ISSN:
1573-2568
Keywords:
celiac disease
;
soluble adhesion molecules
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Adhesive interactions between endothelium and circulating cells are crucial for the development of inflammatory reactions. We found significantly higher serum levels of soluble intracellular adhesion molecule-1 (sICAM-1, 492.5 ± 22.1 ng/ml) in patients with active celiac disease (including IgA-deficient patients) than in patients on a gluten-free diet (335.7 ± 20.0 ng/ml) (P 〈 0.001) and healthy controls (207.4 ± 11.2 ng/ml) (P 〈 0.001). The concentration of soluble E-selectin in sera from celiac patients (37.2 ± 3.4 ng/ml) was also higher (P 〈 0.001) than in sera from healthy controls (15.5 ± 0.7 ng/ml) but, in contrast to sICAM-1, it remained high in the patients after treatment (30.2 ± 2.7 ng/ml). Interestingly, the concentration of circulating soluble interleukin-2 receptors, molecules indicating lymphocyte activation, was only increased in sera from patients with active celiac disease (2943.0 ± 214.1 pg/ml), and the level in sera from treated patients and healthy controls was comparable (1936 ± 349 and 1416 ± 111.7 pg/ml). The elevated serum level of soluble cell adhesion molecules could be used as a supplementary, noninvasive procedure for monitoring intestinal immune reactions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005489316037
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