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  • 1
    Electronic Resource
    Electronic Resource
    Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 681-686 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Li-Fraumeni syndrome (LFS) is characterized by a high risk of sarcomas, early onset of breast cancer, and a diversity of other cancers occurring as multiple primary tumors in multiple family members. In many families with LFS, germline mutations within the tumor-suppressor gene p53 have been identified. However, mutations in p53 have not been detected in approximately 30% of LFS families. To address the possibility either that p53 mutations were being missed or that another predisposing gene is altered in LFS, we used a variety of methods to accurately determine the p53 status in a large LFS kindred. A transcriptional activation assay on exons 4–10 of p53 excluded a mutation within the DNA-binding domain of p53. Single-stranded conformational-polymorphism analysis, using intronic primers and sequencing of all the coding exons and intron/exon junctions, also yielded no mutations. Finally, linkage analysis excluded potential mutations in the noncoding regions of p53. Our findings exclude the presence of a p53 germline mutation in a classic LFS family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050761
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of a comprehensive type a measure for children in a biracial community: The Bogalusa heart study (1987)
    Springer
    Journal of behavioral medicine 10 (1987), S. 425-439 
    Details
    ISSN: 1573-3521
    Keywords: Type A behavior ; children ; coronary-prone behavior ; age ; race ; gender
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract To evaluate the development of Type A-like behavior in children, responses to the Hunter-Wolf Instrument were studied in 2128 children in Bogalusa, Louisiana, a biracial community. Test-retest reliability measures were generated by retesting a random subsample of 387 children 2 weeks after the initial testing. Norms were tabulated for each of the age, race, and sex groups. Increases in total and subscale scores with age were noted except for the Hostility subscale, which decreased dramatically in the older groups. White males had higher average scores during the entire period than other groups and scored significantly higher than other groups on subscales, created from principal-components analysis, measuring Eagerness and Hostility. Low test-retest correlations were observed in children younger than 13 years of age. Of the four race-sex groups studied, white males appear to accrue the highest risk for coronary heart disease from type A-like behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00846142
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  • 3
    Electronic Resource
    Electronic Resource
    Cigarette smoking, alcohol, and oral contraceptive use by Type A adolescent—The Bogalusa heart study (1989)
    Springer
    Journal of behavioral medicine 12 (1989), S. 13-24 
    Details
    ISSN: 1573-3521
    Keywords: Type A ; smoking ; alcohol ; contraception ; adolescents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Type A behavior pattern (TABP) is an independent risk factor for cardiovascular (CV) disease and is characterized by hostile, aggressive, competitive behavior. TABP characteristics and CV risk factors have been found in children and adolescents. TABP has been correlated with adult alcohol consumption, but studies associating Type A and smoking are mixed. The purpose of this study is to investigate the smoking, alcohol use, and oral contraceptive use of Type A children and adolescents. The Hunter-Wolf Type A scale and a health habits questionnaire were evaluated for 2092 children, ages 8–17 years, within the context of a comprehensive biracial epidemiological CV screening in Bogalusa, Louisiana. Global Type A and factor components were evaluated: hostility, eagergy, desire for control, drive, and competitiveness. Correlation coefficients reflected the strongest associations between hostility and smoking and between hostility and drinking for white males. The age at menarche appeared to be correlated with the drive component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00844746
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    Paper (German National Licenses)
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