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  • Society of Pharmaceutical Tecnocrats  (2)
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  • Society of Pharmaceutical Tecnocrats  (2)
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  • 1
    Online Resource
    Online Resource
    Design and Evaluation of Chitosan films for Transdermal delivery of Glimepiride
    Society of Pharmaceutical Tecnocrats ; 2018
    In:  International Journal of Innovative Science & Technology ( 2018-12-09), p. 13-25
    Details
    In: International Journal of Innovative Science & Technology, Society of Pharmaceutical Tecnocrats, ( 2018-12-09), p. 13-25
    Abstract: Glimepiride is a third generation oral antidiabetic sulphonylurea drug frequently prescribed to patients of type 2 diabetes. However, its oral therapy is encountered with bioavailability problems due to its poor solubility leading to irreproducible clinical response, in addition to adverse effects like dizziness and gastric disturbances. As a potential for convenient, safe and effective antidiabetic therapy, the rationale of this study was to develop a transdermal delivery system for glimepiride. Chitosan polymer was utilized in developing transdermal films for glimepiride. Chitosan has film forming ability, bioadhesive and absorption enhancing properties. Aiming at optimizing the drug delivery and circumventing the skin barrier function, inclusion complexation of glimepiride with beta-cyclodextrin (β-CyD) as well as the use of several conventional penetration enhancers were monitored for augmenting the drug flux. The physical and mechanical properties of the prepared films were investigated using tensile testing, IR spectroscopy and X-ray diffractometry. Release studies revealed adequate release rates from chitosan films. Permeation studies through full thickness rat abdominal skin were conducted. High flux values were obtained from films comprising a combination of the drug with limonene and ethanol as well as from films containing glimepiride-β-CyD complex. In vivo studies on diabetic rats for selected formulae revealed a marked therapeutic efficacy sustained for about 48 hours. The above-mentioned results shed light on feasibility of utilizing chitosan as an effective, safe transdermal delivery system for glimepiride characterized by increased patient compliance and better control of the disease.
    Type of Medium: Online Resource
    ISSN: 2455-9946
    URL: Article
    DOI: 10.22270/ijist.v3i4.19
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2018
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    Online Resource
  • 2
    Online Resource
    Online Resource
    FORMULATION AND EVALUATION OF MATRIX TRANSDERMAL PATCHES OF GLIBENCLAMIDE
    Society of Pharmaceutical Tecnocrats ; 2018
    In:  Journal of Drug Delivery and Therapeutics Vol. 8, No. 5-s ( 2018-10-01), p. 366-371
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 8, No. 5-s ( 2018-10-01), p. 366-371
    Abstract: The present study deals with the formulation and evaluation of transdermal patches of Glibenclamide towards enhance its permeation through the skin and maintain the plasma level concentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and iso-propylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Among the formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observed for the formulations F12 and F4 i.e. 80.012 ± 2.012 % and 98.365±3.012% respectively. The mechanism of drug release was found to be Non-Fickian diffusion controlled. FT-IR studies revealed the integrity of the drug in the formulations. Keywords: Transdermal Patches, Glibenclamide, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v8i5-s.1993
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2018
    detail.hit.zdb_id: 2767921-4
    SSG: 15,3
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