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  • lipolysis  (2)
  • Springer  (2)
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  • Springer  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Failure of glucagon to stimulate ketone body production during acute insulin deficiency or insulin replacement in man (1982)
    Springer
    Diabetologia 23 (1982), S. 94-100 
    Details
    ISSN: 1432-0428
    Keywords: Ketone body turnover ; ketogenesis ; acetone ; lipolysis ; insulin ; diabetes ; glucagon ; somatostatin ; non-esterified fatty acids ; glycerol ; glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the role of glucagon and insulin in the acute regulation of ketone body kinetics in man, somatostatin was administered with various combinations of these hormones by replacement infusions in groups of six to seven normal subjects. Somatostatin-induced insulin and glucagon deficiency produced a threefold increase in total ketone body concentrations within 2 h. This increase was the combined result of enhanced production (71%), and decreased metabolic clearance (32%), as determined by14C-acetoacetate infusions. An associated elevation of non-esterified fatty acids (66%) and glycerol levels occurred. Glucagon replacement (2 ng · kg-1 · min-1) during insulin deficiency failed to enhance ketogenesis or lipolysis but lowered theβ-hydroxybutyrate/acetoacetate concentration ratios. Hyperglycaemia, observed during glucagon administration and insulin deficiency, did not diminish ketone body production or lipolysis. In contrast, insulin replacement (150 μU · kg-1 · min-1) diminished lipolysis, lowered ketone production, and elevated the metabolic clearance rate of ketone bodies. Glucagon infusions (2 and 4 ng · kg-1 · min-1) during somatostatin and insulin replacement did not accelerate ketone body production or raise non-esterified fatty acid levels, but produced a dose-dependent elevation of blood glucose levels. The results suggest that glucagon is not an important ketogenic hormone under the conditions studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271167
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of insulin on ketone body clearance studied by a ketone body “clamp” technique in normal man (1988)
    Springer
    Diabetologia 31 (1988), S. 24-29 
    Details
    ISSN: 1432-0428
    Keywords: Ketone bodies ; ketone body clearance ; β-hydroxybutyrate ; acetoacetate ; ketogenesis ; ketoacidosis ; insulin ; lipolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of elevated plasma insulin concentration (55±2 mU/l) on peripheral clearance and production of total ketone bodies was determined using 3-14C-acetoacetate tracer infusions. Nine normal subjects were studied twice, once during insulin infusion (20 mU·m−2·min−1), once during basal plasma insulin concentrations (controls). Blood total ketone body concentrations (sum of acetone, acetoacetate and β-hydroxybutyrate) were maintained in both studies at 2 mmol/l by feedback-controlled sodium acetoacetate infusions. The coefficient of variation of total ketone body concentrations during the two clamp studies was 10 and 11% respectively. The sodium acetoacetate infusion rate required during the clamp was 55±4% higher during hyperinsulinaemia than in controls (p〈0.005). This was due to increased total ketone body clearance (8.4±0.7 vs 6.7±0.4 ml·kg−1· min−1, p〈0.015), and to enhanced suppression of ketone body production (p〈0.01). Hyperketonaemia alone decreased ketone body production by 42% and diminished ketone body clearance by 46%, the former being enhanced, the latter being in part antagonised by insulin. Since the plasma insulin concentrations were within those observed in patients treated for diabetic ketoacidosis, the data suggest that the antiketotic effect of insulin therapy results in part from an increase in peripheral ketone body disposal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279128
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    Paper (German National Licenses)
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