ISSN:
1432-0584
Keywords:
Key words Thalassemia
;
Chelation
;
Desferrioxamine
;
Allergy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In some patients compliance to subcutaneous desferrioxamine therapy is reduced because of allergic symptoms. Effective drug desensitization consists of bringing patients to tolerate the same mode of administration. We evaluated three thalassemic patients with severe allergies to desferrioxamine. Each patient received weekly three prefilled infusors with desferrioxamine 4 g/48 m1/48 h for s.c. therapy. Follow-up was performed for 12 consecutive weeks. During follow-up no allergic events were noted. The s-ferritin levels decreased from 2583 μg/l±485 to 1916 μg/l±275 (mean decrease 25.8%, p=0.038). Compliance to the infusional system was excellent. Our results show that continuous infusion of desferrioxamine using a new infusional delivery system is effective in preventing allergic reactions and in reducing iron overload.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050241
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