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  • L-DOPA  (2)
  • Springer  (2)
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  • Springer  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of coadministration of glutamate receptor antagonists and dopaminergic agonists on locomotion in monoamine-depleted rats (1995)
    Springer
    Journal of neural transmission 10 (1995), S. 27-39 
    Details
    ISSN: 1435-1463
    Keywords: Locomotion ; monoamine-depletion ; reserpine ; α-methyl-p-tyrosine ; (+)-MK-801 ; NBQX ; SKF 38393 ; SKF 82958 ; dihydrexidine ; bromocriptine ; L-DOPA ; rats ; D1 receptor agonists ; D2 receptor agonist ; NMDA receptor antagonist ; AMPA receptor antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combinations of dopaminergic agonists with glutamate receptor antagonists have been suggested to be a possible alternative treatment of Parkinson's disease. To gain further insights into this possibility, the antagonist of the competitive AMPA-type glutamate receptor NBQX and the ion-channel blocker of the NMDA glutamate receptor (+)-MK-801 in combination with the dopamine D1 receptor agonists: SKF 38393, SKF 82958 and dihydrexidine; the dopamine D2 receptor agonist bromocriptine and the dopamine-precursor L-DOPA were tested in rats pretreated with reserpine and α-methyl-p-tyrosine. MK-801 on its own induced locomotor behaviour and potentiated the antiakinetic effects of dihydrexidine and L-DOPA but not of the other dopamine agonists tested. NBQX neither on its own nor coadministered with the dopamine agonists tested had an antiakinetic effect. These results indicate that agents, blocking the ion-channel of the NMDA receptor, might be useful adjuvants to some but not all dopaminomimetics in therapy of Parkinson's disease. The same does not seem to be true for the AMPA-antagonist NBQX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02256627
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    6-Hydroxydopamine lesion of locus coeruleus and the antiparkinsonian potential of NMDA-receptor antagonists in rats (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 363-377 
    Details
    ISSN: 1435-1463
    Keywords: Noradrenaline ; locus coeruleus ; 6-OHDA lesion ; NMDA receptor-antagonists ; L-DOPA ; Parkinson's disease ; open field ; locomotion ; exploration ; behavior ; rat ; HPLC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Behavioral and neurochemical effects after bilateral 6-hydroxy-dopamine locus coeruleus- (LC) lesion were examined in rats and compared to sham-lesioned controls. Behavior after treatment with the antiakinetic drugs dizocilpine, amantadine, memantine or L-DOPA as well as joint treatment of these drugs with haloperidol were tested in an open field with holeboard and in an experimental chamber. Under saline spontaneous activity (open field with holeboard) and sniffing (experimental chamber) were reduced after lesion. Injection of the proparkinsonian drug haloperidol decreased sniffing in all rats but to a greater extent in LC-lesioned rats. In combination with haloperidol none of the tested drugs could completely compensate for the motor deficits induced by the lesion. Neurochemical data revealed a reduced content of noradrenaline in the prefrontal cortex and in the posterior striatum of LC-lesioned rats. These results indicate that loss of LC neurons intensifies parkinsonian symptoms induced by blockade of dopamine D2-receptors, and lowers the antiakinetic potential of dizocilpine, amantadine, memantine or L-DOPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277657
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    Paper (German National Licenses)
    Fulltext
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