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  • 1
    Electronic Resource
    Electronic Resource
    Positive Iliac and Obturator Nodes in Melanoma: Survival and Prognostic Factors (1999)
    Springer
    Annals of surgical oncology 6 (1999), S. 255-262 
    Details
    ISSN: 1534-4681
    Keywords: Groin dissection ; Survival ; Complications ; Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The need for deep groin dissection when superficial nodes contain metastatic melanoma is controversial. Methods: A review of 362 therapeutic groin dissections performed at our tertiary referral center between 1961 and 1995 revealed 71 patients (20%) with positive iliac and/or obturator nodes. This group was analyzed for survival rates, prognostic factors for survival, regional tumor control, and morbidity. Results: Patients with involved deep nodes exhibited overall 5-year and 10-year survival rates of 24% (SE, 5%) and 20% (SE, 5%), respectively. Independent prognostic factors for survival were the number of positive iliac nodes (P = .0011), the Breslow thickness (P = .0069), and the site of the primary tumor (P = .0075). Patients with an unknown primary tumor seemed to have better prognoses. Seven patients (10%) experienced recurrence in the surgically treated groin. The shortand long-term morbidity rates (infection, 17%; skin flap necrosis, 15%; seroma, 17%; mild/ moderate lymphedema, 19%; severe lymphedema, 6%) compared well with those of other series studying inguinal as well as ilioinguinal dissections. Conclusions: From the present study it can be concluded that removal of deep lymph node metastases is worthwhile, because one of every five such patients survives for 10 years. Prognostic factors for survival are the number of involved iliac nodes, the Breslow thickness, and the site of the primary tumor. Long-term regional tumor control can be obtained for 90% of the patients. The morbidity of an additional deep lymph node dissection is acceptable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-999-0255-5
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of 55-155-155-1in second order QCD from hadronicZ decays (1992)
    Springer
    The European physical journal 54 (1992), S. 55-73 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Distributions of event shape variables obtained from 120600 hadronicZ decays measured with the DELPHI detector are compared to the predictions of QCD based event generators. Values of the strong coupling constant αs are derived as a function of the renormalization scale from a quantitative analysis of eight hadronic distributions. The final result, αs(M Z), is based on second order perturbation theory and uses two hadronization corrections, one computed with a parton shower model and the other with a QCD matrix element model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01881708
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  • 3
    Electronic Resource
    Electronic Resource
    Measurement of the partial width of theZ 0 intob $$\bar b$$ final states using their semi-leptonic decays (1992)
    Springer
    The European physical journal 56 (1992), S. 47-61 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The spectra of prompt electrons and muons from the semi-leptonic decays of heavy hadrons produced inZ 0 decays have been used to measure the coupling of theZ 0 tob quarks weighted by theB hadrons mean semi-leptonic branching fraction, giving a value: $$BR_{sl}^b *{{\Gamma _{b\bar b} } \mathord{\left/ {\vphantom {{\Gamma _{b\bar b} } {\Gamma _H }}} \right. \kern-\nulldelimiterspace} {\Gamma _H }} = 0.0221 \pm 0.0015$$ . The data has also been used to measure the value of the fragmentation parameter, defined in the context of the LUND PS Model, version 7.2, giving: $$\varepsilon (b) = \left( {8\begin{array}{*{20}c} { + 5} \\ { - 3} \\ \end{array} \pm 2} \right)10^{ - 3} $$ . The corresponding value of the mean fraction of the beam energy taken by aB hadron in the fragmentation of ab quark is: $$\overline {X_E^b } = 0.69\begin{array}{*{20}c} { + 0.02} \\ { - 0.03} \\ \end{array} \pm 0.01$$ . If the values of $$\Gamma _{b\bar b} $$ andΓ H are taken from the Standard Model, the following value is obtained for the mean semi-leptonic braching fraction ofB hadrons: BR sl b =(10.1±0.7)%. Taking the value of $${{\Gamma _{b\bar b} } \mathord{\left/ {\vphantom {{\Gamma _{b\bar b} } {\Gamma _{\rm H} }}} \right. \kern-\nulldelimiterspace} {\Gamma _{\rm H} }}$$ from an independent analysis of DELPHI data based on the use of the boosted sphericity product, a value: BR sl b =(10.1±1.3)% is obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01589706
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  • 4
    Electronic Resource
    Electronic Resource
    A study of the decays of tau leptons produced on theZ resonance at LEP (1992)
    Springer
    The European physical journal 55 (1992), S. 555-567 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract From the analysis of a data sample corresponding to an integrated luminosity of 4.63 pb−1 taken during the 1990 run of LEP at centre of mass energies between 88.2 GeV an 94.2 GeV, the tau decays $$\tau ^ - \to e^ - \bar v_e v_\tau ,\tau ^ - \to \mu ^ - \bar v_\mu v_\tau ,\tau ^ - \to \pi ^ - (K^ - )v_\tau ,\tau ^ - \to \rho {}^ - v_\tau $$ and their charge conjugates have been studied. The following branching ratios have been measured; $$BR(\tau ^ - \to e^ - \bar v_e v_\tau ) = 18.6 \pm 0.8(stat.) \pm 0.6(sys.)\% ,$$ , $$BR\left( {\tau ^ - \to \mu ^ - \bar v_\mu v_\tau } \right) = 17.4 \pm 0.7 \pm 0.6\% ,$$ , Br(τ− → π− (K−)vτ)=11.9±0.7±0.7%, BR (τ− → ρ− vτ)= 22.4±0.8±1.3%, in good agreement with world averages. The measured electronic and muonic branching ratios lead to a measurement of the strong coupling constant, αs (mτ) = 0.26 −0.12 +0.09 . Extrapolating the αs value fromm τ tom Z yields αs (mZ) = 0.109 −0.028 +0.012 . The average polarizationP τ of taus produced in Z → τs τs decays has also been measured using the above decay modes. The weighted mean of the polarizations obtained from the four decay modes isP τ=−0.24±0.07. This value ofP τ gives, in the improved Born approximation, a ratio between the axial and vector coupling constants of the tau of υτ/aτ = 0.12 ± 0.04, and hence a value of the effective electroweak mixing parameter sin2 θW(m Z 2 ).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561293
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  • 5
    Electronic Resource
    Electronic Resource
    Charged particle multiplicity distributions for fixed number of jets inZ 0 hadronic decays (1992)
    Springer
    The European physical journal 56 (1992), S. 63-75 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The multiplicity distributions of charged particles in full phase space and in restricted rapidity intervals for events with a fixed number of jets measured by the DELPHI detector are presented. The data are well reproduced by the Lund Parton Shower model and can also be well described by fitted negative binomial distributions. The properties of these distributions in terms of the clan model are discussed. In symmetric 3-jet events the candidate gluon jet is found not to be significantly different in average multiplicity than the mean of the other two jets, thus supporting previous results of the HRS and OPAL experiments. Similar results hold for events generated according to the LUND PS and to the HERWIG models, when the jets are defined by the JADE jet finding algorithm. The method seems to be insensitive for measuring the color charge ratio between gluons and quarks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01589707
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  • 6
    Electronic Resource
    Electronic Resource
    Measurement of the triple-gluon vertex from 4-jet events at LEP (1993)
    Springer
    The European physical journal 59 (1993), S. 357-368 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract From the combined data of 1990 and 1991 of the DELPHI experiment at LEP, 13057 4-jet events are obtained and used for determining the contribution of the triple-gluon vertex. The relevant variables are the generalized Nachtmann Reiter angle θ NR * and the opening angle of the two least energetic jets. A fit to their two-dimensional distribution yields $$C_A /C_F = 2.12 \pm 0.35 and N_C /N_A = 0.46 \pm 0.19,$$ whereC A/C F is the ratio of the coupling strength of the triple-gluon vertex to that of gluon bremsstrahlung from quarks, andN C/N A, the ratio of the number of quark colours to the number of gluons. This constitutes a convincing model-independent proof of the existence of the triple-gluon vertex, since its contribution is directly proportional toC A/C F. The results are in agreement with the values expected from QCD:C A/C F=2.25, andN C/N A=3/8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01498617
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  • 7
    Electronic Resource
    Electronic Resource
    Determination ofα s using the next-to-leading-log approximation of QCD (1993)
    Springer
    The European physical journal 59 (1993), S. 21-33 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new measurement of αs is obtained from the distributions in thrust, heavy jet mass, energy-energy correlation and two recently introduced jet broadening variables following a method proposed by Catani, Trentadue, Turnock and Webber. This method includes the full calculation ofO( s 2 ) terms and leading and next-to-leading logarithms resummed to all orders of αs. The analysis is based on data taken with the DELPHI detector at LEP during 1991. I its found that the inclusion of the resummed leading and next-to-leading logarithms reduces the scale dependence of αs and allows an extension of the fit range towards the infrared limit of the kinematical range. The combined value for αs obtained at the scale μ2=M Z 2 is: $$\alpha _s (M_Z^2 ) = 0.123 \pm 0.006.$$
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01555835
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  • 8
    Electronic Resource
    Electronic Resource
    Separation of multiple genes controlling the T-cell proliferative response to IL-2 and anti-CD3 using recombinant congenic strains (1995)
    Springer
    Immunogenetics 41 (1995), S. 301-311 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract T lymphocytes of the strain BALB/cHeA exhibit a low proliferative response to IL-2 and a high response to the anti-CD3 monoclonal antibodies, while the strain STS/A lymphocyte response to these stimuli is the opposite. We analyzed the genetic basis of this strain difference, using a novel genetic tool: the recombinant congenic strains (RCS). Twenty BALB/c-c-STS/Dem (CcS/Dem) RCS were used, each containing a different random set of approximately 12.5% of the genes from STS and the remainder from BALB/c. Consequently, the genes participating in the multigenic control of a phenotypic difference between BALB/c and STS become separated into different CcS strains where they can be studied individually. The strain distribution patterns of the proliferative responses to IL-2 and anti-CD3 in the CcS strains are different, showing that different genes are involved. The large differences between individual CcS strains in response to IL-2 or anti-CD3 indicate that both reactions are controlled by a limited number of genes with a relatively large effect. The high proliferative response to IL-2 is a dominant characteristic. It is not caused by a larger major cell subset size, nor by a higher level of IL-2R expression. The response to anti-CD3 is known to be controlled by polymorphism in Fcγ receptor 2 (Fcgr2) and the CcS strains carrying the low responder Fcgr2 allele indeed responded weakly. However, as these strains do respond to immobilized anti-CD3, while the STS strain does not, and as some CcS strains with the BALB/c allele of Fcgr2 are also low responders, additional gene(s) of the STS strain strongly depress the anti-CD3 response. In a backcross between the high responder and the low responder strains CcS-9 and CcS-11, one of these unknown genes was mapped to the chromosome 10 near D10Mit14. The CcS mouse strains which carry the STS alleles of genes controlling the proliferative response to IL-2 and anti-CD3 allow the future mapping, cloning, and functional analysis of these genes and the study of their biological effects in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172155
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  • 9
    Electronic Resource
    Electronic Resource
    Genetic control of T-cell proliferative response in mice linked to chromosomes 11 and 15 (1996)
    Springer
    Immunogenetics 44 (1996), S. 475-477 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050155
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  • 10
    Electronic Resource
    Electronic Resource
    On the mechanism of alpha-receptor mediated modulation of 3H-noradrenaline release from slices of rat brain neocortex (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 299 (1977), S. 115-122 
    Details
    ISSN: 1432-1912
    Keywords: Cerebral cortex ; Noradrenaline release ; Presynaptic α-receptors ; Calcium ions ; Hyperpolarization ; Tetrodotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain cortical slices were superfused with Krebs-Ringer media and the effects of oxymetazoline (an α-adrenoceptor agonist) and phentolamine (an α-antagonist) on depolarization-induced 3H-NA release were examined. Depolarization was effected by various K+-concentrations or by electrical pulses. The effects of the α-receptor agents on stimulated 3H-NA overflow appeared to be dependent on the strength of the depolarizing stimulus. Thus, at low K+-concentrations (13 or 26 mM) oxymetazoline decreased and phentolamine increased the stimulated overflow, while at 56 mM K+ little or no modulation was found. The agents acting on α-receptors modulated 3H-NA release in a dose-dependent way (5 · 10−8–10−5 M). The lack of modulation by oxymetazoline of 3H-NA release induced by 56 mM K+ seems not to be due to a high concentration of NA released into the synaptic cleft, since reduction of the endogenous NA level by pretreatment with α-methyl-para-tyrosine did not reveal such modulation. However, oxymetazoline was found to decrease 56 mM K+-induced 3H-NA release effectively, if the Ca2+-concentration in the medium was lowered from 1.2 to 0.2 mM. This suggests that α-receptor mediated modulation of release may occur as a result of a change in Ca2+-availability to the depolarization-secretion process. In addition, hyperpolarization of nerve endings might be involved in the modulatory process, as concluded from calculations of the (theoretical) trans-membrane potential at various K+-concentrations. Although the α-receptors modulating NA release seem to be localized presynaptically, their precise location remains uncertain. Experiments with tetrodotoxin suggested that the α-receptor mediated modulation does not operate via a local interneuronal loop.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498553
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