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  • 1
    Electronic Resource
    Electronic Resource
    FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy (2000)
    Springer
    European journal of nuclear medicine 27 (2000), S. 1305-1311 
    Details
    ISSN: 1619-7089
    Keywords: Fluorine-18 fluorodeoxyglucose Positron emission tomography Bone scintigraphy Malignant primary bone tumours Osseous metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to compare positron emission tomography using fluorine-18 fluorodeoxyglucose (FDG-PET) and technetium-99m methylene diphosphonate (MDP) bone scintigraphy in the detection of osseous metastases from malignant primary osseous tumours. In 70 patients with histologically proven malignant primary bone tumours (32 osteosarcomas, 38 Ewing's sarcomas), 118 FDG-PET examinations were evaluated. FDG-PET scans were analysed with regard to osseous metastases in comparison with bone scintigraphy. The reference methods for both imaging modalities were histopathological analysis, morphological imaging [additional conventional radiography, computed tomography (CT) or magnetic resonance imaging (MRI)] and/or clinical follow-up over 6–64 months (median 20 months). In 21 examinations (18%) reference methods revealed 54 osseous metastases (49 from Ewing's sarcomas, five from osteosarcomas). FDG-PET had a sensitivity of 0.90, a specificity of 0.96 and an accuracy of 0.95 on an examination-based analysis. Comparable values for bone scintigraphy were 0.71, 0.92 and 0.88. On a lesion-based analysis the sensitivity of FDG-PET and bone scintigraphy was 0.80 and 0.72, respectively. Analysing only Ewing's sarcoma patients, the sensitivity, specificity and accuracy of FDG-PET and bone scan were 1.00, 0.96 and 0.97 and 0.68, 0.87 and 0.82, respectively (examination-based analysis). None of the five osseous metastases from osteosarcoma were detected by FDG-PET, but all of them were true-positive using bone scintigraphy. In conclusion, the sensitivity, specificity and accuracy of FDG-PET in the detection of osseous metastases from Ewing's sarcomas are superior to those of bone scintigraphy. However, in the detection of osseous metastases from osteosarcoma, FDG-PET seems to be less sensitive than bone scintigraphy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590000301
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Leben am Meeresboden (2017)
    SPRINGER
    In:  EPIC3Faszination Meeresforschung, Faszination Meeresforschung, Heidelberg, SPRINGER, pp. 179-210, ISBN: 978-3-662-49714-5
    Details
    Publication Date: 2017-01-18
    Repository Name: EPIC Alfred Wegener Institut
    Type: Inbook , peerRev
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    PAPER (OA)
  • 3
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    Spatial distribution patterns of ascidians (Ascidiacea: Tunicata) on the continental shelves off the northern Antarctic Peninsula. (2016)
    SPRINGER
    In:  EPIC3Polar Biology, SPRINGER, 39(5), pp. 863-879, ISSN: 0722-4060
    Details
    Publication Date: 2017-01-20
    Description: Ascidians (Ascidiacea: Tunicata) are sessile suspension feeders that represent dominant epifaunal components of the Southern Ocean shelf benthos and play a significant role in the pelagic–benthic coupling. Here, we report the results of a first study on the relationship between the distribution patterns of eight common and/or abundant (putative) ascidian species, and environmental drivers in the waters off the northern Antarctic Peninsula. During RV Polarstern cruise XXIX/3 (PS81) in January–March 2013, we used seabed imaging surveys along 28 photographic transects of 2 km length each at water depths from 70 to 770 m in three regions (northwestern Weddell Sea, southern Bransfield Strait and southern Drake Passage), differing in their general environmental setting, primarily oceanographic characteristics and sea-ice dynamics, to comparatively analyze the spatial patterns in the abundance of the selected ascidians, reliably to be identified in the photographs, at three nested spatial scales. At a regional (100-km) scale, the ascidian assemblages of the Weddell Sea differed significantly from those of the other two regions, whereas at an intermediate 10-km scale no such differences were detected among habitat types (bank, upper slope, slope, deep/canyon) on the shelf and at the shelf break within each region. These spatial patterns were superimposed by a marked small-scale (10-m) patchiness of ascidian distribution within the 2-km-long transects. Among the environmental variables considered in our study, a combination of water-mass characteristics, sea-ice dynamics (approximated by 5-year averages in sea-ice cover in the region of or surrounding the photographic stations), as well as the seabed ruggedness, was identified as explaining best the distribution patterns of the ascidians.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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    PAPER (OA)
  • 4
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    Spring-to-summer changes and regional variability of benthic processes in the western Canadian Arctic (2011)
    Springer
    In:  EPIC3Polar Biology, Springer, 34(12), pp. 2025-2038, ISSN: 0722-4060
    Details
    Publication Date: 2016-03-13
    Description: Seasonal dynamics in the activity of Arctic shelf benthos have been the subject of few local studies, and the pronounced among-site variability characterizing their results makes it difficult to upscale and generalize their conclusions. In a regional study encompassing five sites at 100–595 m water depth in the southeastern Beau- fort Sea, we found that total pigment concentrations in surficial sediments, used as proxies of general food supply to the benthos, rose significantly after the transition from ice-covered conditions in spring (March–June 2008) to open-water conditions in summer (June–August 2008), whereas sediment Chl a concentrations, typical markers of fresh food input, did not. Macrobenthic biomass (including agglutinated foraminifera [500 lm) varied significantly among sites (1.2–6.4 g C m-2 in spring, 1.1–12.6 g C m-2 in summer), whereas a general spring-to-summer increase was not detected. Benthic carbon remineralisation also ranged significantly among sites (11.9–33.2 mg C m-2 day-1 in spring, 11.6–44.4 mg C m-2 day-1 in summer) and did in addition exhibit a general significant increase from spring-to-summer. Multiple regression analysis suggests that in both spring and summer, sediment Chl a concentration is the prime determinant of benthic carbon remineralisation, but other factors have a significant secondary influence, such as foraminiferan biomass (negative in both seasons), water depth (in spring) and infaunal biomass (in summer). Our findings indicate the importance of the combined and dynamic effects of food supply and benthic community patterns on the carbon remineralisation of the polar shelf benthos in seasonally ice-covered seas.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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    PAPER (OA)
  • 5
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    Unknown
    Leben am Meeresboden (2017)
    Springer
    In:  In: Faszination Meeresforschung : ein ökologisches Lesebuch. , ed. by Hempel, G., Bischof, K. and Hagen, W. Springer, Heidelberg, Germany, pp. 179-210. 2. Aufl. ISBN 978-3-662-49713-5
    Details
    Publication Date: 2020-04-03
    Type: Book chapter , NonPeerReviewed
    Format: text
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    OceanRep: Book chapter
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