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  • Aspirin  (1)
  • Dungeness crabs  (1)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 412 (1987), S. 119-125 
    ISSN: 1432-2307
    Keywords: 16,16-dimethyl prostaglandin E2 ; Aspirin ; Tight junctions ; Stomach ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The canine gastric epithelium was exposed to solutions containing 20 mM aspirin and 20 mM aspirin + 30 µg/kg 16,16-dimethyl prostaglandin E2 (dmPGE2) for periods of three and forty minutes. No macroscopic hemorrhagic lesions were seen. Light microscopically, surface lesions were reduced from 10 percent (aspirin alone) to 2.5% (aspirin+dmPGE2). However, dmPGE2 does not appear to attenuate aspirin induced tight junction alterations. Discontinuities in the apical occluding complexes, hyperplastic tight junctions and stand number variability were documented in freeze frature replicas of aspirin as well as aspirin+ dmPGE2 treated dog stomachs. The results of these experiments would seem to suggest that 30 µg/kg dmPGE2 does not prevent aspirin induced damage to the tight junctions of the canine gastric epithelium or enhance their repair.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Hydrobiologia 269-270 (1993), S. 197-205 
    ISSN: 1573-5117
    Keywords: Pseudonitzschia ; domoic acid ; amnesic shellfish poisoning ; razor clams ; Dungeness crabs ; N.E. Pacific Ocean
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Members of the planktonic diatom genus Pseudonitzschia H. Peragallo, P. pungens (Grun.) Hasle f. multiseries (Hasle) Hasle and P. australis Frenguelli, that may produce the marine biotoxin, domoic acid, have been recognized in western Washington waters. Their distribution is not well-known in this area, probably because they often have been misidentified. However, they appear to be relatively common and may be abundant, especially in late spring and summer. Domoic acid, a potent neurotoxin, was found at levels up to 154 µg g−1 wet weight in razor clams, Siliqua patula Dixon, and Dungeness crabs, Cancer magister Dana, on the Pacific coast of Washington in late October 1991. It was also found in trace amounts in blue mussels, Mytilus edulis L., and oysters, Crassostrea gigas Thun., in the inland waters of northern Puget Sound in summer 1992. The presence of these potentially toxic diatoms signals the need for regular phytoplankton monitoring and additional shellfish monitoring to ensure that seafood is safe for human consumption. Further, studies are needed on the physiological ecology of the diatoms to determine the causative factors leading to production of the toxin.
    Type of Medium: Electronic Resource
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