ISSN:
1432-1246
Keywords:
Lead in blood
;
ALA-U
;
FEP
;
ZPP
;
Dose-effect relationships
;
Prediction of PbB
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In about 100 workers from a secondary smelter, lead in whole blood (PbB), 5-aminolevulinic acid in urine (ALA-U) and porphyrins in whole blood (using various methods) were determined. Comparability in the dose-effect relationship between PbB and ALA-U in this experiment with literature results was bad, but was better for PbB and the porphyrins. The best predictor for lead in blood was, of course, PbB itself, followed by the porphyrins. The porphyrin level can be used as a predictor in 1. monitoring groups of workers 2. as a rough indicator of PbB (error 100 μg/1 or 0.48 μol/1) in individual workers with moderate to high levels of lead exposure (say 400–1000 μg/1 or 1.9–5 [mol/l). The ALA-U determination should be made more specific and accurate, while the porphyrin determination should be standardized. A possible procedure for standardizing a porphyrin-meter is given.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01274136
Permalink
