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  • Cobalt (iron) complexes  (1)
  • IL-1a  (1)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Cobalt (iron) thiolato complexes containing the Co-ligand phosphine and reaction products of the structural fragment ML 2 L′ (L = 1,2-bidentate thiolate,L′= tertiary phosphine) (1996)
    Springer
    Journal of cluster science 7 (1996), S. 317-340 
    Details
    ISSN: 1572-8862
    Keywords: Cobalt (iron) complexes ; thiolate ; phosphine ; structure ; synergism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Mono-, di-, tri-, and tetra-nuclear cobalt (iron) complexes containing co-ligands phosphine and thiolate are presented according to the classification by combination of different dentates of the two ligands. Emphasis is being put on the triand tetranuclear cluster complexes of monodentate phosphines and 1,2-bidentate thiolates. These complexes are considered to be constructed based on the general structural fragment (or building block) ML 2L′ (L=1,2-bidentate thiolate,L′=tertiary phosphine). Structural regularities are presented in Tables I, III, IV, and V and discussed. FAB mass spectroscopic data showed the possible fragmentation patterns. Synergism of the cluster skeletons is proposed to explain the occurrence of the distinct structural modes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01171186
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  • 2
    Electronic Resource
    Electronic Resource
    The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC (1998)
    Springer
    Clinical & experimental metastasis 16 (1998), S. 655-664 
    Details
    ISSN: 1573-7276
    Keywords: proinflammatory cytokines ; IL-1a ; IL-6 ; IL-8 and GM-CSF ; squamous cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human and murine squamous cell carcinomas (SCC) have been reported to produce proinflammatory cytokines IL-1a, IL-6, GM-CSF, and IL-8 or KC. Production of individual members of the proinflammatory cytokine family has been associated with increased tumor growth or metastasis in a variety of neoplasms. In this study, we determined whether the expression of these cytokines occurs as a result of the events of cel-lular transformation or culture, or is promoted by interaction of neoplastic cells with factors or cells in the host environment. We compared the expression of proinflammatory cytokines following the spontaneous transformation of murine keratinocytes in vitro, and following the formation of tumors and metastases from these transformed keratinocytes in syngeneic recipients in vivo. Using sensitive ELISA assays, we found that cultures of the in vitro transformed Balb/c SCC line Pam 212 do not produce elevated levels of proinflam-matory cytokines IL-1a, IL-6, GM-CSF and KC, indicating that transformation or culture alone is insufficient to account for the level of cytokine expression detected in patient and experimental tumors. In contrast, Pam reisolates from primary and metastatic tumors were obtained which constitutively produce markedly elevated levels of cytokines IL-1a, IL-6, KC and GM-CSF. The increase in the expression of these cytokines by SCC in vivo occurred independent of T and B lymphocyte-mediated immunity, since increases in expression of the cytokines was observed in lines reisolated from immunodeficient athymic nude and SCID Balb/c congenic mice. The increased expression of cytokines appeared to result from additional events in vivo, rather than due to selection of a pre-existing cytokine-producing subpopulation, since clones of the parental cell line expressed lower cytokine levels than cloned reisolates, and clones of the non-secreting parental cell line that formed tumors in vivo secreted elevated levels of cytokines following reisolation. We conclude that the development of SCC that express proinflammatory cytokines is promoted by tumor-host interaction(s) that are independent of specific T and B cell immunity©Lippincott Williams & Wilkins
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006559811429
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