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  • Springer  (4)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 13 (1975), S. 436-442 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-3254
    Keywords: Thailand ; HIV risk behavior ; commercial sex ; injection drug use
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Correlates of behavior associated with HIV exposure risk were evaluated in cross-sectional data from 3,839 Royal Thai Army (RTA) recruits whose birthplaces and residences were located away from Thailand's main HIV epicenter. Participants were generally 21 years old, unmarried, educated at the primary school level, and previously had been engaged in agriculture or unskilled labor. HIV prevalence in the sample was 1.8%. Condom use with commercial sex workers (CSW) was less than universal, and a small subset of men emerged who had multiple categories of partners. Nonetheless, CSW patronage appeared lower than in early studies in the Thai epicenter of the Upper North, and the venues patronized generally were not low-cost, high-turnover brothels. Sexual experience with girlfriends was more frequent than CSW experience, and the rate of condom use with girlfriends was relatively low. Lifetime injection drug use (IDU) was reported by 4.1% of the total sample and was associated with recent urban residence, CSW patronage, and sexual precocity. Findings suggest gaps in Thailand's condom campaign and the need to better address HIV risk associated with having multiple partners.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-3521
    Keywords: anxiety ; blood pressure ; chemotherapy ; distraction ; nausea ; relaxation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Sixty cancer chemotherapy patients were randomly assigned to one of six conditions formed by a 3(cognitive distraction, relaxation training, no intervention)×2(high anxiety, low anxiety) factorial design. All patients were followed for five consecutive chemotherapy sessions. Outcome measures included patient reports, nurse observations, and physiological indices. Results indicated that distraction patients reported less nausea prior to chemotherapy and lower systolic blood pressures after chemotherapy than controls. Relaxation training patients reported less nausea prior to chemotherapy and exhibited lower systolic and diastolic blood pressures after chemotherapy than control patients. There were no significant differences between distraction and relaxation training patients on any measure. Patients with high initial levels of anxiety exhibited continually elevated levels of distress throughout the chemotherapy experience; however, anxiety level did not interact with the effectiveness of the treatment interventions. Overall, the data support the use of both cognitive distraction and relaxation training for reducing the distress of chemotherapy with both high and low-anxiety patients and suggest that at least some of the effects of relaxation training can be achieved with distraction alone.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Child psychiatry & human development 2 (1971), S. 26-31 
    ISSN: 1573-3327
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ninety-four pairs of retarded children, in one of whom hyperactivity was rated as no problem and in the other as a severe problem, were matched for age and year of examination. The findings indicated a higher incidence of central nervous system damage and/or dysfunction in the hyperactive children than in those who were not hyperactive. Of six cases of hemiplegia, all were in the hyperactive group as were seven of eight cases of diplegia. A significantly larger portion of the hyperactive group had a history of convulsive seizures, and significantly more had a residual speech defect. The hyperactive children had lower social quotients than those not hyperactive, and a greater number of them were not yet completely toilet trained for both bowel and bladder control. The hyperactive children showed a significantly higher incidence of destructiveness, of withdrawal, of assaultiveness, and of overanxiousness and fearfulness than those not hyperactive. Possible relations of these behaviors were discussed. Severe hyperactivity affects quite unfavorably the prognosis for the behavioral adjustment of a retarded child.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2018-01-06
    Description: Congestive heart failure typically arises from cardiac myocyte necrosis/apoptosis, associated with the pathological opening of the mitochondrial permeability transition pore (mPTP). mPTP opening decreases the mitochondrial membrane potential leading to the activation of Ca2+-independent phospholipase A2γ (iPLA2γ) and the production of downstream toxic metabolites. However, the array of enzymatic mediators and the exact chemical mechanisms responsible for modulating myocardial mPTP opening remain unclear. Herein, we demonstrate that human heart failure activates specific myocardial mitochondrial phospholipases that increase Ca2+-dependent production of toxic hydroxyeicosatetraenoic acids (HETEs) and attenuate the activity of phospholipases that promote the synthesis of protective epoxyeicosatrienoic acids (EETs). Mechanistically, HETEs activated the Ca2+-induced opening of the mPTP in failing human myocardium, and the highly selective pharmacological blockade of either iPLA2γ or lipoxygenases attenuated mPTP opening in failing hearts. In contrast, pharmacological inhibition of cytochrome P450 epoxygenases opened the myocardial mPTP in human heart mitochondria. Remarkably, the major mitochondrial phospholipase responsible for Ca2+-activated release of arachidonic acid (AA) in mitochondria from non-failing hearts was calcium-dependent phospholipase A2ζ (cPLA2ζ) identified by sequential column chromatographies and activity-based protein profiling. In contrast, iPLA2γ predominated in failing human myocardium. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2ζ metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2γ activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. This remodeling metabolically channels AA into toxic HETEs promoting mPTP opening, which induces necrosis/apoptosis leading to further progression of heart failure.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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