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  • 1
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-12-23), p. 1392-1399
    Abstract: Antiphospholipid syndrome is defined as the presence of antiphospholipid antibodies in the setting of thrombosis and/or pregnancy loss (APLS).Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory condition that affects individuals and their families in a negative and often fatal way. There are the two types of APS: Primary APS, which develops on its own, and secondary APS, which is linked to another autoimmune disorder, most often systemic lupus erythematosus (SLE). The HLA-DR7, DR4, DRw53, DQw7, and C4 null alleles have all been linked to APLS. APS is frequently misdiagnosed due to clinical diversity and a lack of diagnostic test consistency. The classification criteria were created to categorise APS patients for research reasons, but they can also be used by professionals to establish diagnoses. Unprovoked thrombosis is currently treated with long-term warfarin or another vitamin K antagonist drug. To avoid obstetric complications, low-dose aspirin and prophylactic heparin, primarily low-molecular-weight heparin, are utilised.In this article we’ll be looking at Anti-phospholipid Syndrome, it’s etiology, epidemiology, evaluation and management.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 2
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-12-18), p. 759-765
    Abstract: Evidence indicates that Maturity-onset diabetes of the young (MODY) exhibits an autosomal dominant inheritance and is the most common type of monogenic diabetes. However, it should be noted that misdiagnosis of the condition is very common, as patients are usually mistaken for both types I and type II diabetes mellitus. In the present study, we have discussed the etiology, pathogenesis, and epidemiology of MODY based on an extensive literature review. Genetic mutations are mainly attributed to the development of the disease, which usually manifests throughout the second to fifth decades of life. Pancreatic islet cell destruction, impaired insulin secretion, defects regarding threshold to serum glucose levels, and other pathological events are usually observed in these patients. Data regarding the epidemiology of the condition is not adequately reported in the literature, especially among non-European populations, indicating the need to conduct future investigations. Ethnic and age variations are potentially epidemiological characteristics of the disease. However, not enough data are present in the literature to support such conclusions.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Sciencedomain International ; 2021
    In:  Journal of Advances in Medicine and Medical Research ( 2021-12-25), p. 214-226
    In: Journal of Advances in Medicine and Medical Research, Sciencedomain International, ( 2021-12-25), p. 214-226
    Abstract: Background: Adult scoliosis is a common spine deformity. It is very debilitating to daily activities of the patients. Surgical management requires a clear assessment of the functional impact of scoliosis, the failure of conservative treatments and precise analysis of radiological investigations (full spine views, dynamic X-rays and MRI). The back pain was the main complaint as it was the main presentation. The aim of the work is to assess the outcomes of surgical procedures in patients with adult scoliosis. Methods: This prospective study was conducted on 30 patients with adult scoliosis with cobb angel more than 10 degrees. Surgical techniques (anterior and posterior approaches, decompression, osteotomies, fusion, and instrumentation) done and tailored to each patient. Decompression alone found usually not enough, fusion needed almost in all cases. Results: Patient disability using Oswestry disability index assessed before and after intervention.  Also a good, accepted change achieved as 15 patients restore about 75% of their abilities ,7 patients restore more than 50% of their usual ability,3 patients restore about 25% of their usual ability. Cobb’s angel before intervention was 6 cases 〈 60 degrees,14 cases between 50 and 60 degrees and 10 cases between 40 and 50 degrees became 14 cases between 10 and 0 degrees, and 10 cases between 10 and 20 degrees. Surgical treatment of adult scoliosis is associated with a better quality of life for patients when good selection of the patient and maneuvers done. Visual analogue scale before and postoperative, and three and six months later detect ,a good result achieved, As VAS before intervention was ; 20 patients from 9 to 10,9 patients from 6 to 8, one patient from 3 to 5. VAS post-operative after sex months became only four patients from 6 to 8, twenty four patients from 3 to 5and only two patients from 0 to 2. Conclusions: Surgical management of adult scoliosis become more applicable, Spine managed as one unit, Correction of coronal and sagittal malalignment done together, Do not neglect one of them. Using both free hand , c arm and even navigator when needed help in good outcomes and complications avoidance, management strategy differ according many factors, The technique requires proper selection of cases before surgery and meticulous attention during surgery to identify the correct starting point, screw orientation and screw length selection. Surgical outcomes of adult scoliosis clinical, radiological and neurological outcome were satisfied without major complications.
    Type of Medium: Online Resource
    ISSN: 2456-8899
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
    detail.hit.zdb_id: 3166828-8
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  • 4
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-12-17), p. 8-16
    Abstract: Spinal cord injury is a serious medical disorder that frequently leads in significant morbidity and permanent impairment. Direct damage to the spinal cord or compression owing to broken vertebrae or masses such as epidural hematomas or abscesses are the most common causes of spinal cord injury. When examining a blunt trauma victim, medical professionals are taught to presume the patient has a spinal column damage unless it is proven otherwise. The early examination of a patient with a suspected cervical spinal injury in the emergency department (ED) is no different than that of any other trauma patient. The ABCs, or airway, breathing, and circulation, procedures are being taken into consideration. In acute spinal cord damage, hypotension can be hemorrhagic or neurogenic. Because of the high prevalence of concomitant injuries and vital sign confusion in acute spinal cord injury, a thorough search for hidden sources of bleeding is required. Surgical removal of bone fragments, foreign objects, herniated discs, or broken vertebrae that appear to be compressing the spine is frequently required. In order to avoid future discomfort or deformity, surgery may be required to stabilize the spine. In this review we’ll be looking at spinal cord injury, it’s diagnosis and treatment.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 5
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-11-11), p. 45-54
    Abstract: The Dental amalgam used in the dental fillings is basically an alloy of mercury (Hg). The amalgam is one of the most commonly used and versatile restorative material. Since more than 150 years this alloy of mercury, that is amalgam is used for it been economical, easy to use, durable, high strength and bacterio-static characteristics. Due to environmental pollution, detrimental health its use is decreasing in recent times. Also its not so appealing like the other materials used that resemble the tooth color. The tooth coloured restorative materials are recommended by both the doctor and the patient. Many researchers suggested that over the period of time the mercury from the filling might leach into the mouth. Thus in this study a detailed review of all the literature available online is done to understand the hazardous effects of dental amalgam fillings in the human body. The systematic literature search using Scopus, PubMed, EMBASE and Web of Science electronic databases was done using PRISMA. The experiments conducted in Sheep and monkey suggested the penetration of amalgam into the jaw bone of the patient with dental restorations. Constant exposure of mercury at lower levels can also lead to multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Most commonly reported renal dysfunction due to the dental amalgams are Tubular and Glomerular damage of the kidneys.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Sciencedomain International ; 2023
    In:  Journal of Advances in Medicine and Medical Research Vol. 35, No. 16 ( 2023-06-20), p. 1-13
    In: Journal of Advances in Medicine and Medical Research, Sciencedomain International, Vol. 35, No. 16 ( 2023-06-20), p. 1-13
    Abstract: Background: Thrombosis is a major disorder with serious complications. The JAK2V617F mutation results in constitutive phosphorylation of JAK2 and activation of the cellular proliferation cascade. The present study aimed to clarify the prevalence of JAK2V617F mutation in patients with thrombosis. Subjects and Methods: This case-control study was conducted on 60 subjects subdivided into 2 groups: 30 healthy subjects as a control group (Group I) and 30 patients diagnosed with thrombosis (Group II). All subjects were subjected to full history taking, and clinical examination and investigated for Molecular detection of JAK2V617F mutation, FV (Factor V Leiden) – PTH (Prothrombin), and MTHFR (Methylene tetrahydro-folate reductase). Results: There was a statistically significant difference among the studied groups as regards the JAK2V617F mutation (P value 〈 0.05, odds ratio = 41.216, 95% C.I. 95% = 2.302 - 738.034, relative risk = 25, 95% C.I. 95% = 1.547– 404.012). This mutation was more significantly associated with venous thrombosis than arterial thrombosis (P = 〈 0.05). Conclusion: This study showed a significant association between JAK2V617F mutation and thrombosis with more significant evidence in the venous than the arterial thrombosis.
    Type of Medium: Online Resource
    ISSN: 2456-8899
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2023
    detail.hit.zdb_id: 3166828-8
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  • 7
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-12-15), p. 419-425
    Abstract: Any infectious illness of the upper or lower respiratory tract is classified as a respiratory tract infection (RTI). Acute bronchitis, bronchiolitis, pneumonia, and tracheitis are examples of lower respiratory tract infections (LRTIs). The most prevalent cause of death from lower respiratory infections is pneumococcal pneumonia. Pneumonia is a major cause of death globally. new advances in pneumonia diagnosis and treatment have been made, identification of new pathogens as well as the development of newer therapeutic agents like fluoroquinolones, macrolides, streptogramins, oxazolidinones, and –actam antibiotics. Despite these advancements, respiratory tract infections continue to be a challenge in both the diagnostic and therapeutic domains. Because detecting and treating pneumonia may be difficult, a number of professional organizations have created treatment recommendations. In this review we’ll be looking at LRTIs and pneumonia epidemiology, etiology, diagnosis and treatment.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    Sciencedomain International ; 2021
    In:  Journal of Pharmaceutical Research International ( 2021-07-31), p. 98-102
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-07-31), p. 98-102
    Abstract: Aim: To find out the prevalence of color blindness among medical students. Study Design: Descriptive cross-sectional. Place and Duration of Study: Study was conducted at Chaudry Mohammad Akram teaching and research hospital, Superior university during December 2020 to May 2021. Methodology: All the medical students having age range between 21-25 years were included in the study. An ophthalmologist did ocular examination, after that color vision was checked by putting Ishihara plates. The score less than 12 out of 14 red-green test plates were labelled as color blind. Data was analyzed by using the SPSS version 20. Chi-square was used to find out the association of color blindness with age groups and gender. p-value less than 0.05 was considered as significant. Results: The mean age with standard deviation of study participants was 23.27 ± 0.87 years. The prevalence of color blindness among medical students was 2% out of which 1.7% were having strong red-green deficiency while only 0.3% were with mild red-green deficiency. Majority of participants with color blindness were noted in the age group of 22 years while very few were in the other age groups of medical students but these results were non-significant. On the other hand, all the color blind was male but no association was found as the p-value was more than 0.05. Conclusion: Current study reported that about 2% of medical students are affected by color vision deficiency. So there is a need of proper visual screening program among medical undergraduates for early detection of color blindness and counselling session for them.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 9
    Online Resource
    Online Resource
    Sciencedomain International ; 2020
    In:  Journal of Advances in Medicine and Medical Research ( 2020-03-26), p. 10-15
    In: Journal of Advances in Medicine and Medical Research, Sciencedomain International, ( 2020-03-26), p. 10-15
    Abstract: Background: In the 1970’s the introduction of Fine Need Aspiration Cytology (FNAC) proved to be the key method for examining the nature and malignant potential of many palpable lesions like thyroid, salivary glands and lymphadenopathies. Breast pathologies is one of the entity that can also be diagnosed with FNAC. Breast cancer is the most common malignancy of women with overall 100,000 cases being reported annually around the globe. The most frequent lesion encountered using FNAC in breast is fibro-adenoma followed by fibrocystic disease, breast abscess, chronic inflammatory conditions and suspicious malignant masses. In current cross sectional study we tried to find frequency of different breast lesions by FNAC. Methodology and Results: 649 samples were recruited from the Vital Laboratory Larkana with different pathological lesions of breast during the year 2014 and 2015 by non-probability consecutive sampling. 613 (95%) were females and 32 (5%) were male with mean age of 30.8±12.8 years. Majority of case were of 20-39 years of age (55.8%). Most of the cases were diagnosed with benign lesions (329, 51%) followed by inflammatory lesions (132, 20.5%) and gynecomastia (15, 2.3%). Right breast was more affected (329, 51%). In present study we found a strong association of diagnosis with gender (p =0.000) and age (p =0.000). Conclusion: So in this study it is concluded that large number of females with breast pathologies present with benign lesions like fibro-adenoma at the age of 20-39 years. It is also concluded that in this age group mastitis and abscesses are common due to different risk factors.
    Type of Medium: Online Resource
    ISSN: 2456-8899
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2020
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  • 10
    Online Resource
    Online Resource
    Sciencedomain International ; 2020
    In:  South Asian Journal of Research in Microbiology ( 2020-04-24), p. 1-9
    In: South Asian Journal of Research in Microbiology, Sciencedomain International, ( 2020-04-24), p. 1-9
    Abstract: The fermented solution of this strain contains the highest concentration of citric acid, indole acetic acid (IAA) and elements as well as phosphatase activity. Using the Aspergillus tubingensis USMI03 RPf10 fermented solution as a medium led to decrease in the growth rate of tested bacterial isolates (Bacillus subtilis, Pseudomonas fluorescens and Escherichia coli) and fungal isolates (Aspergillus sp. and Penicillium sp.) except Trichoderma viride which gave the same growth on fermented solution treatments compared to control. Whereas the tested yeast isolates (Candida olivera and Saccharomyces cerevisiae) recorded the same growth rate on fermented solution treatments as whole media and higher growth rate on fermented solution + glucose treatment, compared to control. Also, the latter treatment resulting in higher growth of some tested bacteria (B. subtilis and P. fluorescens) and the same growth rate of other bacteria (E. coli), compared to synthetic media. The growth of Rhizopus sp. decreased on fermented solution treatments than control. It is suggested that, using A. tubingensis USMI03 RPf10 fermented solution as a whole medium or as a mineral could be used as a source for microbial growth which varied from one microorganism to another.
    Type of Medium: Online Resource
    ISSN: 2582-1989
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2020
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