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  • 3-Vinylindoles  (1)
  • Altered phenotypes  (1)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    [a]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity (1996)
    Springer
    Monatshefte für Chemie 127 (1996), S. 97-102 
    Details
    ISSN: 1434-4475
    Keywords: 3-Vinylindoles ; Carbazoles ; Diels-Alder reactions ; Cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die aus den methoxysubstituierten 3-Vinylindolen1 und2 zugänglichen Cycloaddukte3,5 und7 lassen sich mitDDQ zu den coplanar-anellierten Carbazolen4,6 und8 dehydrieren. Verbindung4a, die auch durch eine Röntǵenstrukturanalyse charakterisiert wurde, zeigt signifikante Cytotoxizität gegen Humantumor-Zellinien (K562 und RXF93).
    Notes: Summary The cycloadducts3,5, and7, readily available from methoxy-substituted 3-vinylindoles1 and2, were dehydrogenated withDDQ to the coplanar [a]-anellated carbazoles4,6, and8. Compound4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807414
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  • 2
    Electronic Resource
    Electronic Resource
    Heterogeneous alterations of UDP-glucuronosyltransferases in mouse hepatic foci (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 285-289 
    Details
    ISSN: 1432-1335
    Keywords: Mouse hepatic foci ; Altered phenotypes ; UDP-glucuronosyltransferase ; Glucuose-6-phosphatase ; N-nitrosomorpholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary UDP-glucuronosyltransferase (UDPGT) was studied immunohistochemically in hepatic foci and nodules of N-nitrosomorpholine-treated mice. Serial sections were stained for glucose-6-phosphatase (G6Pase). It was found that a high percentage of G6Pase-negative liver foci and nodules were also UDPGT-negative (34%). In addition, G6Pase-negative foci without altered UDPGT phenotype (30%) and UDPGT-negative foci without altered G6Pase phenotype (8%) were detected. G6Pase-positive foci were also present (24%). Interestingly, most G6Pasepositive foci were UDPGT-positive (16%). Some G6Pase-positive lesions without altered UDPGT phenotype were also found (8%). The major phenotype observed in rat hepatocarcinogenesis models (UDPGT-positive/G6Pase-negative foci) was not detectable in the mouse model. These results demonstrate heterogeneous alterations of UDPGTs in mouse hepatic foci. They furthermore suggest marked differences between the mouse and the rat in the regulation of UDPGTs in similarly induced rat hepatic foci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391704
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    Paper (German National Licenses)
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