for the development of non-invasive diagnostic, prognostic and follow-up tests for cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006260319913
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    Paper (German National Licenses)
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