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  • 1
    Online Resource
    Online Resource
    Genetic Variability and Correlation Studies for Pre-harvest Sprouting Tolerance and Associated Traits in Soybean [Glycine max L. Merrill.]
    Sciencedomain International ; 2021
    In:  Current Journal of Applied Science and Technology ( 2021-03-27), p. 1-10
    Details
    In: Current Journal of Applied Science and Technology, Sciencedomain International, ( 2021-03-27), p. 1-10
    Abstract: Evaluation of a set of 65 diverse genotypes of soybean was carried out for their pre-harvest sprouting (PHS) tolerance in a field study during kharif 2019. Percentage of pods ruptured by sprouting seed (PPR) was used as a measure of pre-harvest sprouting tolerance. It ranged from 0-5.8% among the genotypes. High estimates of genotypic (GCV) and phenotypic coefficients of variation (PCV) were recorded for the percentage of pods ruptured by sprouting seed (PPR) indicating the presence of wider variability over which selection can be effective. High heritability coupled with high genetic advance as percent mean was recorded for number of pods ruptured by sprouting seed per plant and PPR. The phenotypic character association revealed a significant negative correlation of PPR with pod wall thickness, number of pods per plant, and number of clusters per plant. Path coefficient analysis revealed number of pods per plant, plant height, and pod wall thickness have a negative influence on pre-harvest sprouting.
    Type of Medium: Online Resource
    ISSN: 2457-1024
    URL: Article
    DOI: 10.9734/cjast/2021/v40i431290
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Evaluation of Antioxidant and Anti-Inflammatory Activity of Methanolic Extract of Rhus chinensis Seed: In-vitro Studies
    Sciencedomain International ; 2022
    In:  Asian Journal of Research in Biochemistry ( 2022-07-25), p. 32-41
    Details
    In: Asian Journal of Research in Biochemistry, Sciencedomain International, ( 2022-07-25), p. 32-41
    Abstract: Rhus chinensis is a dioecious shrub, found in warm temperate zone across Asia. In India it is found in Northeastern part like South Assam, Arunachal Pradesh, West Bengal and Tamil Nadu. [16] The roots, stem, leaves and seed have various therapeutic effects on ailments like hemoptysis, jaundice, snakebites, diabetes. Phytochemical analysis of Rhus chinensis extracts revealed the presence of various biochemical compounds such as alkaloids, flavonoids, tannins, triterpenoids, amino acids, proteins and carbohydrates. These compounds have well proven remarkable anti-oxidant and anti-inflammatory activity. The adverse effect of oxidative stress results in many disorders such as aging, cardiovascular disorders and so on. Inflammation is yet again another problem which causes many disorders like rheumatoid arthritis, asthma and Crohn’s disease etc. This research was conducted to evaluate the antioxidant and anti-inflammatory effect of Rhus chinensis seed (Methanolic Extract). The in-vitro antioxidant activity was carried out by testing 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and ferric chloride reducing activity. Further, effect on protein denaturation, inhibition of proteinase and Human Red Blood Cell (HRBC) membrane stabilization was carried out to screen for anti-inflammatory activity.The total phenolic content was found to be 5 mg/mL of Gallic acid equivalent (GAE) and flavonoid content was found to be 335 µg/mL of Quercetin equivalent (QE). Aspirin and Diclofenac sodium were used as standard drug. All the assays showed positive results and it was concentration dependent. Thus, Rhus chinensis seed is a promising anti-oxidant and anti-inflammatory agent with significant activity. Moreover, the use of natural products like Rhus chinensis can be highly efficient, beneficial, cost effective, safer alternative with lesser side effects. Altogether, studies on Rhus chinensis seeds have huge scope as an alternative ethno-pharmaceutical compound for inflammations.
    Type of Medium: Online Resource
    ISSN: 2582-0516
    URL: Article
    DOI: 10.9734/ajrb/2022/v10i330226
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2022
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  • 3
    Online Resource
    Online Resource
    The Pharmaceutical Application of Sulfoxy Amine Chitosan in Design, Development and Evaluation of Transdermal Drug Delivery of Gliclazide
    Sciencedomain International ; 2020
    In:  Journal of Pharmaceutical Research International ( 2020-08-28), p. 145-161
    Details
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2020-08-28), p. 145-161
    Abstract: Objective: The aim & objectives of this research work was to explore applicability of our previously synthesized sulfoxy amine chitosan in design, development and evaluation of transdermal drug delivery of Gliclazide. Methods: To determine the interaction between excipients used and to find out the nature of drug in the formulation, Fourier transforms infra-red spectroscopy (FTIR) and Differential Scanning Colorimetry (DSC) studies were performed. Gliclazide containing transdermal patch were formulated with help of Sulfoxy Amine Chitosan, HPMC, Penetration enhancer Dimethyl Sulfoxide and Glycerine by using solvent casting method.9 formulations prepared by using 32 full factorial designs the effect of formulation variable was studied on % Moisture Content, Folding endurance, % Cumulative drug release at 12 hrs.Formulated transdermal patches were evaluated for various parameters. Results: FTIR & DSC suggest study no drug & polymers interaction .All the prepared transdermal patches were found to be faint yellow in colored, flexible, uniform, smooth, and transparent. The weight of the transdermal patches for different type of formulations ranged between 12.00 ± 0.6 mg & 14.2 ± 0.52 mg. The thickness of the patches varied from 0.171 ± 0.0035 mm to 0.182 ± 0.0026 mm. The moisture content & water vapour transmission rate in the patches ranged from 2.33 to 4.55% & from 0.002246 to 0.003597 mg.cm/cm2 24hrs.XRD diffractogram revealed  pure Gliclazide exhibited characteristic high-intensity diffraction peaks & optimized formulation showed  three peaks in 2θ= 20.6 28.7 and 38.95 with very weak intensities. Optimized batch F7 showed maximum drug release 98.41%. The folding endurance was lies in between 301 and 359. Optimization study was successfully conducted using 32 factorial designs. Conclusion: We concluded that transdermal patches Gliclazide of was successfully formulated with synthesized Sulfoxy Amine Chitosan & evaluated.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    URL: Article
    DOI: 10.9734/jpri/2020/v32i2030738
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2020
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  • 4
    Online Resource
    Online Resource
    Methods for the Detection and Quantification of Micro and Nanoplastics- A Review
    Sciencedomain International ; 2021
    In:  Asian Journal of Biotechnology and Bioresource Technology ( 2021-10-09), p. 39-51
    Details
    In: Asian Journal of Biotechnology and Bioresource Technology, Sciencedomain International, ( 2021-10-09), p. 39-51
    Abstract: Over the past 35 years, synthetic or semi-synthetic polymers called “plastics” have been widely used across multiple fields due to their low cost, versatility, durability. Plastics have proved to be a boon to mankind. However, overuse of non- biodegradable plastics comes with its own downsides. Despite constant efforts to reuse and recycle plastics, these polymers substantially contribute towards the accumulation of debris hazardous to the environment. Plastic materials are slowly broken into fragments of micro- and nano plastics due to aging and weathering. Micro- and nano plastics were found capable of entering the food chain and hence are viewed as threats. This review paper revolves around methods used for the detection and quantification of micro- and nano plastics. Detection of micro- and nano plastics using methods like Raman spectroscopy, Infrared Spectroscopy, SERS, MALDI-TOF, and machine learning approaches are discussed here. The research efforts carried out in this article aims to further facilitate the R & D initiatives of Jozbiz Technologies.
    Type of Medium: Online Resource
    ISSN: 2457-0125
    URL: Article
    DOI: 10.9734/ajb2t/2021/v7i430108
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Bioanalytical Method Development and Validation for the Determination of Favipiravir in Spiked Human Plasma by using RP-HPLC
    Sciencedomain International ; 2021
    In:  Journal of Pharmaceutical Research International ( 2021-10-26), p. 275-281
    Details
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-10-26), p. 275-281
    Abstract: A precise, simple and reproducible reverse phase liquid chromatography (RP-HPLC) method was developed and validated for determination of Favipiravir by using Carbamazepine as internal standard in spiked human plasma. A chromatographic separation was accomplished with Cromasil C18 (250mm x 4.6ID, Particle size: 5 micron) column using mobile phase consists of methanol: water in the ratio (35:65, %v/v), at pH 3.0 with binary gradient system-maintained flow rate at 0.8ml/min. The detection wavelength of drug sample was at 225 nm. Extraction was done by using ethyl acetate as extracting solvent. The retention time of Favipiravir was found to be 6.62 min.  The method was found to be linear in the concentration range of 0.2-3.2 µg/ml. Limit of quantitation (LOQ) value was found to be 0.72. The intra- and inter day precision and accuracy lies within the specified range. The recovery studies were found to be in the range of 97.6 to 100.2%. %Relative standard deviation (RSD) was found to be in the range of 0.07-2.80%. All parameters were found to be validated from spiked human plasma. The proposed RP-HPLC method is highly accurate and rapid for the determination of favipiravir in human plasma and can be applied for pharmacokinetic studies and Therapeutic drug monitoring.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    URL: Article
    DOI: 10.9734/jpri/2021/v33i47A33014
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    The Gag Reflex: A Hurdle in Dentistry– Literature Review
    Sciencedomain International ; 2021
    In:  Journal of Pharmaceutical Research International ( 2021-10-21), p. 224-237
    Details
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-10-21), p. 224-237
    Abstract: Gagging reflex poses a hurdle in numerous dental procedures. It causes discomfort for the patient, extended procedure time for the clinician, compromised quality of treatment and along with a lot of physiological discomfort for both. The normal gag reflex is protective in nature, but few individuals elicit extreme response, leading to problems during the treatment procedures. It is extremely important for the clinician to identify the cause and severity of the condition so that it can be decided whether the patient can handle standard treatment techniques or whether alternative methods must be considered. There is no universal solution for successfully managing the gagging patient. Various modalities can be used according to the doctor’s assessment and patient’s conditions in order to control the gag reflex so that the patient can be comfortable and cope with the dental treatment. A wide range of management solutions are available, and many cases need a combination of therapeutic procedures. The main aim of the present article is to comprehensively report the clinical significance, etiology, symptoms and various management approaches used during prosthodontic treatments.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    URL: Article
    DOI: 10.9734/jpri/2021/v33i46B32937
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Assessing Salivary Flow Rate, Salivary pH and Oral Candidiasis among Tobacco Chewers, Smokers and Healthy Controls- A Cross Sectional Study
    Sciencedomain International ; 2017
    In:  Asian Journal of Medicine and Health Vol. 7, No. 4 ( 2017-01-10), p. 1-8
    Details
    In: Asian Journal of Medicine and Health, Sciencedomain International, Vol. 7, No. 4 ( 2017-01-10), p. 1-8
    Type of Medium: Online Resource
    ISSN: 2456-8414
    URL: Journal
    URL: Article
    DOI: 10.9734/AJMAH
    DOI: 10.9734/AJMAH/2017/36522
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2017
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