In:
Clinical Management Issues, Seed SRL, Vol. 4, No. 5S ( 2015-10-13), p. 9-13
Abstract:
We report a case of patient with chronic myeloid leukemia who started imatinib at standard dose and obtained a sub-optimal response at 6 months. Considering the patient as a possible “late responder”, we decided not to change the imatinib dose, but, at 12 months, we did not achieve a complete cytogenetic response. At that time, we decided to switch to a second-generation tyrosine kinase inhibitor (TKI), nilotinib 800 mg/day, obtaining soon a major molecular response. Recently, the retrospective application of European LeukemiaNet guidelines in large cohorts of patients suggested that patients whose response to imatinib is sub-optimal at 6 months showed significantly worse survival. Therefore we can hypothesise that this kind of patients could be eligible for an early switch to second-generation TKI.
Type of Medium:
Online Resource
ISSN:
2283-3137
,
1973-4832
DOI:
10.7175/cmi.v4i5S.1092
Language:
Unknown
Publisher:
Seed SRL
Publication Date:
2015
detail.hit.zdb_id:
2744441-7
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