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  • Recovery  (3)
  • Mood  (2)
  • 1,3-Butanediol  (1)
  • Springer  (6)
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  • Springer  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man (1976)
    Springer
    Pflügers Archiv 367 (1976), S. 137-142 
    Details
    ISSN: 1432-2013
    Keywords: Man ; Muscle ; Exercise ; Recovery ; Phosphorylcreatine ; Phosphagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The time course of phosphorylcreatine (PC) resynthesis in the human m. quadriceps femoris was studied during recovery from exhaustive dynamic exercise and from isometric contraction sustained to fatigue. The immediate postexercise muscle PC content after either form of exercise was 15–16% of the resting muscle content. The time course of PC resynthesis during recovery was biphasic exhibiting a fast and a slow recovery component. The half-time for the fast component was 21–22 s but this accounted for a smaller fraction of the total PC restored during recovery from the isometric contraction than after the dynamic exercise. The half-time for the slow component was in each case more than 170 s. After 2 and 4 min recovery the total amounts of PC resynthesized after the isometric exercise were significantly lower than from the dynamic exercise. Occlusion of the circulation to the quadriceps completely abolished the resynthesis of PC. Restoration of resynthesis occurred only after release of occlusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585149
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glycolytic intermediates in human muscle after isometric contraction (1981)
    Springer
    Pflügers Archiv 389 (1981), S. 277-282 
    Details
    ISSN: 1432-2013
    Keywords: Lactate ; Glycogenolysis ; Muscle contraction ; Glycogen ; Human muscle ; Recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isometric contraction of the quadriceps muscle sustained to fatigue with a force of 66% of the maximum voluntary contraction force resulted in a mean glycogen utilization of 80.4 (S.D. 58.4) mmol glucosyl units/kg dry muscle (d.m.) and an accumulation of glycolytic intermediates and glucose corresponding to 82.9 (S.D. 17.5) mmol glucosyl units/kg d.m. Accumulation of hexose phosphates (principally glucose 6-phosphate) accounted for 35.4% (S.D. 4.1) of the total increase and lactate for 59.3% (S.D. 2.8). During a 4 min recovery period glucose 6-[hosphate content showed a linear decrease with a half time of 2.0 min and lactate decreased exponentially with a half time of 2.5 min. The rate of lactate disappearance from the muscle was approximately 4 times as fast as that observed previously after maximal bicycle exercise. This was probably due to a lower lactate concentration in blood after isometric contraction resulting in a larger muscle-blood gradient for lactate. Muscle content of free glucose was increased after contraction and increased further during recovery. It is concluded that the glucose increase is confined to the intracellular pool and is an effect of hexokinase inhibition by accumulated glucose 6-phosphate. Occlusion, of the local circulation after the contraction inhibited the recovery processes for lactate and glucose 6-phosphate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584790
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of caffeine or diphenhydramine on visual vigilance (1994)
    Springer
    Psychopharmacology 114 (1994), S. 233-238 
    Details
    ISSN: 1432-2072
    Keywords: Vigilance ; Response time ; Caffeine ; Diphenhydramine ; Human performance ; Visual perception ; Mood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of two drugs having opposite effects on the central nervous system were investigated using a newly developed visual vigilance task. Twenty-four male volunteers (median age=20) performed the task on three separate occasions; after consuming placebo, caffeine (200 mg), or diphenhydramine (25 mg), in a double-blind, Latin Square design. At least 2 days intervened between drug administrations. Caffeine use was restricted for 10 h and smoking for 3 h before drug administration. When compared with placebo, caffeine significantly increased the number of correct responses and decreased response times, whereas diphenhydramine decreased the number of correct responses and increased response times. Low habitual consumers of caffeine (〈 100 mg/day) and non-smokers had more correct responses than did high habitual caffeine consumers (〉 100 mg/day) and smokers, but only in the placebo condition. Non-smokers had faster response times than smokers only in the placebo condition. Both caffeine and diphenhydramine altered certain aspects of mood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244842
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of pharmacological daytime doses of melatonin on human mood and performance (1993)
    Springer
    Psychopharmacology 112 (1993), S. 490-496 
    Details
    ISSN: 1432-2072
    Keywords: Human ; Melatonin ; Mood ; Performance ; Reaction time ; Vigilance ; Fatigue ; Circadian ; Sleep ; Alertness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Melatonin (10, 20, 40, or 80 mg, PO) or placebo was administered at 1145 hours on five separate occasions to 20 healthy male volunteers and the effects on serum melatonin levels, mood, performance, and oral temperature were monitored. Subjects were studied between 0930 and 1700 hours. A battery of interactive computer tasks designed to assess performance and mood was completed, oral temperature was measured, and blood samples were taken for serum melatonin radioimmunoassay. The areas under the time-melatonin concentration curve (AUC) varied significantly in proportion to the various melatonin doses. Compared with placebo treatment, all melatonin doses significantly decreased oral temperature, number of correct responses in auditory vigilance, response latency in reaction time, and self-reported vigor. Melatonin also increased self-reported fatigue, confusion, and sleepiness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244899
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  • 5
    Electronic Resource
    Electronic Resource
    Impairment of avoidance behavior following short-term ingestion of alcohol (1979)
    Springer
    Psychopharmacology 63 (1979), S. 251-257 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; 1,3-Butanediol ; Avoidance behavior ; Ethanol withdrawal syndrome ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acquisition and retention of a shock avoidance task were impaired in mice at 5h and 5 days but not at 14 days after withdrawal from 5 days of chronic alcohol consumption. Mice trained before ingestion of an alcohol-containing diet showed impairment in retention of the shock avoidance procedure 5 h after withdrawal from the diet but not during ingestion or 5 days after withdrawal. At 5 h after withdrawal from the alcohol-containing diet, motor activity and sensitivity to shock were not affected, but there was a decreased motor response to shock. There was no correlation between performance of the avoidance task and the severity of withdrawal signs, as measured by hypothermia or convulsions on handling. The hypothermia and other withdrawal signs were reversed. by acute injection of alcohol but the impairment in avoidance responding was not. These results demonstrate that consumption of an ethanol-containing diet for periods as short as 5 days results in relatively long-lasting alterations in avoidance behavior after withdrawal of the diet. This behavioral impairment appears to be distinct from other signs of alcohol withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433558
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Lactate content and pH in muscle samples obtained after dynamic exercise (1976)
    Springer
    Pflügers Archiv 367 (1976), S. 143-149 
    Details
    ISSN: 1432-2013
    Keywords: Hydrogen ion ; Lactate ; Pyruvate ; Exertion ; Muscle ; Blood ; Man ; Recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Analyzes were made on muscle samples taken from the lateral part of the m. quadriceps femoris of man (lactate, pyruvate, and pH) on venous blood (lactate, pyruvate) and on capillary blood (pH). Samples were taken at rest, immediately after termination of dynamic exercise and during 20 min recovery from exhaustive dynamic exercise. Muscle pH decreased from 7.08 at rest to 6.60 at exhaustion. Decrease in muscle pH was linearly related to muscle content of lactate + pyruvate. The relationship was slightly different from what has been obtained after isometric exercise and this difference was ascribed to acid-base exchange with the blood during dynamic exercise. Lactate content was highly elevated in muscle after exercise and the concentration was 2–3 times higher than in blood. Pyruvate content was, however, only slightly higher than that at rest. During recovery lactate content of muscle decreased exponentially with respect to time, whereas pyruvate content increased. The half-time of lactate decrease was 9.5 min. From the lactate dehydrogenase equilibrium relative values on NADH/NAD ratio could be calculated. It was found that NADH/NAD was highly increased after exercise and that it had not returned to the basal value after 20 min recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585150
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    Paper (German National Licenses)
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