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  • Sciencedomain International  (2)
  • 1
    Online Resource
    Online Resource
    Effect of Guiera senegalensis and Natron on Serum Indices of Cardiac Function of Postpartum Rats
    Sciencedomain International ; 2021
    In:  Journal of Advances in Biology & Biotechnology ( 2021-09-25), p. 32-46
    Details
    In: Journal of Advances in Biology & Biotechnology, Sciencedomain International, ( 2021-09-25), p. 32-46
    Abstract: Peripartum cardiomyopathy (PPCM) is a rare but devastating cardiac failure of indeterminate etiology occurring in late pregnancy or early puerperium. The prevalence of PPCM in Northern Nigeria could be attributed to the unique customary puerperal practices of prolonged consumption oflarge quantities of Guiera senegalensis and Natron. This study investigated the effect of decoction of G. senegalensis with and without Natron on cardiac markers, lipid profile and histology ofheart in postpartum female albino rats using standard methods.Thirty-five (35)female albino rats of body weights 190-200 g of five month were randomly grouped into seven (7) of five rats each. Group 2, 3 and 4 were orally administered with 100, 200 and 300 mg/kg body weight of G. senegalensis. Group 5, 6 and 7 were orally administered with 100, 200 and 300 mg/kg body weight (1:1) of G. senegalensis and Natron by gavage, whereas group 1 received distilled water. The study revealed significant (p 〈 0.05) decrease in triglyceride(TG) in group 2 to VII, high density lipoproteincholesterol (HDL-c) in group 2, 5 and 6, very low density lipoprotein- cholesterol (VLDL-c) in group 3 to V, couples with significant (p 〈 0.05) increase in low density lipoprotein cholesterol (LDL-c) in group 2, 3, 5 and 7, and for (AIX) in group 2, total cholesterol(TC) in group 2, 3 and 7 when compared with control. Significant (p 〈 0.05) increase in Lactate dehydrogenase (LDH) in group 3 to 7, and Myoglobin (MB) in group 3 was observed. Significant (p 〈 0.05) decrease in Troponin I (TnI) in group 2 and 4 was seen. There were no significant (p 〉 0.05) changes in Troponin T (Tn T), aspartate amino transferase (AST) and Creatine Kinase(CK-NAC) of the treatment group when compared to control group. Histopathological examination of section of the heart revealed ventricular dilatation, hypertrophied with enlarged nuclei, stretched, and irregular and mural thrombi in group 2 to 4 and 7. Inflammation in group 5 and 7, Pigment deposited in group 4 to 7 and Mild fibrosis in group 3 were observed. The study demonstrates that consumption of G. senegalensis and Natron for 28 days’induces dyslipidemia and causes changes in the heart of postpartum rats and thus may contribute to the pathogenesis of PPCM.
    Type of Medium: Online Resource
    ISSN: 2394-1081
    URL: Article
    DOI: 10.9734/jabb/2021/v24i730226
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Evaluation of Different Aphrodisiac Therapy Effect by Using Some Biochemical Parameters in Female Wistar Albino Rats
    Sciencedomain International ; 2023
    In:  International Journal of Biochemistry Research & Review Vol. 32, No. 3 ( 2023-06-07), p. 1-9
    Details
    In: International Journal of Biochemistry Research & Review, Sciencedomain International, Vol. 32, No. 3 ( 2023-06-07), p. 1-9
    Abstract: Since ancient times, humans across diverse tradition, cultures and religious background have shown keen interest in traditional herbal products which enhance sexual ability, pleasure and libido as well as improving sexual functions and potency. The use of herbal aphrodisiacs among men and women in Nigeria is on the high side.  This research aimed to study the effect of Mi jian fen (MJF) (a foreign aphrodisiac) and Tsumin marke (TM) (a local aphrodisiac) on female libido. The research also aimed at determining the possible effects of MJF and TM on some toxicological parameters. Eighteen Female wistar albino rats were selected randomly and assigned into six groups of three animals each. Group A served as the control group. Group B served as the standard rats in this group were given 0.2mg/kg dose of Clomid. Groups C and D were given low (0.2mg/kg) and high (0.4mg/kg) doses of MJF respectively. Groups E and F were given low (0.2mg/kg) and high (0.4mg/kg) doses of TM, respectively. All treatments were administered for a period of thirty days after which rats were sacrificed and blood samples collected. FSH, LH, Estrogen, ALT, AST, ALP, Urea, Creatinine and Hematological parameters were assayed using standard methods. At the end of the analysis, it was observed that the levels of LH increased significantly (p 〈 0.05) in all the groups that were treated with high and low doses of MJF and TM, likewise FSH and estrogen. AST and ALT were slightly increased in all test groups while ALP was increased significantly (p 〈 0.05) in all test groups. Urea increased significantly (p 〈 0.05) in all test groups while creatinine increased slightly in all test groups. The results obtained confirmed MJF and TM to be potent aphrodisiacs. However, MJF shows to be a bit more libido enhancer them TM. The toxicity of MJF on the liver and kidney of the animals seem to be higher compared to that of TM. It is then concluded that long term usage of these substances could lead to clinical complications among human users.
    Type of Medium: Online Resource
    ISSN: 2231-086X
    URL: Article
    DOI: 10.9734/ijbcrr/2023/v32i3802
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2023
    detail.hit.zdb_id: 2617241-0
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